A5093006510- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Cardiovascular Health and Disease Prevention
- Functional Brain Connectivity Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
University of Manitoba
2023-2025
Aim Despite the clinical importance and significant social burden of neuropsychiatric symptoms (NPS) in dementia, underlying neurobiological mechanism remains poorly understood. Recently, neuroimaging‐derived brain‐age estimation by machine‐learning analysis has shown promise as an individual‐level biomarker. We investigated relationship between NPS amnestic mild cognitive impairment (MCI) early dementia. Methods In this cross‐sectional study, data, including inventory (NPI), structural...
White matter hyperintensities (WMHs) and cerebral microbleeds are widespread among aging population linked with cognitive deficits in mild impairment (MCI), vascular MCI (V-MCI), Alzheimer's disease without (AD) or a component (V-AD). In this study, we aimed to investigate the association between brain age, which reflects global health, cerebrovascular lesion load context of pathological diverse forms clinically-defined neurodegenerative conditions.
Abstract Background Despite the clinical importance and significant social burden of neuropsychiatric symptoms (NPS) in dementia, underlying neurobiological mechanism remains poorly understood. Recently, neuroimaging‐derived brain‐age estimation by machine‐learning analysis has shown promise as an individual‐level biomarker. We investigated relationship between NPS amnestic mild cognitive impairment (MCI) early dementia. Method Clinical data, including inventory (NPI), structural brain MRI...
Abstract Background Despite the clinical importance and significant social burden of neuropsychiatric symptoms (NPS) in dementia, underlying neurobiological mechanism remains poorly understood. Recently, neuroimaging‐derived brain‐age estimation by machine‐learning analysis has shown promise as an individual‐level biomarker. We investigated relationship between NPS amnestic mild cognitive impairment (MCI) early dementia. Method Clinical data, including inventory (NPI), structural brain MRI...
ABSTRACT INTRODUCTION White matter hyperintensities (WMHs) and cerebral microbleeds are widespread among aging population linked with cognitive deficits in mild impairment (MCI), vascular MCI (V-MCI), Alzheimer’s disease without (AD) or a component (V-AD). In this study, we aimed to investigate the association between brain age, which reflects global health, cerebrovascular lesion load context of pathological diverse forms clinically-defined neurodegenerative conditions. METHODS We computed...
Abstract Background We aimed to investigate the association between cortical brain age and white matter hyperintensities (WMH) in diverse forms of clinically‐defined vascular conditions. Our hypothesis was that a higher WMH burden would be associated with all clinical subtypes. Method used standardized MRI data obtained from participants COMPASS‐ND cohort CCNA. standard linear support vector regression algorithm estimate age, matching chronological anatomical measurements FreeSurfer toolbox...
Abstract Background We aimed to investigate the association between cortical brain age and white matter hyperintensities (WMH) in diverse forms of clinically‐defined vascular conditions. Our hypothesis was that a higher WMH burden would be associated with all clinical subtypes. Method used standardized MRI data obtained from participants COMPASS‐ND cohort CCNA. standard linear support vector regression algorithm estimate age, matching chronological anatomical measurements FreeSurfer toolbox...