A5040333756- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Diabetes Management and Research
- Diabetes and associated disorders
- Asymmetric Synthesis and Catalysis
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Pancreatitis Pathology and Treatment
- Synthetic Organic Chemistry Methods
- Pancreatic and Hepatic Oncology Research
- Sodium Intake and Health
- Bariatric Surgery and Outcomes
- Nutritional Studies and Diet
- Body Contouring and Surgery
- Synthesis of heterocyclic compounds
- Cardiovascular Disease and Adiposity
- Pharmacology and Obesity Treatment
- Chemical Synthesis and Reactions
- Cardiovascular Health and Disease Prevention
- Biochemical and Molecular Research
- Diabetes Management and Education
- Diet, Metabolism, and Disease
- Organic and Inorganic Chemical Reactions
- Chemical Reaction Mechanisms
- Lipid metabolism and disorders
Osaka University
2012-2024
Keio University
2021-2023
Aichi Medical University
2015-2017
Doshisha Women's College of Liberal Arts
2010
Niigata University
2010
Radiation Effects Research Foundation
1998-1999
Okayama University of Science
1993-1997
Kobe Gakuin University
1996
A decrease in pancreatic β-cell mass is involved the development of type 2 diabetes.The purpose this study was to evaluate and incidence neogenesis, replication, apoptosis at both prediabetic diabetic stages.We conducted a cross-sectional tissues obtained from 42 patients undergoing pancreatectomy who were classified into 4 groups: normal glucose tolerance (n = 11), impaired newly diagnosed diabetes 10), long-standing 10).The relative area decreased increased during diabetes. The number...
Immune checkpoint inhibitors (ICIs) could cause type 1 diabetes (T1D). However, the underlying mechanism remains unclear. We immunohistochemically analyzed pancreatic specimens from three individuals with ICI-related T1D, and their histopathological data were compared those patients who had received ICI therapy but did not develop T1D (non-T1D) seven normal glucose-tolerant subjects as control subjects. All susceptible HLA haplotypes. In β-cell area decreased α-cell increased non-T1D The...
We aimed to clarify the relationship between intra- and periorgan fats, visceral fat, subcutaneous fat. used abdominal computed tomography evaluate fat accumulations in pancreas, liver, spleen, renal parenchyma, sinus, skeletal muscle. The relationships these were examined by using partial correlation covariance analysis, adjusting for BMI. found that all positively correlated, whereas of fats negatively correlated. Individuals with excessive accumulation had significantly greater muscle...
A 70-year-old man developed anorexia, general malaise, and hyponatremia with a serum sodium level of 120 mEq/L after the fifth cycle pembrolizumab administration for bladder cancer. rapid adrenocorticotropic hormone (ACTH) loading test result was within normal range (basal peak cortisol levels 8.2 μg/dL 20.0 μg/dL, respectively), his recovered by salt loading. However, about two weeks later, anorexia malaise worsened, decreased to 122 mEq/L. ACTH performed again four first showed 13.4...
Background and objective Pancreatic fat is a form of ectopic fat. Lipid droplets (LDs) are also observed in β cells; however, the pathophysiological significance, especially for cell function, has not been elucidated. Our aim was to assess LD accumulation cells various stages glucose intolerance clarify its relationship with clinical histological parameters. Methods We examined 42 Japanese patients who underwent pancreatectomy. The BODIPY493/503-positive (BODIPY-positive) area measured...
The relationship between pancreatic fatty infiltration and diabetes is widely known, whereas the causal not clear. Furthermore, it uncertain whether pathogenesis of fat similar to that liver fat. We aimed clarify contribution this type glucose metabolism in 2 patients by cross-sectional longitudinal analyses.
Chronic inflammation is observed in type 2 diabetes islets, and fat deposition the pancreas affects insulin secretion glucose tolerance. However, relationship between this pancreatic has not been elucidated.We examined sections from 60 Japanese patients obtained by pancreatectomy. We evaluated fat-cell area (%) CD68-positive (CD68+) cells per islet histologically relationships these histological findings various clinical parameters.The number of CD68+ group was significantly higher than that...
This study aimed to assess the long-term effects of tofogliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, on atherosclerosis progression and major clinical parameters in patients with type diabetes lacking an apparent history cardiovascular disease.This was prospective observational 2-year extension "Using TOfogliflozin for Possible better Intervention against Atherosclerosis (UTOPIA)" trial, randomized intervention study. The primary endpoints represented changes carotid...
