A5003199689- Renal Diseases and Glomerulopathies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Viral-associated cancers and disorders
- Bladder and Urothelial Cancer Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Medical Imaging and Pathology Studies
- Hydrogen's biological and therapeutic effects
- Cell death mechanisms and regulation
- Lymphoma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Urinary and Genital Oncology Studies
- Chronic Kidney Disease and Diabetes
- Uterine Myomas and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Soft tissue tumor case studies
- AI in cancer detection
- Tumors and Oncological Cases
- Vasculitis and related conditions
- IgG4-Related and Inflammatory Diseases
- Liver Disease and Transplantation
- Renal cell carcinoma treatment
- Sarcoma Diagnosis and Treatment
- Occupational and environmental lung diseases
- Peptidase Inhibition and Analysis
- Pediatric Urology and Nephrology Studies
Nippon Medical School
2016-2025
Nippon Medical School Hospital
2023
Kumamoto University
2006
Molecular hydrogen (H(2)) is an efficient antioxidant that diffuses rapidly across cell membranes, reduces reactive oxygen species (ROS), such as hydroxyl radicals and peroxynitrite, suppresses oxidative stress-induced injury in several organs. ROS have been implicated radiation-induced damage to lungs. Because prompt elimination of irradiation-induced should protect lung tissue from damaging effects irradiation, we investigated the possibility H(2) could serve a radioprotector lung. Cells...
Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is an autoimmune encephalitis, and 46% of women with anti-NMDAR have tumors, which 94% are ovarian teratomas. Patients rarely extra-ovarian teratomas, particularly mature cystic teratomas arising from the retroperitoneum. We herein report a 27-year-old woman who was diagnosed caused by teratoma In patients it important to perform systemic search, including for Plasma exchange significantly improved patient's clinical symptoms.
The accumulation of monocyte-derived macrophages in the lung tissue during inflammation is important for pathogenesis fibrotic disease. Deficiencies chemokine receptors CCR2 and CCR5 their ligands, which mediate monocyte/macrophage migration, ameliorate bleomycin (BLM)-induced fibrosis. Disulfiram (DSF), used to treat alcoholism because its aldehyde dehydrogenase (ALDH)-inhibiting effect, inhibits migration by inhibiting FROUNT, an intracellular regulator CCR2/CCR5 signalling. Here, we...
Nitric oxide (NO)-induced nitrative stress of nucleic acids, as evidenced by guanine nitration, appears to be involved in inflammation-induced carcinogenesis. A high incidence lung cancer idiopathic pulmonary fibrosis (IPF) is the major reason for poor prognosis patients with IPF.We immunohistochemically analyzed formation and localization 8-nitroguanine tissues from control subjects, IPF, cancer.Immunohistochemical analysis smoker nonsmoker lungs showed weak immunoreactivity 8-nitroguanine,...
IntroductionAnti-neutrophil cytoplasmic antibody (ANCA)–associated glomerulonephritis (GN) is characterized by pauci-immune crescentic GN. Although myeloperoxidase ANCA-associated GN (MPO-ANCA GN) with membranous nephropathy (MN), where bright granular capillary (MPO) and immunoglobulin G (IgG) staining along the glomerular basement membrane (GBM) present, has been reported; however, its clinicopathological features remain unclear.MethodsWe investigated 7 MPO-ANCA MN 11 control cases (6 5...
Activated monocytes/macrophages promote glomerular injury, including crescent formation, in anti-glomerular basement membrane (GBM) glomerulonephritis. Disulfiram, an alcohol-aversion drug, inhibits monocyte/macrophage migration by inhibiting FROUNT, a cytosolic protein that enhances chemokine receptor signaling. Our study found disulfiram at human equivalent dose successfully blocked albuminuria and formation with podocyte loss, later stage kidney fibrotic lesions, rat model of anti-GBM A...
Immune checkpoint inhibitors (ICIs) have provided significant benefits in cancer treatment, but they could develop immune-related adverse events (irAE). ICI-associated renal effects are rare and tubulointerstitial nephritis (TIN) is the most common irAE. However, only a few case reports of vasculitis associated with ICI been reported. In addition, characteristics infiltrating inflammatory cells TIN uncertain.A 65-year-old man received immune (ICIs), anti-CTLA-4 (cytotoxic...
