A5066489190- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Head and Neck Cancer Studies
- Hearing Loss and Rehabilitation
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Glaucoma and retinal disorders
- Ear Surgery and Otitis Media
- Head and Neck Anomalies
- Cancer Immunotherapy and Biomarkers
- Cerebral Venous Sinus Thrombosis
- Brain Metastases and Treatment
- Tracheal and airway disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Teratomas and Epidermoid Cysts
- Noise Effects and Management
- Dysphagia Assessment and Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Body Composition Measurement Techniques
- Cardiac tumors and thrombi
- Adrenal and Paraganglionic Tumors
- Otolaryngology and Infectious Diseases
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Oral health in cancer treatment
Shinshu University
2016-2025
Ōtani University
2013-2024
Nagano Red Cross Hospital
2012
In-Q-Tel
2007
GTx (United States)
2007
<b><i>Background:</i></b> While hearing aids for a contralateral routing of signals (CROS-HA) and bone conduction devices have been the traditional treatment single-sided deafness (SSD) asymmetric loss (AHL), in recent years, cochlear implants (CIs) increasingly become viable choice, particularly countries where regulatory approval reimbursement schemes are place. Part reason this shift is that CI only device capable restoring bilateral input to auditory system hence...
The present study revealed that various etiologies are involved in single-sided deafness (SSD), and the cause of SSD asymmetrical hearing loss (AHL) differed greatly between congenital/early-onset cases adult cases. Clarification etiology is first step toward providing appropriate intervention.The aimed to clarify AHL patients.The a total 527 or patients who visited Shinshu University Hospital 2006 2016 were analyzed by imaging as well serological tests for mumps virus, CMV DNA testing.In...
Using a large-scale nationwide survey database, we investigated the epidemiological characteristics for idiopathic SSNHL in Japan.The subjects this analysis were patients registered Japanese multicentre database between April 2014 and March 2016. A total of 3419 clinical obtained. Several factors associated with severity hearing impairment prognosis then investigated. Statistical was performed to clarify prognosis.There significant correlations loss diabetes mellitus, kidney disease, past...
Abstract Objective To investigate sensorineural hearing loss in patients with head and neck cancer receiving chemoradiotherapy (CRT) a standard regimen of high-dose cisplatin, focusing on the acute changes before after CRT cisplatin (CDDP). Materials Methods A total of, 135 cases treated cisplatin-based between 2014 2023 were included this retrospective study. The threshold shifts at each frequency CDDP dose used as an indicator to assess impairment. Results CRT-induced shift was greater...
Mutations in the CDH23 gene are known to be responsible for both Usher syndrome type ID (USH1D) and non-syndromic hearing loss (DFNB12), molecular confirmation of has become important diagnosis these conditions. The present study was performed find whether mutations also patients Japanese population. A total 51 sequence variants were found 64 probands with sensorineural impairment from autosomal recessive families. Among them, at least four missense six five families confirmed deafness by...
Objectives: The aim of this study was to investigate the differences between idiopathic sudden sensorineural hearing loss (SSNHL), and acute low-tone (ALHL) using results a nationwide survey database in Japan analyze variables associated with their clinical features severity impairment, treatment, prognosis.Methods: Participants were patients registered April 2014 March 2016 multicenter epidemiological involving 30 university hospitals medical centers across Japan. Statistical analysis...
Conclusion Cochlear implantation (CI) for Japanese single-sided deafness patients resulted in improved speech perception, increased sound localization accuracy, and reduced tinnitus handicap. Objectives This study reports results five adult SSD cases with CI, focusing on the benefits they obtained terms of recognition, localization, Methods Five meeting eligibility criteria were included this study. All implanted a fully inserted MED-EL Concerto FLEX28® implant (MED-EL, Innsbruck, Austria)....
The majority of hearing loss due to mumps presents as unilateral profound sensorineural loss, which is refractory treatment. In rare cases bilateral total deafness, cochlear implants were beneficial for speech perception. Vaccination against recommended prevent mumps-associated loss.The objective this study investigate the clinical characteristics and evaluate outcomes.The parameters analyzed under a retrospective multi-institutional design in patients diagnosed with at Otolaryngology...
