A5044903003- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Spinal Hematomas and Complications
- Spinal Dysraphism and Malformations
- Cerebral Palsy and Movement Disorders
- Neuroblastoma Research and Treatments
- Balance, Gait, and Falls Prevention
- Neurofibromatosis and Schwannoma Cases
- Landfill Environmental Impact Studies
- Chromatin Remodeling and Cancer
- Genomics and Chromatin Dynamics
- Stroke Rehabilitation and Recovery
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Analysis
- Intracranial Aneurysms: Treatment and Complications
- Infectious Diseases and Tuberculosis
- Hedgehog Signaling Pathway Studies
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Management of metastatic bone disease
- Geotechnical and Geomechanical Engineering
Katsushika Medical Center
2022-2024
Shibaura Institute of Technology
2019
Otsu Municipal Hospital
2009-2014
Kyoto first Red Cross hospital
2010
Taiyo Yuden (Japan)
2009-2010
Brain Tumour Research
2008
Hospital for Sick Children
2004-2008
Occupational Cancer Research Centre
2004
University of Toronto
2004
SickKids Foundation
2004
Abstract Purpose: The purpose of this study was to determine the relative contributions biological and clinical predictors survival in patients with medulloblastoma (MB). Experimental Design: Clinical presentation information were obtained for 119 who had undergone surgery MB at Hospital Sick Children (Toronto, Ontario, Canada) between 1985 2001. A tissue microarray constructed from tumor samples. arrays assayed immunohistochemical expression MYC, p53, platelet-derived growth factor...
We performed a retrospective observational study to demonstrate the surgical risks and long-term prognoses of intramedullary tumors in Japan using multicenter registry authorized by Neurospinal Society Japan.Data from 1,033 consecutive patients with tumors, treated between 2009 2020, were collected 58 centers. Patients spinal lipomas or myxopapillary ependymomas excluded. Patient characteristics, clinical presentations, imaging treatments, outcomes analyzed. The modified McCormick scale was...
Object Cancer testis antigens (CTAs) were initially identified by their ability to elicit autologous T-cell–mediated immune responses in patients with melanoma. The CTA genes are widely expressed a variety of human cancers, such as melanoma, breast cancer, lung esophageal and hepatocellular carcinoma; however, expression pediatric brain tumors, medulloblastoma (MB), has not been the subject in-depth analysis. MAGE proteins members family have shown correlate tumor development, aggressive...
The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the cytotoxic effect of alkylating agents on tumor cells. presence two nonconsensus glucocorticoid-responsive elements in human MGMT promoter region indicates potential regulation expression by glucocorticoid agents. This study was performed to elucidate whether dexamethasone affects glioblastoma multiforme (GBM) cells, thereby limiting benefit chemotherapeutic agents.Four GBM cell lines (A172, T98G, U138MG, and...
To quantitatively assess pathological gait, we developed a novel smartphone application for full-body human motion tracking in real time from markerless video-based images using monocular camera and deep learning. As training data learning, the original three-dimensional (3D) dataset comprising more than 1 million captured 3D of 90 humanoid characters two-dimensional COCO 2017 were prepared. The heatmap offset consisting 28 × blocks with three red-green-blue colors at 24 key points entire...
The JC virus is a human neurotropic polyomavirus that causes progressive multifocal leukoencephalopathy and closely related to simian 40. Several recent reports have indicated possible association between the development of various brain tumors. authors examined presence DNA sequences in primary tumors pediatric patients evaluate hypothesis particular can arise population as consequence infection with virus.Genomic were isolated from 62 (32 medulloblastomas, 18 ependymomas, five choroid...
Distinguishing pathological gait is challenging in neurology because of the difficulty capturing total body movement and its analysis. We aimed to obtain a convenient recording with an iPhone establish algorithm based on deep learning. From May 2021 November 2022 at Yamagata University Hospital, Shiga University, Takahata Town, patients idiopathic normal pressure hydrocephalus (n = 48), Parkinson’s disease 21), other neuromuscular diseases 45) comprised group 114), control consisted 160...
Glioblastomas rarely metastasize outside the CNS. We biologically characterized a case of secondary glioblastoma associated with extracranial progression and distant metastasis. A 42-year-old male patient was subjected to craniotomy for left temporal tumor (astrocytoma grade II) subsequently underwent another 3 craniotomies due recurrences. At third craniotomy, noted, classified as glioblastoma. In order pinpoint genes expressed differentially in intracranial primary metastatic tumors, we...