To investigate associations between dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) expression and survival in T1 high-grade or T2 bladder cancer patients treated with neoadjuvant chemotherapy.The cohort under investigation comprised 44 who underwent chemotherapy for pT1 pT2N0M0 at our institution 2002 2011. Immunohistochemical analysis was used to determine of DYRK2 specimens obtained by transurethral resection before chemotherapy. Relationships both response these were...
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has recently been utilized to accurately detect the amyloid proteins of renal amyloidosis. The present study investigated optimal procedures for analyzing samples by LCMS/MS, and advantage using this technique diagnosis amyloidosis.To proteins, laser microdissected glomeruli from AL (n = 13) or AA 10) amyloidosis patients were digested analyzed LCMS/MS. To determine best we examined suitability tissue samples, frozen formalin-fixed...
Abstract Rheumatoid arthritis (RA)‐associated interstitial lung disease (ILD), a primary cause of mortality in patients with RA, has limited treatment options. A previously established RA model D1CC transgenic mice aberrantly expressed major histocompatibility complex class II genes joints, developing collagen II‐induced polyarthritis and anti‐cyclic citrullinated peptide antibodies pneumonitis, similar to those humans. Molecular hydrogen (H 2 ) is an efficient antioxidant that permeates...
Cholix toxin (Cholix) from Vibrio cholerae is a potent virulence factor exhibiting ADP-ribosyltransferase activity on eukaryotic elongation 2 (eEF2) of host cells, resulting in the inhibition protein synthesis. Administration or its homologue Pseudomonas exotoxin A (PEA) to mice causes lethal hepatocyte damage. In this study, we demonstrate cytotoxicity human hepatocytes presence tumor necrosis α (TNF-α), which has been reported play fatal role PEA administered mice. Compared with incubating...
Vibrio cholerae produced-Cholix toxin (Cholix) is a cytotoxin that ADP-ribosylates eukaryotic elongation factor 2, inhibiting protein synthesis, and inducing apoptosis. Here, we identified prohibitin (PHB) 1 2 as novel Cholix-interacting membrane proteins in immortalised human hepatocytes HepG2 cells by Cholix immunoprecipitation assays. The expression level of PHB1 was decreased after 12hr incubation. Cholix-induced poly (ADP-ribose) polymerase (PARP) cleavage significantly enhanced PHB...
Neoadjuvant chemotherapy has been shown to have benefit in T1 high-grade or T2 bladder cancer. However, neoadjuvant fails some patients. Careful patient selection for is therefore needed. Several reports show that Snail associated with resistance chemotherapy. We hypothesized expression could predict survival and cancer patients treated The participants were 44 receiving Immunohistochemical analysis was used determine specimens of obtained by transurethral resection before relationships...
Immune checkpoint inhibitors (ICIs) can provide survival benefits to cancer patients; however, they sometimes result in the development of renal immune-related adverse events (irAEs). Tubulointerstitial nephritis (TIN) is most representative pathological feature irAEs. However, clinicopathological entity and underlying pathogenesis ICI-induced TIN are unclear. Therefore, we compared clinical histological features this condition with those non-ICI drug-induced TIN. Age C-reactive protein...
Abstract Antibody responses, involving B cells, CD4 + T and macrophages, are implicated in autoimmune diseases organ transplant rejection. We have previously shown that inhibiting FROUNT with disulfiram (DSF) suppresses macrophage activation migration, effectively treating inflammatory diseases. In this study, we investigated the effectiveness of DSF antibody-producing reactions. Using a heart transplantation mouse model antibody-mediated rejection, administered anti-CD8 antibody to exclude...
Of the idiopathic interstitial pneumonias ( IIPs ), usual pneumonia UIP ) and diffuse alveolar damage DAD usually have poor prognoses. The prognoses of cryptogenic organizing COP nonspecific NSIP are more favorable. Although several reports described neovascularization in , this aspect has not been compared with . In study, we evaluated intra‐alveolar fibrotic lesion cases fibrosing (f‐ n = 26) 25). f‐ group, a considerable degree was observed to group bud type fibrosis showed greater...
Extranodal natural killer/T-cell lymphoma (ENK/TCL) is most often in the nose or nasopharynx but can present elsewhere. We report a rare case of ENK/TCL that presented as swelling an upper eyelid without ocular involvement. A 76-year-old man visited our hospital with swollen lesion left which had appeared 2 months earlier. biopsy revealed slight perivascular and periadnexal infiltration mononuclear cells dermal edema. Treatment oral prednisolone at dosage 20 mg/day decreased swelling....