A5019140886- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- T-cell and Retrovirus Studies
- Immunodeficiency and Autoimmune Disorders
- PI3K/AKT/mTOR signaling in cancer
- Protein Degradation and Inhibitors
- CNS Lymphoma Diagnosis and Treatment
- Blood disorders and treatments
- Hematopoietic Stem Cell Transplantation
- Esophageal Cancer Research and Treatment
- Macrophage Migration Inhibitory Factor
- S100 Proteins and Annexins
- Nutrition, Genetics, and Disease
- Cancer Immunotherapy and Biomarkers
- Nuclear Receptors and Signaling
- Congenital heart defects research
Osaka International Cancer Institute
2023-2024
Osaka University
2022-2024
Keio University
2014-2023
New York University
2020-2023
National Center for Global Health and Medicine
2020-2022
Sumitomo Hospital
2011-2019
Tachikawa Hospital
2018
Keio University Hospital
2015
Data Harbor (United States)
2015
Japan Science and Technology Agency
2014
Transplantation of endothelial cells (ECs) is a promising therapeutic approach for ischemic disorders. In addition, the generation ECs has become increasingly important providing vascular plexus to regenerated organs, such as liver. Although many attempts have been made generate from pluripotent stem and nonvascular cells, minimum number transcription factors that specialize in directly inducing remains undefined. Here, by screening 18 are both hematopoietic development, we demonstrate ets...
Antigen-specific regulatory T cells (Tregs) possess the potential to reduce excess immune responses in autoimmune diseases, allergy, rejection after organ transplantation and graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation. Although vitro-expanded antigen-specific induced Tregs (iTregs) have been considered be a promising therapeutic agent against such excessive reactions, instability of iTregs transfer is fundamental problem their clinical application. In...
Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically aggressive with an unfavorable prognosis. We report the case of 50-year-old woman who was diagnosed IVLBCL during treatment methotrexate (MTX) biologic agents for rheumatoid arthritis. The symptoms showed partial improvement only after cessation both treatments. She subsequently received chemotherapy achieved complete remission has remained free recurrence 2 years without any further treatment. herein describe which...
Calcineurin inhibitors (CNIs), used as immunosuppressants, have revolutionized transplantation medicine with their strong suppressive activity on alloreactive T lymphocytes; however, they may also cause various adverse effects, including an increased risk for infection and nephrotoxicity. Regulatory (Treg) cells can complement the deleterious side effects of CNIs effective Ag-specific activities. However, several studies shown that suppress Treg cell differentiation. Therefore, understanding...
Abstract Although the introduction of tyrosine kinase inhibitors (TKIs) has improved overall survival patients with chronic myeloid leukemia (CML), about half eventually relapse after cessation TKIs. In contrast, remainder maintain molecular remission without TKIs, indicating that patients’ immune system could control proliferation TKI-resistant leukemic stem cells (LSCs). However, precise mechanism immunity against CML-LSCs is not fully understood. We have identified a novel target,...
An inguinal lymph node biopsy of a woman with one-month history progressive fever, fatigue, dyspnea, skin rash, and lymphadenopathy revealed well-preserved basic structure, hyperplastic germinal centers, an interfollicular region containing polyclonal plasma cell sheets, suggesting cell-type multicentric Castleman disease (MCD). We initiated prednisolone anti-interleukin (IL)-6 antibody (tocilizumab), without success. A specimen re-evaluation detected CD20-positive atypical large B cells...
We experienced a patient with angioimmunoblastic T-cell lymphoma (AITL) without Epstein-Barr virus-positive B (EBV-B) cells at initial presentation who progressed to AITL expansion of EBV-B relapse. Based on the results repeated biopsy, was successfully treated rituximab in combination chemotherapy A repeat biopsy may be necessary determine optimum therapeutic strategy relapse, particularly for patients suspected cell and/or cells. Although recent report found no significant prognostic...
ABSTRACT Background Infectious diseases remain a major cause of morbidity and mortality after hematopoietic cell transplantation (HCT). Secondary hypogammaglobulinemia is risk factor for infectious diseases. Total immunoglobulin G (IgG) levels the history are an integral part determining indication replacement therapy. The clinical significance IgG2 not well established. Guidelines recommend using pathogen‐specific IgG to evaluate patients with potential secondary immunodeficiency. However,...
As a MYH9 disorder, Fechtner syndrome is characterized by nephritis, giant platelets, granulocyte inclusion bodies (Döhle-like bodies), cataract, and sensorineural deafness. Observation of peripheral blood smear for the presence thrombocytopenia, bodies) highly important early diagnosis disorders. In our two cases, sequencing analysis gene indicated mutations in exon 24. Both cases were diagnosed as disorders before end-stage renal failure on basis observation smear.
A 73-year-old Japanese man was admitted to the hospital in June 2010.He complained of general fatigue, high fever, weight loss 10 kg 2 months, and right lower abdominal pain without diarrhea that had been ongoing for several months before admission.He denied alcohol abuse or risk factors HIV.He type diabetes mellitus controlled by insulin, as well hypertension, previous myocardial infarction, current mild dementia.He traveled extensively developing countries about 30 years before.Tests HIV...