A5024000939- Metallic Glasses and Amorphous Alloys
- High Entropy Alloys Studies
- Phase-change materials and chalcogenides
- Glass properties and applications
- High-Temperature Coating Behaviors
- Additive Manufacturing Materials and Processes
- Wound Healing and Treatments
- Intermetallics and Advanced Alloy Properties
- Pressure Ulcer Prevention and Management
- Diabetic Foot Ulcer Assessment and Management
- Titanium Alloys Microstructure and Properties
- Magnetic Properties of Alloys
- Nanoporous metals and alloys
- Metallurgical and Alloy Processes
- Semiconductor materials and interfaces
- Mineralogy and Gemology Studies
- Advanced materials and composites
- Nuclear Materials and Properties
- Reconstructive Surgery and Microvascular Techniques
- Ion-surface interactions and analysis
- Hedgehog Signaling Pathway Studies
- Developmental Biology and Gene Regulation
- Craniofacial Disorders and Treatments
- Semiconductor materials and devices
- Microstructure and mechanical properties
University of Hyogo
2021-2025
The University of Tokyo
2005-2024
Tachikawa Hospital
2022-2024
Osaka University
2014-2023
Fukui University of Technology
2023
Sakakibara Hospital
2022
Kyoto Prefectural University of Medicine
2021
Kyoto University
1974-2017
Cardiovascular Center Bethanien
2017
Graduate School USA
2016
Liposuction aspirates (primarily saline solution, blood, and adipose tissue fragments) separate into fatty fluid portions. Cells isolated from the portion are termed processed lipoaspirate (PLA) cells contain adipose-derived adherent stromal (ASCs). Here we define of liposuction as aspirate (LAF) cells. Stromal vascular fractions (SVF) were separately both portions characterized under cultured non-cultured conditions. A comparable number LAF PLA freshly isolated, but fewer adherent. CD34+...
A novel equiatomic TiNbTaZrMo high-entropy alloy (HEA) was developed as a new metallic biomaterial. The constituent elements of the HEA were biocomparable, and designed based on parameters such mixing enthalpy (ΔHmix), omega parameter (Ω), delta (δ), valence electron concentration (VEC) theory. bcc solid solution phases with different lattice constants obtained in as-cast annealed states. showed considerable strength deformability superior biocompatibility comparable to pure Ti. This study...
Nobel non-equiatomic Ti-Nb-Ta-Zr-Mo high-entropy alloys (HEAs) for metallic biomaterials (bio-HEAs) were designed and developed. The pseudo-binary phase diagrams focusing on solidification constructed by thermodynamic calculations. shifting the alloy composition of equiatomic TiNbTaZrMo bio-HEA can realize drastic improvement deformability. Notably, Ti, Zr-rich stimulated molecular interaction between biological cells bio-HEA, indicating possibility proposed HEAs as an advanced biomaterial...
Novel TiZrHfCr0.2Mo and TiZrHfCo0.07Cr0.07Mo high-entropy alloys for metallic biomaterials (bio-HEAs) were developed based on the combination of Ti-Nb-Ta-Zr-Mo alloy system Co-Cr-Mo as commercially-used biomaterials. Ti-Zr-Hf-Cr-Mo Ti-Zr-Hf-Co-Cr-Mo bio-HEAs designed using (a) a tree-like diagram development, (b) empirical parameters solid-solution-phase formation, (c) thermodynamic calculations focused solidification. The newly-developed overcomes limitation classical by improvement (i)...
Recent clinical studies implicate proteinuria as a key prognostic factor for renal and cardiovascular complications in hypertensives. The pathogenesis of hypertension is, however, poorly elucidated. Podocytes constitute the final filtration barrier glomerulus, their dysfunction may play pivotal role proteinuria. In present study, we examined involvement podocyte injury Dahl salt-hypertensive rats, an animal model prone to hypertensive glomerulosclerosis, explored effects inhibition...
Metabolic syndrome is an important risk factor for proteinuria and chronic kidney disease independent of diabetes hypertension; however, the underlying mechanisms have not been elucidated. Aldosterone implicated in target organ injury obesity-related disorders. This study investigated role aldosterone early nephropathy 17-wk-old SHR/NDmcr-cp, a rat model metabolic syndrome. Proteinuria was prominent SHR/NDmcr-cp compared with nonobese SHR, which accompanied by podocyte as evidenced foot...
