A5010474854- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Heart Rate Variability and Autonomic Control
- Dialysis and Renal Disease Management
- Renal function and acid-base balance
- Parathyroid Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- Polymer Nanocomposites and Properties
- Dielectric materials and actuators
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Injection Molding Process and Properties
- Parvovirus B19 Infection Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Multiple Myeloma Research and Treatments
- Powder Metallurgy Techniques and Materials
- Electrolyte and hormonal disorders
- Systemic Lupus Erythematosus Research
- Microbial Metabolism and Applications
- Connexins and lens biology
- Heart rate and cardiovascular health
- Retinoids in leukemia and cellular processes
- Chronic Lymphocytic Leukemia Research
- Renal cell carcinoma treatment
Nippon Medical School
2024-2025
Jikei University School of Medicine
2020-2024
St. Luke's International Hospital
2023
Hyogo Prefectural Awaji Medical Center
2000
Keio University
1983-1987
Drug-induced tubulointerstitial injury is a common cause of renal impairment. Since the mechanisms drug-induced tubular are diverse, various treatment approaches needed according to pathogenesis. Renal biopsy indispensable determine not only pathological diagnosis, but also underlying mechanism, and guide appropriate treatment. Most recently, one red yeast supplements has been widely highlighted as novel damage, mainly in Japan Asia. However, neither detailed findings nor mechanism...
IntroductionAnti-neutrophil cytoplasmic antibody (ANCA)–associated glomerulonephritis (GN) is characterized by pauci-immune crescentic GN. Although myeloperoxidase ANCA-associated GN (MPO-ANCA GN) with membranous nephropathy (MN), where bright granular capillary (MPO) and immunoglobulin G (IgG) staining along the glomerular basement membrane (GBM) present, has been reported; however, its clinicopathological features remain unclear.MethodsWe investigated 7 MPO-ANCA MN 11 control cases (6 5...
Primary membranous nephropathy (pMN) is one of the most common types glomerulonephritis, with a third patients progressing to renal insufficiency. Various prognostic factors have been reported, which urinary protein and function are critical parameters. Fractional excretion total (FETP) indicates leakage that accounts for creatinine kinetics serum levels. In this study, we investigated association between FETP prognosis in pMN.
Immune checkpoint inhibitors (ICIs) can provide survival benefits to cancer patients; however, they sometimes result in the development of renal immune-related adverse events (irAEs). Tubulointerstitial nephritis (TIN) is most representative pathological feature irAEs. However, clinicopathological entity and underlying pathogenesis ICI-induced TIN are unclear. Therefore, we compared clinical histological features this condition with those non-ICI drug-induced TIN. Age C-reactive protein...
Key Points Albumin kinetics not only reflected the pathophysiology of minimal change nephrotic syndrome but was also a predictor relapse. The high estimated 24-hour albumin clearance predicts can easily be calculated from serum and urinary protein excretion, which are routine laboratory measurements. Background Although albuminuria leakage that occurs in (MCNS) may related to disease state, MCNS has never been evaluated. In this study, we investigated adult Japanese patients with by (eC ALB...
Summary We present an adult patient with haemophagocytic syndrome (HPS) successfully treated a combination of steroid pulse therapy and double filtration plasmapheresis (DFPP). A 58-year-old male was admitted high fever, severe renal dysfunction, liver dysfunction increased level lactate dehydrogenase. serological test for Epstein–Barr (EB) virus showed elevation EBNA-IgM antibody titre. There were histiocytes in the bone marrow addition to thrombocytopenia disseminated intravascular...
<title>Abstract</title> Background The interplay between cardiac and kidney functions is mediated by the autonomic nervous system. Cardiovascular neuropathy (CAN) a well-documented dysfunction of this system, with heart rate variability (HRV) serving as principal diagnostic tool. CAN recognised prognostic marker for adverse outcomes in diabetic disease (DKD). However, pathogenesis patients non-diabetic chronic (CKD) remains underexplored. This study explored clinicopathological correlates...
The interplay between cardiac and kidney functions is mediated by the autonomic nervous system. Cardiovascular neuropathy (CAN) a well-documented dysfunction of this system, with heart rate variability (HRV) serving as principal diagnostic tool. CAN recognized prognostic marker for adverse outcomes in diabetic disease (DKD). However, pathogenesis patients nondiabetic chronic (CKD) remains underexplored. This study elucidated prevalence its clinicopathologic characteristics CKD....
Background: Cardiovascular autonomic neuropathy (CAN) is common as the process of kidney injury. Coefficient variation R-R interval (CVR-R) one most convenient, noninvasive tests heart rate variability, and widely used to assess cardiac nerve function. However, clinical pathological findings in non-diabetic CKD patients with CAN has not been fully elucidated. This current study investigated characteristics diagnosed by CVR-R. Method: Subjects who underwent percutaneous biopsy performed CVR-R...
Kuno, Hideaki; Kanzaki, Go; Sasaki, Takaya; Okabayashi, Yusuke; Haruhara, Kotaro; Koike, Kentaro; Tsuboi, Nobuo; Yokoo, Takashi Author Information
Abstract Background and Aims Lower estimated glomerular filtration rate (eGFR) higher proteinuria are the most sensitive predictor of development progressive renal insufficiency in various diseases. On other hand, onset idiopathic membranous nephropathy (iMN) shows insidious progression, prognosis varies significantly. Therefore, it is difficult to predict outcome MN, using only severity proteinuria. Fractional excretion total protein (FETP), which was clearance divided by creatinine (Ccr),...