This paper presents a new approach in detecting moving objects at road intersections by using 360-degree view camera THETA. The is installed corner of the intersection. We have experimentally found that images from single THETA can capture all directions Furthermore, we propose method to detect images. Through real experiments, could confirm our methods such as pedestrians, bicycles and wheelchairs effectively, with small false positives rate.
To assess pathological gaits quantitatively, three-dimensional coordinates estimated with a deep learning model were converted into body axis plane projections. First, 15 healthy volunteers performed four gait patterns; that is, normal, shuffling, short-stepped, and wide-based gaits, the Three-Dimensional Pose Tracker for Gait Test (TDPT-GT) application. Second, of 47 patients idiopathic normal pressure hydrocephalus (iNPH) 92 elderly individuals in Takahata cohort assessed TDPT-GT....
To assess the current management of primary spinal cord tumors (PSCTs) and determine whether to what extent there are differences in surgical strategies for PSCTs.The Neurospinal Society Japan conducted a survey between April 1 30, 2021. Certified spine surgeons were requested information on frequency surgeries 2020 adopted each PSCTs. The following tumor histologies focused: schwannoma, meningioma, cauda equina as extramedullary tumors; ependymoma, hemangioblastoma, astrocytoma, cavernoma...
A 54-year-old man presented with a very rare case of radiation-induced intramedullary spinal cord anaplastic astrocytoma, which developed 37 years after radiotherapy for testicular seminoma. The patient weakness and numbness the left lower extremity that had gradually aggravated 3 months. Magnetic resonance imaging demonstrated an mass lesion syringomyelia at T9 to T12 levels. Subtotal removal tumor was performed using standard microsurgical technique. Histological examination revealed...
Occipital condyle fractures (OCFs) have been treated as rare traumatic injuries, but the number of reported OCFs has gradually increased because popularization computed tomography (CT) and magnetic resonance imaging (MRI). The patient in this report presented with C1 dislocation, along cerebellar hemorrhage, which led to craniovertebral junction instability. This case was also an extremely clinical condition lower cranial nerve palsy secondary OCFs. When transferred our hospital, occipital...
BACKGROUND Ganglioneuroma is a benign and well-differentiated tumor derived from neural crest cells, which occurs infrequently, with most patients being female adolescents. While predilection sites are the posterior mediastinum retroperitoneal cavity, ganglioneuroma originating dorsal root ganglion very rare. Here authors report case C2 ganglion-derived some literature review. OBSERVATIONS A 45-year-old male patient complained of persistent right-side throbbing occipital headache for more...
We aimed to capture the fluctuations in dynamics of body positions and find characteristics them patients with idiopathic normal pressure hydrocephalus (iNPH) Parkinson's disease (PD). With motion-capture application (TDPT-GT) generating 30 Hz coordinates at 27 points on body, walking a circle 1 m diameter was recorded for 23 iNPH, PD, 92 controls. For 128 frames calculated distances from navel other points, after Fourier transforms, slopes (the representatives fractality) were obtained...
The present case illustrates the incidental detection of a primary malignant melanoma thoracic spinal cord before central nervous system dissemination. A 54-year-old female fell down and bruised thoracolumbar region. patient visited local doctor underwent magnetic resonance imaging (MRI) lumbar spine to rule out vertebral fractures. MRI revealed no fracture, but an intradural extramedullary mass was observed at T12 level. She referred our hospital in October 2008. showed that appeared...
Introduction: Meningiomas and schwannomas are common intradural–extramedullary spinal tumors. Because of their different origins, they necessitate surgical procedures, which makes preoperative diagnosis important.
Pathological gait in patients with Hakim's disease (HD, synonymous idiopathic normal-pressure hydrocephalus; iNPH), Parkinson's (PD), and cervical myelopathy (CM) has been subjectively evaluated this study. We quantified the characteristics of upper lower limb movements pathological gait. analyzed 1491 measurements 1 m diameter circular walking from 122, 12, 93 HD, PD, CM, respectively, 200 healthy volunteers using Three-Dimensional Pose Tracker for Gait Test. Upper 2D coordinates projected...
BACKGROUND A bipartite atlas is a rare congenital anomaly characterized by incomplete fusion of the anterior and posterior arches first cervical vertebra (C1). While typically asymptomatic, this condition can result in myelopathy when accompanied degenerative changes. This report presents case caused an older patient that required surgical intervention. OBSERVATIONS 63-year-old male presented with progressive neurological symptoms, including impaired fine motor skills, pain, paresthesias...