The microstructures of equiatomic TiNbTaZrMo (Ti20Nb20Ta20Zr20Mo20—subscript numerals denote at.%) and non-equiatomic Ti2.6NbTaZrMo (Ti39.4Nb15.2Ta15.2Zr15.2Mo15.2) high-entropy alloys (HEAs) were investigated for use in metallic biomaterials, discussed based on their thermodynamics. Equiaxial dendrite structures observed the as-cast specimens. Ta, Nb, Mo abundant main phase with a body centered cubic (bcc) structure, while Ti Zr showed tendency to be inter-dendrite region bcc structure....
BioHEAs, specifically designed high entropy alloy (HEA) systems for biomedical applications, represent a new era biometals. However, recent challenges are (1) the poor shape customizability, and (2) inevitable severe segregation due to intrinsic fact that HEA is an ultra-multicomponent system. To achieve customization suppression of elemental simultaneously, we used extremely cooling rate (~107 K/s) selective laser melting (SLM) process. We, first time, developed pre-alloyed...
The fabrication of dense components composed Ti-based alloys, i.e., Ti-X (X = Cr, Nb, Mo, Ta) from a mixture pure elemental powders was achieved using selective laser melting (SLM) process. Ti-Cr alloys comprise β-Ti single-phase without any non-molten particles and macroscopic defects. crystallographic texture these β-Ti-Cr can be controlled effectively by optimizing the build parameters. development {001}〈100〉crystallographic orientation during SLM process is discussed based on...
Applying empirical alloy parameters (including Mo equivalent), the predicted ground state diagram, and thermodynamic calculations, noble nonequiatomic Ti–Zr–Hf–Nb–Ta–Mo high-entropy alloys for metallic biomaterials (BioHEAs) were designed newly developed. It is found that Moeq valence electron concentration (VEC) are useful design involving BCC structure formation in bio medium-entropy BioHEAs. Finally, we find a Ti28.33Zr28.33Hf28.33Nb6.74Ta6.74Mo1.55 (at.%) BioHEA exhibits biocompatibility...
The solidification microstructures of the TiNbTaZr medium-entropy alloy and TiNbTaZrX (X = V, Mo, W) high-entropy alloys (HEAs), including TiNbTaZrMo bio-HEA, were investigated. Equiaxed dendrite structures observed in ingots that prepared by arc melting, regardless position system. In addition, no significant difference microstructure was TiZrNbTaMo bio-HEAs between arc-melted (AM) cold crucible levitation melted (CCLM) ingots. A shut AM ingots, but not CCLM interdendrite regions tended to...
A super-high-entropy alloy (SHEA) with ΔSmix > 2.0R (where R is the gas constant) was designed to produce metallic materials superior mechanical properties conventional alloys. As an alternative quinary high-entropy alloys (HEAs), herein, octonary SHEAs for biomedical applications (BioSHEA) are proposed first time, and TiNbTaZrMoHfWCr BioSHEA fabricated. Arc-melted exhibited extremely high yield strength of 1953 ± 84 MPa, which approximately 500 MPa higher than that TiNbTaZrMo BioHEA. This...
A lattice distortion, represented by microstrain and parameter change, is frequently observed in nanocrystalline (NC) materials. In this letter, we develop a quantitative model to account for phenomenon. The internal stress induced the excess volume at grain boundaries suggested be main reason distortion. NC materials, prepared milling crystallization method, were used analysis comparison. Theoretical calculation shows reasonable agreement with experimental observations grain-size range from...
AlCoCrFeNi2.1 eutectic high-entropy alloy (EHEA) ingots were successfully obtained by high-frequency melting and centrifugal metal-mold casting under an Ar flow. The microstructure of the was investigated trans-scale observations using optical microscopy (OM), scanning electron (SEM), transmission (TEM), (STEM). constituent phases identified as fcc bcc X-ray diffraction (XRD) analysis, not dependent on position ingot. observed to have a primary dendrite fcc+bcc structure at inter-dendrite...
Deformation behavior of equiatomic HfNbTaTiZr high entropy alloy single crystals and polycrystals were investigated. The crystalline specimens could be obtained from the coarse-grained annealed just below melting point. 1/2<111> screw dislocations played an important role in deformation behavior, similar to body centered cubic (bcc) metals. Moreover, a yield stress anomaly was found appear alloys solutionized at 1473 K. decreased rapidly with increasing temperature up 673 K, while increased...
Koshima, Isao M.D.; Urushibara, Katsuyuki Fukuda, Norio Ohkochi, Masayuki Nagase, Takashi Gonda, Koichi Asato, Hirotaka Yoshimura, Kotaro M.D. Author Information