A5067538958- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Health Promotion and Cardiovascular Prevention
- Adipose Tissue and Metabolism
- Thermoregulation and physiological responses
- Dietary Effects on Health
- Body Composition Measurement Techniques
- Diabetes Management and Research
- Glycosylation and Glycoproteins Research
- Nutritional Studies and Diet
- Carbohydrate Chemistry and Synthesis
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Infant Nutrition and Health
- Chronic Disease Management Strategies
- Obesity and Health Practices
- Hemophilia Treatment and Research
- Enhanced Recovery After Surgery
- Pacific and Southeast Asian Studies
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Privacy, Security, and Data Protection
Osaka University
2015-2024
University of Tokyo Hospital
2016-2024
Public Health Department
2019-2023
National Defense Medical College
2009-2022
The University of Tokyo
2010-2022
Hyogo Prefectural Amagasaki General Medical Center
2007-2019
Health Affairs
2008-2013
Noguchi Institute
2003-2008
Visceral fat accumulation is associated with the development of metabolic disorders such as glucose intolerance, dyslipidemia, hypertension, and atherosclerotic cardiovascular diseases (1–8). However, relationship between reduction visceral decrease in number risk factors has not been defined general population. Recently, we developed a new technique, abdominal bioelectrical impedance analysis (BIA), to evaluate area (VFA) (9). The aim this study was investigate whether fat, estimated by...
Objective Visceral fat accumulation is an underlying component of the metabolic syndrome (MetS). Hypoadiponectinemia one key molecules MetS. In present study, we investigated relationship between serum uric acid level, visceral and adiponectin concentration in Japanese men. Patients Methods The study group comprised 1,520 employed men (mean age: 45.6±10.4 years, ± SD), who had undergone annual health check-up both 2004 2005. addition to parameters measured check-up, area (VFA) were by...
Abstract Objective this study explored whether the modification of selected lifestyles is likely to increase life expectancy from middle age onwards, regardless presence major comorbidities. Methods we examined a prospective cohort 20,373 men and 26,247 women aged 40–80 years. Eight modifiable lifestyle factors were assessed: consumption fruit, fish milk, walking and/or sports participation, body-mass index, smoking status, alcohol sleep duration. Modifiable healthy scored one point each,...
Lectin microarray is an emerging technique, which will accelerate glycan profiling and discovery of glycan-related biomarkers. One the most important stages in realizing potential technique to achieve sufficiently high sensitivity detect even low concentrations some target glycoproteins occur sera or tissues. Previously, we developed a lectin based on evanescent-field fluorescence-assisted detection principle that allows rapid glycoproteins. Here, report optimization procedures for spotting...
Heat stress could induce acute kidney injury. Although heat acclimation (HA) reportedly provides thermal tolerance, its effect on stress-induced damage remains unclear. This study showed that 5-day HA ameliorates mouse tubular and subsequent fibrosis caused by stress. It also demonstrated enhances intracellular shock protein 70 expression in cells prevents a decrease resident macrophages, which explains the renoprotective of HA.
The aim of this study was to evaluate the effects health checkup and education "Hokenshido" program based on concept that visceral fat accumulation causes metabolic syndrome (MetS), leading cardiovascular disease (CVD).Based Japanese definition syndrome, in annual for general subjects, measurement waist circumference use "Where am I?" chart way develop atherosclerosis were introduced. group comprised 3,174 employees [2,440 males (46±11 years, mean ± SD), 734 females (43±10 years)], who...
Abstract We investigated the cut‐off point of Matsuda Index in Japanese according to guideline from Clinical and Laboratory Standards Institute. A total 1,596 subjects free medications for diabetes mellitus, dyslipidemia and/or hypertension, without cardiovascular diseases or chronic renal failure underwent a health check‐up oral glucose tolerance test ( OGTT ). recruited 204 healthy reference individuals with normal obesity, any component metabolic syndrome elevated alanine...
Background : Parenteral nutrition (PN) causes intestinal mucosal atrophy, gut‐associated lymphoid tissue (GALT) atrophy and dysfunction, leading to impaired immunity increased susceptibility infectious complications. Therefore, new PN formulations are needed maintain immunity. Short‐chain fatty acids have been demonstrated exert beneficial effects on the mucosa. We examined of adding butyric acid GALT lymphocyte numbers, phenotypes, immunoglobulin A (IgA) levels, morphology in mice. Methods...
