A5101917990- Heat shock proteins research
- Protein Structure and Dynamics
- Mosquito-borne diseases and control
- Enzyme Structure and Function
- Magnetism in coordination complexes
- Metal complexes synthesis and properties
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- Medicinal Plant Pharmacodynamics Research
- Metal-Organic Frameworks: Synthesis and Applications
- Cytokine Signaling Pathways and Interactions
- Hemoglobin structure and function
- Cancer-related Molecular Pathways
- Bone health and treatments
- Cancer Cells and Metastasis
- Viral Infections and Vectors
- Malaria Research and Control
- Crystal structures of chemical compounds
- Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Advanced Cellulose Research Studies
- Management of metastatic bone disease
- Biofuel production and bioconversion
- Colorectal Cancer Treatments and Studies
- Virology and Viral Diseases
First Hospital of Shanxi Medical University
2025
Shanxi Medical University
2021-2025
Xi'an Medical University
2021-2023
Ningxia Medical University
2023
First Affiliated Hospital of Fujian Medical University
2021
Fujian Medical University
2021
Chengde Medical University
2021
Hebei Agricultural University
2015
Background: Shaoyao-Gancao Decoction (SG-D) is a famous classical Chinese prescription that has been used in the treatment of numerous kinds diseases. However, its mechanism action Gastric carcinoma (GC) not clear. Methods: The active ingredients and targets SG-D were screened using network pharmacology, GC-related retrieved through several databases. protein-protein interaction was then further constructed GO KEGG enrichment analysis performed. Subsequently, molecular docking carried out....
Abstract Background The role of surgery for the primary tumor in breast cancer patients with bone metastases (BM) remains unclear. purpose this study was to determine impact BM and develop prognostic nomograms predict overall survival (OS) BM. Methods A total 3956 from Surveillance, Epidemiology, End Results database between 2010 2016 were included. Propensity score matching (PSM) used eliminate bias non-surgery groups. Kaplan-Meier analysis log-rank test performed compare OS two Cox...
New targeted chemotherapy agents greatly improved five-year survival in NSCLC patients, but which were susceptible to drug resistance. NVP-AUY922, terminated phase II clinical trials, exhibited promising anti-NSCLC (non-small-cell lung cancer) activity targeting Hsp90N (heat shock protein), demonstrated advantages overcoming resistance as a broad-spectrum anti-cancer target. It was expected develop novel drugs overcome by the structural optimization of NVP-AUY922. However, absence...
GRWD1 (glutamate-rich WD40 repeat containing 1) is a multifunctional protein involved in multiple cellular regulatory pathways, particularly those associated with cell growth control. represented as potential oncogene several cancers, however, the function and mechanism of development colon cancer are still unknown.IHC was used to detect expression carcinoma tissues. CCK-8, colony formation, EdU were measure proliferation after knockdown overexpression. The distribution cycle analyzed by...
The Ilheus virus (ILHV) is an encephalitis associated arthropod-borne flavivirus. It was first identified in City the northeast Brazil before spreading to a wider geographic range. No specific vaccines or drugs are currently available for treatment of ILHV infections. helicase, like other flavivirus helicases, possesses 5'-triphosphatase activity. This allows it perform ATP hydrolysis generate energy as well sustain double-stranded RNA's unwinding during genome replication. Thus, helicase...
The reaction of 2-acetylpyridine, cyclopentylamine, and copper(II) bromide in methanol resulted the tetranuclear complex [Cu4L2(μ-Br)2Br2], where L is dianionic form 1-methoxy-1,3-dipyridin-2-ylpentane-1,3-diol. was characterized by elemental analysis IR spectroscopic method solid state. Single-crystal X-ray performed, which indicated that possesses crystallographic twofold rotation axis symmetry. crystallizes tetragonal space group P43212 with unit cell dimensions a = b 8.963(1) Å, c...
The reaction of 2-acetylpyridine, cyclohexylamine and copper(II) perchlorate in methanol resulted the dinuclear complex [Cu2L2]·2ClO4, where L is monoanionic form 1-methoxy-1,3-dipyridin-2-ylbutane-1,3-diol. was characterized by elemental analysis IR spectroscopic method solid state. Single-crystal X-ray performed, which indicated that possesses a crystallographic inversion center symmetry. Cu atom square pyramidal geometry. Thermal behavior biological property on bacteria strains B....
Ethnopharmacological relevance: The incidence of gastric carcinoma (GC) is increasing rapidly. Traditional Chinese medicine (TCM) plays a unique role in the treatment GC. At present, Gancao Xiexin decoction (GCXXD) has been proved to have good therapeutic effect on diseases spleen and stomach system, but relevant molecular mechanisms remain incompletely explained.Aim study: mechanism GCXXD for GC was investigated by network pharmacology verified cell experiments.Materials methods: Firstly,...
Debio0932 is a promising lead compound in phase I clinical trials targeting the N-terminal ATP-binding pocket of molecular chaperone heat-shock protein 90 (Hsp90 N ). The absence crystal structure Hsp90 –Debio0932 complex, however, has impeded further structural optimization and understanding molecular-interaction mechanism. Here, high-resolution complex was successfully determined (resolution limit 2.20 Å; PDB entry 6lr9) by X-ray diffraction mechanism analysed detail, which suggested that...
Abstract The crystal structure of a target‐ligand plays an indispensable role in rational drug design, structural optimization, and understanding the molecular interaction mechanism. For targets without structures, simulated 3D will provide alternative important reference. However, credibility its difference from real deserve deep consideration. complex structures target Hsp90 N four small inhibitors has previously been successfully determined. Herein, computer‐aided docking technology is...