A5088487885- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neural Engineering
- Neurobiology of Language and Bilingualism
- Fetal and Pediatric Neurological Disorders
- Neurological disorders and treatments
- Neurosurgical Procedures and Complications
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Spinal Dysraphism and Malformations
- Epilepsy research and treatment
- Semiconductor materials and devices
- Parkinson's Disease Mechanisms and Treatments
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- Language Development and Disorders
- Semiconductor Lasers and Optical Devices
- Advancements in Semiconductor Devices and Circuit Design
- Olfactory and Sensory Function Studies
- Spatial Neglect and Hemispheric Dysfunction
- 3D IC and TSV technologies
- Dementia and Cognitive Impairment Research
- Pharmacological Effects and Toxicity Studies
- Advanced MEMS and NEMS Technologies
Tohoku University
2012-2025
Tochigi Medical Center
2014-2020
Tohoku University Hospital
2014-2015
In-Q-Tel
2012
Hitachi (Japan)
2003-2006
Iwate University
2003
Dementia is one of the most debilitating symptoms Parkinson's disease. A recent longitudinal study suggests that up to 80% patients with disease will eventually develop dementia. Despite its clinical importance, development dementia still difficult predict at early stages. We previously identified olfactory dysfunction as important indicators cortical hypometabolism in In this study, we investigated possible associations between and risk developing within a 3-year observation period....
Frontal lobe dysfunction is believed to be a primary cognitive symptom in idiopathic normal pressure hydrocephalus (iNPH); however, the neuropsychology of this disorder remains fully investigated. The objective study was delineate comprehensive profile iNPH and evaluate effects cerebrospinal fluid (CSF) shunt surgery on dysfunction.A total 32 patients underwent neuropsychological testing memory, attention, language, executive function, visuoperceptual visuospatial abilities. Of these...
Background Visual hallucinations are a core clinical feature of dementia with Lewy bodies (DLB), and this symptom is important in the differential diagnosis prediction treatment response. The pareidolia test tool that evokes visual hallucination-like illusions, these illusions may be surrogate marker DLB. We created simplified version examined its validity reliability to establish utility test. Methods was administered 52 patients DLB, Alzheimer's disease (AD) 20 healthy controls (HCs)....
Infarctions of the posterior limb internal capsule (plIC) typically cause contralateral motor deficits. Cases with pure agraphia, writing impairments alone, are rare. We present a case agraphia as sole symptom after small infarction in anterior portion left plIC, which facilitates understanding interplay between subcortical and cortical networks controlling writing. This study evaluated 62-year-old right-handed Japanese man presenting difficulties typing In addition to neuropsychological...
Abstract Alzheimer’s disease (AD)-related primary progressive aphasia (PPA) exhibits considerable heterogeneity in clinical presentation and neuroimaging patterns. No studies have quantitatively assessed cerebral perfusion patterns or systematically evaluated the internal of linguistic features this population. This study aimed to investigate hypoperfusion elucidate their correlation with diverse patients AD-related PPA using a data-driven approach. Eleven 34 non-AD-related were categorized...
The aim of this study was to validate the Japanese version Addenbrooke’s Cognitive Examination-Revised (ACE-R) [Mori: <i>Japanese Edition Hodges JR’s Assessment for Clinicians</i>, 2010] designed detect dementia, and compare its diagnostic accuracy with that Mini-Mental State Examination. ACE-R administered 85 healthy individuals 126 patients dementia. reliability assessment revealed a strong correlation in both groups. internal consistency excellent (α-coefficient = 0.88)....
We have newly proposed heterogeneous multi-chip module integration technologies in which MEMS and LSI chips are mounted on Si or flexible substrates using a self-assembly method. A large numbers of were precisely simultaneously self-assembled bonded onto the with high alignment accuracy approximately 400 nm. Thick thickness more than 100 mum electrically connected by unique lateral interconnections formed crossing over chip edges step height. evaluated fundamental electrical characteristics...
We proposed 3D heterogeneous opto-electronic integration technology for system-on-silicon (SOS). In order to realize integrated (SOS), we developed novel of LSI, MEMS and optoelectronic devices by implementing multi-chip module composed with passives, devices. The electrical interposer mounted amplitude shift keying (ASK) LC filter pressure-sensing chips the optical embedded vertical-cavity surface-emitting laser (VCSEL) photodiode (PD) are precisely bonded form module. Opto-electronic...