Aim: The accumulation of Visceral fat is known to precede metabolic disorders and atherosclerosis. This study aimed determine the relationships between body mass index (BMI), waist circumference (WC), estimated visceral area (eVFA) measured by bioelectrical impedance analysis (BIA), obesity-related cardiovascular risk factors.Methods: population was 2,870 middle-aged Japanese employees (males/females=2,322/ 548), who had undergone a health check-up.Results: In receiver operating...
Abstract Background Since heatstroke-induced acute kidney injury (AKI) can progress to chronic disease, it would be useful detect AKI and severe heat-related illness in the early phase. We studied epidemiology of among patients Japanese Ground Self-Defense Force evaluated relationship between severity urinary biomarkers for AKI. Methods enrolled who were diagnosed with at Fuji Hospital from 1 May 30 September 2020. compared molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin...
Abstract Aims/Introduction: Pronounced reduction of insulin secretion in response to a rise glucose level has been reported Japanese patients compared with Caucasian patients, but the mean body mass index (BMI) is also lower patients. As BMI determinant secretion, we examined insulin‐secretion capacity obese and non‐obese Materials Methods: Using oral tolerance test (OGTT), estimated insulin‐secreting (BMI ≥ 25) < including 1848 normal (NGT), 321 impaired (IGT) 69 diabetes (DM) Results:...
Circulating thiobarbituric acid-reacting substance (TBARS) levels, a marker of systemic oxidative stress, are predictive cardiovascular events. However, they has not been evaluated in Japanese, especially with regard to the factors that contribute changes circulating TBARS levels. We investigated cross-sectional and longitudinal relationships between levels various clinicobiochemical parameters middle-aged men. In this population-based study (The Amagasaki Visceral Fat Study), 1,178 Japanese...
The clustering of metabolic abnormalities occurs not only due to abdominal obesity but also other etiologies. We investigated the contribution visceral fat accumulation and circulating adiponectin level in a Japanese population.We used data for 1,989 employees perform structural equation modeling analysis. According concept syndrome, we developed multiple indicator cause (MIMIC) model what extent measurements area (VFA) levels explain morbidity abnormalities, represented as latent variable...
The use of ethnic-specific cutoff values waist circumference (WC) has been recently recommended, but they were originally developed on different statistical grounds. We investigated whether procedures and clinical settings generate WC in one ethnic population.We recruited 3810 Japanese subjects performed the following three analyses: 1) search for points associated with risk clustering metabolic abnormalities, 2) calculation certain body mass index (BMI) levels, 3) evaluation receiver...
Background: It is uncertain whether health counselling after community-based checkups for high-risk individuals of lifestyle-related disease enhances their referral to physicians.
A cluster randomized trial was conducted within 43 Japanese municipalities (21 intervention and 22 usual care) to examine whether the standardized health counseling for individuals at high cardiovascular risk screened community sites accelerates clinic visits strengthen primary care system.Among high-risk aged 40-74 years by checkups, 8,977 6,733 were allocated groups, respectively, who not under medical treatment but had levels of blood pressure (systolic/diastolic ≥ 160/100 mmHg),...
Preoperative carbohydrate (CHO) supplementation has been recommended in enhanced recovery after surgery protocols. However, the effects of CHO on gut and systemic immunity are not well understood.Mice (n = 60) were randomized to 1 following 5 groups: control (ad lib feeding), 12-hour fasting without administration (fasting), 12 hours with at 2, 4, 8 before sacrifice. Then, lymphocytes isolated from gut-associated lymphoid tissue, that is, Peyer's patches, intraepithelial space, lamina...
Background: Absence of enteral nutrition (EN) reduces hepatic mononuclear cell (MNC) numbers and impairs their functions. However, refeeding (ER) for as little 12 hours following parenteral (PN) rapidly restores MNC numbers. We hypothesized that changes in small intestine portal vein blood flows related to feeding route might be responsible this phenomenon. Methods: In experiment 1, mice (n = 19) were randomized Chow 5), PN 7) or ER groups. The group was given chow ad libitum with...