Pancreatic beta-cell mass contributes to glucose tolerance. The aim of this study was evaluate the relationships between human and various clinical parameters, including insulin secretory capacity. included 32 Japanese patients who underwent pancreatectomy were naive oral hypoglycemic agents insulin. They classified into those with normal tolerance (n=13), impaired (n=9) diabetes (n=10), their capacity resistance evaluated. Immunohistochemistry used determine relative area (%) which...
Pancreatic α-cell area and the α- to β-cell ratio (α/β) might be associated with glucose tolerance. The aim was clarify how these histological parameters change as tolerance deteriorates.We analyzed pancreatic tissues obtained from pancreatectomies of 43 patients. We evaluated relationships between or α/β various clinical parameters. Additionally, we proliferation expression patterns transcription factors.The in individuals longstanding (previously diagnosed) type 2 diabetes (0.36 ± 0.12)...
We herein describe a 59-year-old woman who had undergone total gastrectomy for gastric carcinoma and suffered from postprandial hypoglycemia characterized by loss of consciousness spasms. She was diagnosed with reactive treated nutrition therapy, but the frequency severity hypoglycemic episodes did not decrease. subsequently successfully miglitol, an alpha-glucosidase inhibitor (α-GI) taken twice day; other α-GIs (acarbose voglibose) were effective. In conclusion, administration miglitol...
We herein report the case of a 41-year-old male patient with an incidentally identified large adrenal ganglioneuroma (GN). His endocrine examinations were normal except for one episode elevated urinary dopamine and noradrenaline levels. Abdominal computed tomography (CT) magnetic resonance imaging (MRI) showed solid tumor calcifications slightly lobular edge in right gland. performed open excision diagnosed it as ganglioneuroma. Adrenal GN is rare benign tumor, its hormonal activity...
Abstract Background Ectopic fat is that accumulates in or around specific organs compartments of the body including myocardium. The clinical features type 2 diabetes patients with high accumulation myocardium remain unknown. Moreover, little known about influence myocardial on coronary artery disease and cardiac dysfunction. We aimed to clarify features, functions, accumulation. Methods retrospectively enrolled who underwent ECG-gated computed tomography angiography (CCTA) abdominal (CT)...
Background & aimsEctopic fat deposition is associated with worsening of glycemic control. This study was conducted to determine whether liraglutide reduces ectopic deposition, especially in pancreas, patients type 2 diabetes (T2D).MethodsWe retrospectively recruited T2D who underwent abdominal unenhanced CT scans both before and after administration (N = 13) or glimepiride 29). Using values pancreas (P), liver (L) spleen (S), we defined the indices intrapancreatic as P–S value L-S value,...
Various oral glucose-lowering agents are available in Japan. Although the objective characteristics of these drugs well described, little is known about treatment satisfaction by patients using agents. The aim this study was to assess diabetic visiting diabetes clinics Diabetes Treatment Satisfaction Questionnaire (DTSQ) and determine association DTSQ scores with various factors including subjects were 754 outpatients who had been treated one or more agents, but not insulin glucagon-like...
Treatment-related quality of life (QOL) is an important aspect diabetes management. We evaluated the influence a sodium-glucose cotransporter 2 (SGLT2) inhibitor, tofogliflozin, on treatment-related QOL in Japanese patients with type mellitus (T2DM). This prespecified subanalysis study "Using TOfogliflozin for Possible better Intervention against Atherosclerosis (UTOPIA)" trial. was at baseline, week 26, 52, and 104 after initiation using Diabetes Therapy-Related questionnaire (DTR-QOL)....
Abstract Pancreatic islet cells have plasticity, such as the abilities to dedifferentiate and transdifferentiate. Islet cell conversion other characteristic is largely determined by transcription factors, but significance of expression patterns these factors in human remained unclear. Here, we present NKX6.1-positive ratio glucagon-positive (NKX6.1 + /GCG ratio) ARX-negative (ARX − 34 patients who were not administered antidiabetic agents. Both NKX6.1 ARX negatively associated with relative...
Background This pilot study examined the feasibility of a new lifestyle modification program involving “Teaching Kitchen” in Japan. Our goal was to explore (1) program; (2) acceptability for class frequency (weekly vs. bi-weekly); and (3) changes biometrics, dietary intakes, factors. Methods A total 24 employees with obesity Japanese company were recruited. Participants randomly divided into two groups or bi-weekly group), each attending consisting four two-hour classes (lectures on...
Introduction This study aimed to identify the associations between lifestyle factors and intrapancreatic fat deposition in patients with type 2 diabetes. Research design methods The participants were 185 diabetes who hospitalized at Osaka University Hospital 2008 2020 underwent abdominal CT during hospitalization. Information regarding factors, including number of meals consumed per day, snacking habits, exercise work, smoking alcohol intake, insomnia, sleep apnea syndrome, night-shift...