A5009607973- Dementia and Cognitive Impairment Research
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Clinical practice guidelines implementation
- Mental Health and Psychiatry
- Brain Tumor Detection and Classification
- Health and Wellbeing Research
- Bipolar Disorder and Treatment
- Body Image and Dysmorphia Studies
- Health, Environment, Cognitive Aging
- Neurological Disorders and Treatments
- COVID-19 and Mental Health
- Pharmacy and Medical Practices
- Neurological Disease Mechanisms and Treatments
- Autoimmune Neurological Disorders and Treatments
- Neurology and Historical Studies
- Insurance and Financial Risk Management
- Obsessive-Compulsive Spectrum Disorders
- ECG Monitoring and Analysis
- Healthcare Decision-Making and Restraints
- Intergenerational Family Dynamics and Caregiving
- Parkinson's Disease Mechanisms and Treatments
- Hallucinations in medical conditions
- Neurological disorders and treatments
Osaka University
2021-2025
Abstract Background This study aimed to identify cases of potential prodromal DLB in very late-onset schizophrenia-like psychosis (VLOSLP), using indicative biomarkers dementia with Lewy bodies (DLB), and evaluate the characteristics as DLB. Methods Data patients VLOSLP without Parkinsonism, who underwent testing for at least one biomarker DLB, were retrospectively collected from database psychiatry clinic Osaka University Hospital. Patients divided into two groups based on positive...
Mild cognitive impairment (MCI) is a transitional state between normal ageing and dementia in cognition daily function. Patients with MCI initially exhibit subtle decline efficiency and/or accuracy performing activities of living (ADL), particularly those requiring complex functions, such as financial management food preparation.1, 2 These activities, referred to instrumental ADL (IADL), are affected prior basic (BADL) dressing bathing. Alzheimer's disease (AD) (ADD) demonstrate both BADL...
This study identifies neuropsychiatric syndromes and investigates their relationship with neuroimaging in Alzheimer's disease dementia (AD), Lewy bodies (DLB), mild cognitive impairment (MCI). Magnetic resonance imaging perfusion single-photon emission computed tomography data were collected for 281, 68, 180 patients AD, DLB, MCI, respectively, from three Japanese institutions. Neuropsychiatric Inventory was used exploratory factor analysis each group. Statistical Parametric Mapping...
<title>Abstract</title> <bold>Background:</bold> Hypersensitivity to antipsychotic drugs is one of the supportive features dementia with Lewy bodies, and side effects other than antipsychotics are also known occur frequently. We experienced a case bodies in which hallucinations delusions repeatedly appeared disappeared after administration discontinuation mirogabalin pregabalin. <bold>Case presentation: </bold>The patient, woman her late 70s, developed delusional misidentification places...
<title>Abstract</title> Background Dual-task composed of gait or stepping tasks combined with cognitive has been well-established as valuable tools for detecting neurocognitive disorders such mild impairment and early-stage Alzheimer’s disease. We previously developed a novel dual-task system high accuracy differentiating patients from healthy controls. In this study, we aimed to elucidate whether the output value obtained through artificial intelligence assumptions clinical meaning other...
ABSTRACT Objectives: We aimed to investigate the association between very late-onset schizophrenia-like psychosis (VLOSLP), a schizophrenia spectrum disorder with an onset of ≥60 years, and Alzheimer’s disease (AD) using biomarkers. Design: Retrospective cross-sectional study. Setting: Neuropsychology clinic Osaka University Hospital in Japan. Participants: Thirty-three participants were classified into three groups: eight AD biomarker-negative VLOSLP (VLOSLP−AD), nine biomarker-positive...
Objectives:We aimed to psychometrically evaluate and validate a Japanese version of the Social Functioning in Dementia scale (SF-DEM-J) investigate changes social function people with dementia during coronavirus disease-19 (COVID-19) pandemic.Design:We interviewed mild cognitive impairment (MCI) their caregivers June 2020–March 2021 patient- caregiver-rated SF-DEM-J compared scores at baseline (April 2020 May 2020) 6–8 months (January March 2021) time tighter COVID-19...
It is critical to develop accurate and universally available biomarkers for dementia diseases appropriately deal with the problems under world-wide rapid increasing of patients dementia. In this sense, electroencephalography (EEG) has been utilized as a promising examination screen assist in diagnosing dementia, advantages sensitiveness neural functions, inexpensiveness, high availability. Moreover, algorithm-based deep learning can expand EEG applicability, yielding automatic classification...
Visual hallucinations (VH) are associated with visual prediction error in patients dementia Lewy bodies (DLB). Given this relationship, environmental adjustments have been suggested, but detailed contents for implementing such and assessments poorly documented. This case report preliminarily demonstrates methods improving VH through our experience two DLB. We conducted familial interviews to assess the phenomenological features of reviewed photographs patients' homes identify triggers VH,...