Objectives The aim of this study was to develop and validate a bedside test for executive function in patients with idiopathic normal pressure hydrocephalus (INPH). Materials Methods Twenty consecutive INPH 20 Alzheimer's disease (AD) were enrolled study. We developed the counting-backward evaluating INPH. Two indices that are considered be reflective attention deficits response suppression underlying dysfunction calculated: first-error score reverse-effect index. Performance on both...
The aim of this study was to elucidate changes in cerebral white matter after shunt surgery idiopathic normal pressure hydrocephalus (INPH) using diffusion tensor imaging (DTI).Twenty-eight consecutive INPH patients whose symptoms were followed for 1 year placement and 10 healthy control (HC) subjects enrolled. Twenty the initial 28 shunt-responsive (SR) other 8 non-responsive (SNR). integrity detected by assessing fractional anisotropy (FA) mean diffusivity (MD). hemispheric DTI indices...
Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme in synthesis of γ-aminobutyric (GABA). Anti-GAD antibodies (GADA) are associated with progression stiff person syndrome and other neurological diseases, as well immune-mediated (type 1) diabetes. GABA one most widely distributed neurotransmitters, but non-motor symptoms GADA-positive patients not understood. Diabetes increasingly recognized a risk factor for dementia; however, relationship between diabetes dementia controversial....
Clamping and residual clamping forces of a Johnsen–Rahbek-type (JR-type) bipolar electrostatic chuck (ESC), which has electrically independent dual electrodes, were measured. Area ratios the ESC’s two electrodes ranged from 1 to 4.6. It was found that force per unit area decreases with increasing ratio increases ratio. To reveal mechanism force, an equivalent circuit model JR-type ESC devised. The showed is caused by charge results difference in monopolar ESCs. due resistance dependency on...
Abstract A number of vascular risk factors (VRFs) have been reported to be associated with idiopathic normal-pressure hydrocephalus (iNPH), but it remains unclear whether these VRFs are related patient outcomes after shunt surgery. Therefore, we investigated the for unfavourable surgery in iNPH patients using two samples from Tohoku University Hospital and a multicentre prospective trial lumboperitoneal (LP) (SINPHONI-2). We enrolled 158 patients. compared prevalence clinical measures...
The disproportionately enlarged subarachnoid space hydrocephalus (DESH) findings on cranial images are useful to predict cerebrospinal fluid (CSF) shunt responsiveness some extent in patients with idiopathic normal-pressure (iNPH). However, recent studies show that iNPH often have concomitant Alzheimer's or Lewy body disease regardless of DESH findings, which may be associated poor outcomes CSF surgery. Moreover, long-term after surgery iNPH, is one the most important issues addressed for...
Some patients with primary progressive aphasia (PPA) demonstrate only anomia. The lack of longitudinal observations anomic PPA precluded us from determining whether was simply an early stage semantic or logopenic variants, a relatively independent variant. Herein, we report the 10-year clinical course patient who presented pure for 9 years. He is right-handed man anomia, noticed word-finding difficulty at age 73. admitted to hospital 77. On admission, showed preserved other language...
We have developed a Si opt-neural probe with multiple waveguides and metal cover for highly accurate optical stimulation. This neural had 16 recording sites, three waveguides, suppressing light leakage. evaluated electrochemical properties of the confirmed that suitable characteristics recording. also demonstrated stimulation to neurons expressing ChR2 using our probe. As result, we succeeded multisite stimulation, observed no leakage from because cover. From in vivo experiments,...
This study aimed to examine echolalia and its related symptoms brain lesions in primary progressive aphasia (PPA).Forty-five patients with PPA were included: 19 nonfluent/agrammatic variant (nfvPPA), 5 semantic PPA, 7 logopenic 14 unclassified patients. We detected unstructured conversations. An evaluation of language function the presence parkinsonism, grasp reflex, imitation behaviour, disinhibition assessed. also measured regional cerebral blood flow (rCBF) using single-photon emission...
Lots of researchers take great interests in brain science. In this area, measurement devices the have been developed by number groups, and played an important role. Recently, for neuroengineering applications such as optogenetics, optical stimulation which consisted fibers reported, used to deliver light neurons expressing sensitive channel proteins. However, accurate could not be achieved using these because with a diameter over 100 μm. Here, we proposed novel Si neural probe micromachined...
The aim of this study was to investigate whether default mode network (DMN) connectivity and brain white matter integrity at baseline were associated with severe cognitive impairments poor outcomes after shunt placement in patients idiopathic normal pressure hydrocephalus (iNPH).Twenty consecutive iNPH whose symptoms followed for 6 months 10 healthy controls (HCs) enrolled. DMN the HCs detected by using resting-state functional magnetic resonance imaging (MRI) independent component analysis...