A5060081405- Glioma Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Gastric Cancer Management and Outcomes
- Cerebrospinal fluid and hydrocephalus
- Advanced Neuroimaging Techniques and Applications
- Brain Metastases and Treatment
- Digestive system and related health
- Cancer-related Molecular Pathways
- Head and Neck Surgical Oncology
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- Spinal Fractures and Fixation Techniques
- Peripheral Nerve Disorders
- Spinal Hematomas and Complications
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Neurobiology of Language and Bilingualism
- Moyamoya disease diagnosis and treatment
- Pituitary Gland Disorders and Treatments
- Neurosurgical Procedures and Complications
Fukui Prefectural Hospital
2020-2024
Kanazawa University
2010-2023
National Hospital Organization Kyushu Cancer Center
2023
Yokohama Sakae Kyosai Hospital
2022
Stony Brook University
2021
Neurological Surgery
2021
Twin Cities Orthopedics
2021
Shinshu University
2021
Kanazawa University Hospital
2004-2016
Kisarazu Hospital
2015
The authors’ recent discovery that glycogen synthase kinase‐3β (GSK‐3β) participates in colon cancer cells’ survival and proliferation prompted us to investigate whether GSK‐3β inhibition alters of cells vivo . Groups four or five athymic mice (Balb/c, nu/nu) with subcutaneous xenografts SW480 human were treated dimethyl sulfoxide (DMSO) different doses (1, 2 5 mg/kg body weight) either small‐molecule inhibitor (SB‐216763 AR‐A014418) by intraperitoneal injection three times per week for...
Abstract Purpose: Glioblastoma represents the malignant brain tumor that is most refractory to treatment and in which identification of molecular target(s) urgently required. We investigated expression, activity, putative pathologic role glycogen synthase kinase 3β (GSK3β), an emerging therapeutic target for neurodegenerative diseases, human glioblastoma. Experimental Design: The active fraction GSK3β phosphorylated at tyrosine 216 residue (pGSK3βY216) was identified glioblastoma cell lines....
Glycogen synthase kinase-3beta (GSK3beta) regulates multiple cell signaling pathways and has been implicated in glucose intolerance, neurodegenerative disorders, inflammation. We investigated the expression, activity, putative pathologic role of GSK3beta gastrointestinal, pancreatic, liver cancers.Colon, stomach, cancer lines; nonneoplastic HEK293 cells; matched pairs normal tumor tissues stomach colon patients were examined for expression its phosphorylation at serine 9 (inactive form)...
OBJECTIVE Although the right prefrontal region is regarded as a silent area, chronic deficits of executive function, including working memory (WM), could occur after resection glioma. This may be overlooked by postoperative standard examinations, and disabilities affect patient's professional life. The part frontoparietal network subserved superior longitudinal fasciculus (SLF); however, role SLF in spatial WM unclear. study investigated persistent deficit patients who underwent glioma...
// Takuya Furuta 1 , Hemragul Sabit Yu Dong Katsuyoshi Miyashita Masashi Kinoshita Naoyuki Uchiyama Yasuhiko Hayashi Yutaka Toshinari Minamoto 2 Mitsutoshi Nakada Department of Neurosurgery, Division Neuroscience, Graduate School Medical Science, Kanazawa University, Kanazawa, Japan Translational and Clinical Oncology, Cancer Research Institute, Correspondence to: Nakada, email: mnakada@med.kanazawa-u.ac.jp Keywords: glioblastoma, GSK3β, drug repositioning, translational research,...
Abstract Patients with glioma frequently present neuropsychological deficits preoperatively and/or postoperatively, and these may remain after the chronic phase. However, little is known about postoperative recovery course of right hemispheric function. We therefore studied characteristics causes persistent cognitive dysfunction in cerebral glioma. Eighteen patients who underwent awake surgery participated this study. All received preoperative examinations were assigned to two groups...
4514 Background: S-1 has been widely used against advanced gastric cancer (AGC) not only as monotherapy but also in combination with other cytotoxic compounds. Results of a phase I/II study combining + cisplatin (CDDP) were very encouraging high response rate (RR) 76%, and the MST (Median Survival Time) 383 days (Koizumi W et al, Br J Cancer, 2003). Based on these results, III comparing alone CDDP conducted to further evaluate efficacy safety for standard treatment AGC. Methods: This is...
✓ Solitary fibrous tumor (SFT) is a benign and rare neoplasm. To date, only 37 patients with intracranial SFTs have been reported. Although number of the tumors were recurrent some later underwent malignant transformation, none these lesions progressed to cerebrospinal fluid (CSF) dissemination. In this paper authors report case SFT in which lesion recurred several times ultimately was disseminated by CSF. The patient 63-year-old woman multiple spinal tumors. Fifteen years before...
Awake surgery could be a useful modality for lesions locating in close proximity to the eloquent areas including primary motor cortex and pyramidal tract. In case with supplementary area (SMA) lesion, we often encounter intraoperative symptoms during awake even without positive mapping. Although usual recovery of SMA syndrome has been well documented, rare cases permanent deficits encountered clinical setting. It difficult evaluate whether lead postoperative deficits. The purpose this study...
Glioblastoma (GBM) with primitive neuronal component (GBM‐PNC) is a rare GBM subtype recently categorized by the World Health Organization in revised classification system of 2016. Extracranial metastases originating from GBM‐PNC are and metastasis to solid organs has never been reported. Herein, we present first case lung. A 49‐year‐old man presenting headache was diagnosed multiple tumors adhering dura matter right temporal lobe. Despite surgery chemoradiotherapy, 2 months after initial...
S-1, a novel oral fluoropyrimidine, is well tolerated in patients with metastatic colorectal cancer (mCRC). The response rate of S-1 for high, ranging from 35% to 40%. This study aimed evaluate the safety and efficacy combined leucovorin (LV) enhance antitumor activity chemotherapy-naive mCRC.
Glycogen synthase kinase 3β (GSK3β) is a well-known marker and potential therapeutic target in non-insulin-dependent diabetes mellitus Alzheimer’s disease. Our recent demonstration that GSK3β has previously unrecognized role colorectal cancer facilitates the development of nonradioisotopic vitro assay (NRIKA) for detecting activity gastrointestinal cells. The NRIKA uses sequential combination immunoprecipitations to isolate sample cells’ lysates, an reaction recombinant β-catenin protein...