Background/Objective: Behavioral and psychological symptoms of dementia (BPSD) have been reported to affect caregiver burden in patients with Lewy bodies (DLB). However, the factor structure BPSD factors that DLB remain unknown. This study sought classify reveal what type affects DLB. Methods: We collected data on neuropsychiatric inventory-plus (NPI-plus), Zarit Burden Interview (ZBI), Mini-Mental State Examination (MMSE), Lawton's Instrumental Activities Daily Living Physical...
Delusional infestation is characterized by delusions of being infested with parasites, vermin, or small insects and frequently accompanied tactile visual hallucinations. Herein, we report two cases dementia Lewy bodies (DLB) delusional infestation.Case 1 was an 83-year-old man. At the age 75, he began to show symptoms rapid eye movement sleep behavior disorder. 83, complain hallucinations people insects, resulting in use insecticides for non-existent insects. He also complained mild amnesia...
Early detection methods for cognitive impairment are crucial its effective treatment. Dual-task-based pipelines that rely on skeleton sequences can detect reliably. Although such achieve state-of-the-art results by analyzing of periodic stepping motion, we propose their performance be improved decomposing the sequence into representative phase-aligned periods and focusing them instead entire sequence. We present graph convolutional network, which is capable processing sequences. trained it...
Dementia and mild cognitive impairment (MCI) represent significant health challenges in an aging population. As the search for noninvasive, precise accessible diagnostic methods continues, efficacy of electroencephalography (EEG) combined with deep convolutional neural networks (DCNNs) varied clinical settings remains unverified, particularly pathologies underlying MCI such as Alzheimer's disease (AD), dementia Lewy bodies (DLB) idiopathic normal-pressure hydrocephalus (iNPH). Addressing...
<title>Abstract</title> This study aimed to examine the conversion rate dementia and cognitive changes in individuals with very late-onset schizophrenia-like psychosis (VLOSLP) classified Alzheimer's disease (AD) Lewy body (LBD) biomarkers. Patients VLOSLP were retrospectively enrolled study, follow-up assessments conducted at least once up approximately 2 years. Participants into AD LBD biomarker-negative (BMs-neg), AD-biomarker-positive (AD-pos/LBD-neg), biomarker-positive (LBD-pos)...
Objectives: Domestic squalor (DS) is related to physical problems, living alone, problems for their family and neighbors, mental illness, the most common of which dementia. Early intervention DS important; however, Methods detect treat older adults with remain unclear. This study aimed clarify early in DS. Methods: The Initial-phase Intensive Support Team Dementia (IPIST) a multidisciplinary outreach team that provides intensive initial assessment support people at home suspected dementia...
Background The occurrence of behavioral and psychological symptoms dementia is affected by individualized context. However, details regarding delusion theft have been poorly documented. This report describes a useful assessment to understand the environmental context through two cases Alzheimer's disease (AD). Familial interview was conducted assess phenomenological features. Photos patients' homes were used increase accuracy check contexts; this known as Photo Assessment Living Environment...
Abstract Background: Developing accurate and universally available biomarkers for dementia diseases is demanded under world-wide rapid increasing of patients with dementia. Electroencephalogram (EEG) offers promising examinations due to their inexpensiveness, high availability, sensitiveness neural functions. EEG applicability can be expanded by deep-learning.Methods: We analyzed signals based on novel deep network in healthy volunteers (HV, N=55), Alzheimer's disease (AD, N=101), Lewy...
Abstract Background We aimed to validate the Clinical Dementia Rating (CDR®) dementia staging instrument plus National Alzheimer's Coordinating Centre Behaviour and Language Domains (CDR® NACC FTLD) for use in clinical settings Japan Japanese language. Methods This prospective observational study enrolled 29 patients with frontotemporal (FTD) 21 disease (AD) from Departments of Psychiatry at Osaka University Hospital Asakayama General Brain Function Nippon Life Hospital. CDR® FTLD, CDR®,...
Objective: Diabetes mellitus (DM) is known to be one of the risk factors for cognitive decline and dementia. Neuropsychiatric symptom (NPS) present not only in dementia, but also mild impairment (MCI). In this study, we examined NPS MCI with DM compared our database investigate characteristics DM. Methods: The participants were subjects who diagnosed as from type 2 enrolled Osaka University Hospital. To estimate NPS, used Inventory (NPI) score. Results: number estimated was 19. According NPI...
Objective: The present study aimed to compare the social function between mild cognitive impairment (MCI), Alzheimer’s disease (AD) dementia, and dementia with Lewy bodies (DLB) using Japanese version of Social Functioning in Dementia scale (SF-DEM-J). Methods: We interviewed 103 patients family caregivers from June 2020 March 2021: 54 MCI, 34 AD 15 DLB. compared caregiver-rated SF-DEM-J, Clinical Rating (CDR), MMSE, age, length education, Geriatric Depression Scale (GDS), University...
Objective: The Intensive Initial Support Team for Dementia (IPIST) is a multidisciplinary outreach team that provides intensive initial assessment and support dementia in Japan, introduced based on the Memory Service UK. All municipalities are required to establish at least one team, which consists of physician two professional staffs such as public health nurses care workers. IPIST usually complete work within approximately six months, including consultation with medical specialists...