Objective: To investigate the hearing prognosis of idiopathic sudden sensorineural loss (SSNHL) treated with different initial therapies.Methods: Subjects consisted patients diagnosed SSNHL within 7 days from onset and showing severe (≥60 dB), who were registered in a Japanese multicenter database between April 2014 March 2016. divided into four groups according to therapy: (1) steroids, (2) steroids + Prostaglandins (PGs), (3) intratympanic (ITS), (4) no steroids. Hearing outcomes compared...
Objectives: A nationwide epidemiological survey involving 23 hospitals in Japan was conducted and the predictive values of demographic data were examined statistically.Methods: total 642 patients from hospitals, including 20 university enrolled study. Age ranged 8 to 87 years, all diagnosed with acute low-tone sensorineural hearing loss (ALHL) between 1994 2016. Demographic for patients, such as symptoms, gender, mean age, distribution ALHL grading, collected analyzed relation prognosis...
Lemborexant, an orexin receptor antagonist, is effective not only for sleep disorders but also preventing and treating delirium. To date, no complex sleep-related behaviors due to lemborexant have been reported. Herein, we present the case of a 69-year-old male patient who was hospitalized oral floor tongue cancer developed delirium after surgery; however, upon dosage increase, used treat insomnia, he abnormal nocturnal behavior. This symptom rapidly improved when discontinued....
To investigate the positive rate for Cochlin tomo-protein (CTP: an inner ear-specific protein) detection test among patients with ear-related clinical manifestations and evaluate characteristics of definite perilymphatic fistula (PLF).We have performed ELISA-based CTP using middle ear lavage (MEL) samples from 497 cases suspected PLF enrolled 70 centers nationwide between 2014 2015. In addition to CTP-positive rate, audio-vestibular symptoms were compared -negative cases.8-50% in category 1...
Background: To date, there have been few conventional algorithms for the treatment of idiopathic sudden sensorineural hearing loss (SSNHL), as only limited reports with high evidence levels.Objectives: propose an evidence- and trend-based algorithm SSNHL.Methods: We referred not to each treatment, but also trends related selection in Japan based on epidemiologic surveys, considered balance advantages disadvantages regard patient's condition.Results: that begins grade SSNHL severity prognosis...
Abstract This study aimed to investigate the prognostic value of hematological biomarkers measured before and after treatment in patients with head neck cancer (HNC). reviewed 124 HNC who received chemoradiotherapy. Hematological assessed were investigated. The pretreatment C-reactive protein/albumin ratio (pre-CAR) post-treatment nutritional index (post-PNI) showed highest area under curve cutoff values 0.0945 34.9, respectively. Patients high pre-CAR group significantly worse prognosis...
Hematohidrosis is a rare disorder characterized by bloody sweating on the skin without trauma. The ear, nose, and other facial areas are most commonly affected sites. This study shows usefulness of beta-blockers in treatment hematohidrosis.
Although anti-programmed death-1 (PD-1) antibody therapy improves the prognosis in patients with head and neck squamous cell carcinoma (HNSCC), some exhibit disease progression even after showing a good response to treatment initially because of acquired resistance. Here, we aimed reveal dynamic changes tumor microenvironment (TME) 77-year-old man diagnosed oral who developed resistance administration nivolumab using spatial transcriptomics. The results showed that, before immunotherapy,...
To investigate whether genetic polymorphisms (single-nucleotide polymorphism [SNPs]) have a prognostic influence on hearing recovery after standardized corticosteroid therapy.A total of 192 gene samples from idiopathic sudden sensorineural loss (SSNHL) patients registered in the Intractable Inner Ear Disease Gene Bank were enrolled and, as candidate genes, 16 SNPs 13 genes selected for this study. Fischer's exact test was used to compare allele frequencies each SNP between with good and poor...
Conclusion The results suggest that SOD1 rs4998557 could be associated with susceptibility to SSNHL in the Japanese population. Objectives To assess gene association sudden sensorineural hearing loss (SSNHL). Methods A two-stage case control study was conducted explore relationship of candidate genes SSNHL. 192 samples from patients registered intractable inner ear disease bank were enrolled. As genes, 39 SNPs 31 selected for first stage study. second examined whether polymorphisms, defined...
Background/Aim: Inflammation and nutrition-based biomarkers, such as the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), lymphocyte/monocyte (LMR), C-reactive protein/albumin (CAR), prognostic nutritional index (PNI), systemic immune inflammation (SII), response (SIRI), have value for several types of malignancies. Markers that precisely reflect prognosis patients with head neck cancers (HNCs) treated immune-checkpoint inhibitors remain unclear. This retrospective study aimed...