A5070679322- Immune Response and Inflammation
- Tracheal and airway disorders
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Natural Compounds
- Trauma Management and Diagnosis
- Redox biology and oxidative stress
- Cytokine Signaling Pathways and Interactions
- Congenital Heart Disease Studies
- Psoriasis: Treatment and Pathogenesis
- Mechanical Circulatory Support Devices
- interferon and immune responses
- Nutrition and Health in Aging
- Advanced Glycation End Products research
- Fungal Biology and Applications
- Aortic Disease and Treatment Approaches
- Congenital Diaphragmatic Hernia Studies
- Diabetes Management and Research
- Inflammasome and immune disorders
- Cardiac Arrest and Resuscitation
- S100 Proteins and Annexins
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
Osaka University
2018-2023
Keio University
2011-2015
Keio University Hospital
2012
Japan Science and Technology Agency
2012
Kawasaki Hospital
2010
Kawasaki Municipal Hospital
2010
Cytokines play essential roles in innate and adaptive immunity. However, excess cytokines or dysregulation of cytokine signaling will cause a variety diseases, including allergies, autoimmune inflammation, cancer. Most utilize the so-called Janus kinase-signal transducers activators transcription pathway. This pathway is negatively regulated by various mechanisms suppressors (SOCS) proteins. SOCS proteins bind to JAK receptors, thereby suppressing further events. Especially, suppressor...
Post-ischemic inflammation is an essential step in the progression of brain ischemia-reperfusion injury. In this review, we focus on post-ischemic triggered by infiltrating immune cells, macrophages, and T lymphocytes. Brain ischemia a sterile organ, but injury-induced mostly dependent Toll-like receptor (TLR) 2 TLR4. Some endogenous TLR ligands, high mobility group box 1 (HMGB1) peroxiredoxin family proteins, particular, are implicated activation inflammatory cytokine expression...
Tracheostomy is commonly performed in critically ill patients because of its clinical advantages over prolonged translaryngeal endotracheal intubation. Early tracheostomy has been demonstrated to reduce the duration mechanical ventilation and length stay. However, association with mortality remains ambiguous. This study aimed evaluate between timing receiving ventilation.We a retrospective cohort analysis adult who underwent during their intensive care unit (ICU) admission April 2015 March...
Heterogeneity is an inherent nature of ARDS. Recruitment-to-inflation ratio has been developed to identify the patients who lung recruitablity. This technique might be useful that match specific interventions, such as higher positive end-expiratory pressure (PEEP) or prone position both. We aimed evaluate physiological effects PEEP and body on mechanics regional inflation in COVID-19-associated ARDS propose optimal ventilatory strategy based recruitment-to-inflation ratio.Patients with were...
Abstract Lipopolysaccharide (LPS)-induced acute lung injury (ALI) is known as a mouse model of respiratory distress syndrome; however, the function T-cell-derived cytokines in ALI has not yet been established. We found that LPS challenge one resulted rapid induction innate-type pro-inflammatory such IL-6 and TNF-α, followed by expression T-cell-type cytokines, including IL-17, IL-22 IFN-γ. discovered IL-23 important for ALI, since blockage gene disruption or anti-IL-12/23p40 antibody...
The aryl hydrocarbon receptor (AhR), a ligand-activated nuclear transcription factor, is known to mediate the toxic and carcinogenic effects of various environmental pollutants, while AhR has been shown protect animals from types tissue injury. ConA-induced hepatitis as mouse model acute liver Here, we found protective role in hepatitis. induced during hepatitis, Ahr (-/-) mice were highly sensitive this model. Bone marrow chimera experiments indicate that hematopoietic cells are responsible...
The cuff leak test (CLT) has been widely accepted as a simple and noninvasive method for predicting post-extubation stridor (PES). However, its accuracy clinical impact remain uncertain. We aimed to evaluate the reliability of CLT assess pre-extubation variables on incidence PES. A prospective observational study was performed adult critically ill patients who required mechanical ventilation more than 24 h. Patients were extubated after successful spontaneous breathing trial, conducted...
Abstract Background Extracorporeal membrane oxygenation (ECMO) is an integral method of life support in critically ill patients with severe cardiopulmonary failure; however, such generally require prolonged mechanical ventilation and exhibit high mortality rates. Tracheostomy commonly performed on ventilation, its early implementation has potential advantages for favorable patient outcomes. This study aimed to investigate the association between tracheostomy timing outcomes, including...
<h3>BACKGROUND:</h3> Prone positioning and neuromuscular blocking agents (NMBAs) are frequently used to treat severe respiratory failure from COVID-19 pneumonia. has shown improve mortality, whereas NMBAs prevent ventilator asynchrony reduce patient self-inflicted lung injury. However, despite the use of lung-protective strategies, high death rates in this population have been reported. <h3>METHODS:</h3> We retrospectively examined factors affecting prolonged mechanical ventilation subjects...
We assessed what predicts nutritional adequacy at day 14 following implantation of left ventricular assist device (LVAD).We retrospectively reviewed the cases 97 adult patients who underwent LVAD our institution from June 2011 to 2016. divided into two groups based on administered enteral nutrition (EN) calories post-operative (POD) 14: EN group SEN (sufficient nutrition) were >80% their total target calories, or IEN (insufficient <80% calories. compared in terms perioperative factors within...
Many patients with severe coronavirus disease 2019 (COVID-19) pneumonia experience hyperglycemia. It is often difficult to control blood glucose (BG) levels in such using standard intravenous insulin infusion therapy. Therefore, we used an artificial pancreas. This study aimed compare the BG status of pancreas that therapy.Fifteen were included study. values and speed by collected. Arterial administration rates insulin, parenteral sugar, enteral sugar recorded during The target level was 200...