A5008074849- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Immunotherapy and Immune Responses
- Ocular Oncology and Treatments
- Head and Neck Cancer Studies
- Glioma Diagnosis and Treatment
- Occupational and environmental lung diseases
- Radiation Therapy and Dosimetry
- Cancer Immunotherapy and Biomarkers
- Radiation Dose and Imaging
- Virus-based gene therapy research
- Breast Cancer Treatment Studies
- Pleural and Pulmonary Diseases
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Cutaneous Melanoma Detection and Management
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Endometrial and Cervical Cancer Treatments
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
Städtisches Klinikum Dessau
2014-2025
University of Zurich
2008-2024
Medizinische Hochschule Brandenburg Theodor Fontane
2022-2024
Martin Luther University Halle-Wittenberg
2023
University Hospital of Zurich
1994-2022
Center for Pediatric Endocrinology Zurich
2014
Massachusetts General Hospital
2011
Radiation Oncology Associates
2009
University Hospital of Geneva
2008
Sorbonne Université
2008
Delivery of genetic expression constructs into living animals can effectively induce both humoral and cellular immunity to the expressed proteins. Here we test effectiveness immunization with a minigene coding for single epitopes derived from mutant p53 or HIV gp120. We show that when these are delivered by particle bombardment-mediated DNA transfer skin mice, it results in efficient induction tumor protective CTL. The immunogenicity epitope is significantly enhanced if sequence fused frame...
To define clinical outcome after definitive chemoradiotherapy (CRT) of anal carcinoma in HIV-infected patients treated with highly active antiretroviral therapy (HAART).A multicentric cohort comparison 40 HIV-positive HAART and 81 HIV-negative radiotherapy (RT) or CRT was retrospectively performed. Local disease control (LC), relapse-free survival (RFS), overall (OS), cancer-specific (CSS), toxicity, prognostic factors were investigated.HIV-positive younger (mean age, 48 v 62 years; P <...
Abstract BACKGROUND: A study was undertaken to assess clinical outcome and the role of proton therapy for local control osteosarcoma (OSA). METHODS: All patients who received or mixed photon‐proton radiotherapy from 1983 2009 at Massachusetts General Hospital were reviewed. Criteria need high dose in context highly conformal unresected partially resected OSA, positive postoperative margins, imaging studies with macroscopic disease, incomplete resection as defined by surgeon. The primary...
To determine the ability to induce tumor-specific immunity with individual mutant K-ras-or p53-derived peptides and monitor clinical outcome.Patients in varying stages of disease underwent genetic analysis for mutations K-ras p53. Thirty-nine patients were enrolled. Seventeen-mer custom synthesized corresponding mutation. Baseline was assessed cytotoxic T-lymphocyte (CTL) response interferon gamma (IFN-gamma) release from peptide-primed lymphocytes. Patients' peripheral-blood mononuclear...
We evaluated 715 glioblastoma patients diagnosed during 1980-1994 in the Canton of Zurich, Switzerland, to provide information on how were treated at population level. Despite a general policy study period treatment by surgical intervention aimed maximum tumor removal followed radiotherapy, there was marked tendency toward limited with advancing patient age. Of those younger than 65 years, 82% either surgery alone or radiotherapy alone, versus 47% years older. Only 25% older 75 underwent...
Stage III and stage IV thymomas with significant macroscopic infiltration to the neighboring structures are rarely completely resectable. It therefore remains unclear what extent tumors must be surgically debulked improve prognosis.We reviewed cases of 31 patients incompletely resected invasive thymoma residual disease who were referred postoperative irradiation. Survival local tumor control analyzed. All treated between 1958 1990 megavoltage irradiation at doses ranging from 42 66 Gy. The...
To report outcome (freedom from local progression [FFLP], overall survival [OS] and toxicity) after stereotactic, palliative or highly conformal fractionated (>12) radiotherapy (SBRT, Pall-RT, 3DCRT/IMRT) for adrenal metastases in a retrospective multicenter cohort within the framework of German Society Radiation Oncology (DEGRO). Adrenal treated with SBRT (≤12 fractions, biologically effective dose [BED10] ≥ 50 Gy), 3DCRT/IMRT (>12 BED10 Gy) Pall-RT (BED10 < were eligible this analysis. In...
Increased local production of granulocyte-macrophage colony-stimulating factor (GM-CSF) by genetically modified tumor cells can induce specific antitumor cellular immunity. We constructed a recombinant adenovirus expressing murine GM-CSF and tested it for therapeutic efficacy in syngeneic lung cancer model system. In vitro transduction Lewis carcinoma with adenovirus-mGM-CSF suppressed formation syngenic mice (C57BL/6), transduced irradiated induced regression pre-established wild-type...
Simple and efficient gene transfer to the skin would facilitate many local systemic therapy applications. Here we report a novel approach that allows installation expression of plasmid DNA without particulate carrier into for purposes therapy. A device with constantly high-frequency oscillating bundle fine metal needles puncturing leads skin-associated cells reporter genes in mice. Furthermore, puncture-mediated instillation an vector coding single T cell epitope induces specific cellular...
Abstract Background Impact of non-pharmacological innovations on cancer cure rates is difficult to assess. It remains unclear, whether outcome improves with 2- [18-F]-fluoro-2-deoxyglucose-positron emission tomography and integrated computer (PET/CT) intensity-modulated radiotherapy (IMRT) for curative treatment advanced pharyngeal carcinoma. Patients methods Forty five patients stage IVA oro- or hypopharyngeal carcinoma were staged an PET/CT treated definitive chemoradiation IMRT from 2002...
Purpose: To quantify interfractional anatomical variations and their dosimetric impact during the course of fractionated proton therapy (PT) prostate cancer to assess robustness current treatment planning techniques. Methods: Simulation daily in‐room CT scans from ten carcinoma patients were analyzed. PT plans (78 Gy in 39 fractions 2 Gy) created on simulation CT, delivering 25 PTV1 (expanded seminal vesicles), followed by 14 boost PTV2 prostate). Plans subsequently applied with beams...
The neutralizing immunoglobulin M (IgM) response to vesicular stomatitis virus (VSV) has been shown be largely T-cell independent in several T-cell-deficient models of mice. By using different antigen froms VSV, VSV doses could graded vivo (infectious > UV inactivated formalin inactivated). present study reveals a T-cell-dependent component the IgM nude mice given intravenous injections low noninfectious UV-inactivated serotype Indiana (VSV-IND) only if are transfused with VSV-IND-specific...