A5022657521- Thermoregulation and physiological responses
- Renal Diseases and Glomerulopathies
- Climate Change and Health Impacts
- Heat shock proteins research
- Platelet Disorders and Treatments
- Complement system in diseases
- Metabolism and Genetic Disorders
- Exercise and Physiological Responses
- Metabolomics and Mass Spectrometry Studies
- Sepsis Diagnosis and Treatment
- Pancreatic function and diabetes
- High Altitude and Hypoxia
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
- Sphingolipid Metabolism and Signaling
- Acute Kidney Injury Research
- Phagocytosis and Immune Regulation
- Diphtheria, Corynebacterium, and Tetanus
- Muscle metabolism and nutrition
- Immune cells in cancer
- Infective Endocarditis Diagnosis and Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Systemic Lupus Erythematosus Research
- Neuropeptides and Animal Physiology
- Thermal Regulation in Medicine
National Defense Medical College
2020-2025
Heat-related illnesses cause multiple organ injuries, including acute kidney injury (AKI). Recent studies have reported that heat-induced AKI can progress to chronic disease (CKD). We previously urinary levels of liver fatty acid-binding protein (L-FABP) are elevated in patients with severe heat-related illness. In this study, we prospectively examined the detection ability L-FABP rapid assay kit (L-FABP Point-of-Care [POC] kit) for damage prehospital settings. After applying exclusion...
Heat stress could induce acute kidney injury. Although heat acclimation (HA) reportedly provides thermal tolerance, its effect on stress-induced damage remains unclear. This study showed that 5-day HA ameliorates mouse tubular and subsequent fibrosis caused by stress. It also demonstrated enhances intracellular shock protein 70 expression in cells prevents a decrease resident macrophages, which explains the renoprotective of HA.
A major complication of heat-related illness is the development acute kidney injury (AKI) and damage to tubular cells. Because cells use fatty acids as a energy source, impaired acid oxidation (FAO) may be associated with due heat stress. Carnitine essential in transportation into mitochondria for FAO. To date, there has been little attention given role carnitine AKI. evaluate relationship between inadequacy severity or AKI, we examined serum levels patients illness. We also used...
IntroductionAnti-neutrophil cytoplasmic antibody (ANCA)–associated glomerulonephritis (GN) is characterized by pauci-immune crescentic GN. Although myeloperoxidase ANCA-associated GN (MPO-ANCA GN) with membranous nephropathy (MN), where bright granular capillary (MPO) and immunoglobulin G (IgG) staining along the glomerular basement membrane (GBM) present, has been reported; however, its clinicopathological features remain unclear.MethodsWe investigated 7 MPO-ANCA MN 11 control cases (6 5...
Abstract Background Since heatstroke-induced acute kidney injury (AKI) can progress to chronic disease, it would be useful detect AKI and severe heat-related illness in the early phase. We studied epidemiology of among patients Japanese Ground Self-Defense Force evaluated relationship between severity urinary biomarkers for AKI. Methods enrolled who were diagnosed with at Fuji Hospital from 1 May 30 September 2020. compared molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin...
Abstract The mortality rate for acute kidney injury (AKI) due to sepsis remains high, and effective therapies based on its pathogenesis remain elusive. Macrophages are crucial clearing bacteria from vital organs, including the kidney, under septic conditions. Excessive macrophage activation results in organ injury. C-reactive protein (CRP) peptide (174-185), a functional product of proteolyzed CRP vivo, effectively activates macrophages. We investigated therapeutic efficacy synthetic AKI,...
Abstract Background A percutaneous kidney biopsy (PKB) allows nephrologists to make informed decisions for treating various diseases; however, the risk of bleeding complications should be considered, given vascularity kidney. Many studies have reported factors events after a PKB. However, while urinary N-acetyl-β-D-glucosaminidase (NAG) is useful biomarker disease severity, little known about whether or not NAG related risk. Methods Medical records patients who underwent PKB at National...
This study reports a rare case of immune-complex mediated mesangial proliferative glomerulonephritis (ICGN) with full-house pattern in 56-year-old Japanese man, observed during the treatment immune thrombocytopenic purpura (ITP). Because persistent complement deficiency and worsening kidney function, he was treated prednisolone, his urinary findings improved markedly. However, as titers were still low, mycophenolate mofetil also prescribed, which normalized levels. Production anti-platelet...
Abstract This study reports a rare case of mesangioproliferative glomerulonephritis with full-house pattern in 56-year-old Japanese man. Mesangioproliferative was observed during the treatment immune thrombocytopenic purpura (ITP). After his diagnosis ITP 2012, abnormal urinary findings renal dysfunction were July 2018. His complement titers low, and he negative for antinuclear antibodies. A percutaneous biopsy performed January 2019. Light microscopy revealed mesangial cell proliferation...
Micrococcus speciesによるPD関連腹膜炎を発症した2例を経験したので考察を交えて報告する. 【患者1】61歳の男性. 糖尿病性腎臓病による末期腎不全で2017年11月から腹膜透析中. 導入11か月後にPD関連腹膜炎の診断で抗菌薬治療を開始した. 排液よりMicrococcus speciesが分離培養され, 感受性を有する抗菌薬に変更し, 第22病日に退院となった. 退院12日後に再度PD関連腹膜炎を発症し, vancomycin治療で改善せず第56病日にPDカテーテルを抜去した. 抜去後に炎症反応の上昇や腹痛は認めなかった. 【患者2】64歳の男性. 糖尿病性腎臓病による末期腎不全で2018年7月から腹膜透析中. 導入8か月後にPD関連腹膜炎の診断で抗菌薬治療を開始した. speciesが分離培養されたが, 治療が奏効し第16病日に退院となった. その後, 再発は認めていない. speciesによるPD関連腹膜炎は極めてまれである. 難治性腹膜炎になる可能性があり, PDカテーテル抜去を検討すべき場合もある.