A5102766717- Spinal Cord Injury Research
- Advanced Data Compression Techniques
- Spine and Intervertebral Disc Pathology
- Image and Signal Denoising Methods
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Speech Recognition and Synthesis
- Speech and Audio Processing
- Nerve Injury and Rehabilitation
- Cervical and Thoracic Myelopathy
- Emotion and Mood Recognition
- Pain Mechanisms and Treatments
- Spinal Dysraphism and Malformations
- Cytokine Signaling Pathways and Interactions
- Image Enhancement Techniques
- Anesthesia and Pain Management
- Immune Cell Function and Interaction
- Neurogenesis and neuroplasticity mechanisms
- Medical Image Segmentation Techniques
- Advanced Image Fusion Techniques
- Image and Video Stabilization
- Cardiovascular Issues in Pregnancy
- T-cell and B-cell Immunology
- Spinal Hematomas and Complications
- Macrophage Migration Inhibitory Factor
Sunagawa City Medical Center
2022
Teikyo University Chiba Medical Center
2016-2022
KDDI (Japan)
2002-2018
Chikamori Hospital
2018
KDDI Research (Japan)
2004-2018
Chiba University
2004-2017
Chiba Aoba Municipal Hospital
2013
Tokyo University of Agriculture and Technology
2012
Keio University
2011
Kyushu University
2004-2011
Suppressor of cytokine signaling 1 (SOCS1) is an important negative regulator for cytokines; however, the role SOCS1 in Th17 differentiation has not been clarified. We generated T cell-specific SOCS1-deficient mice and found that these were extremely resistant to a Th17-dependent autoimmune disease model, experimental encephalomyelitis. naive CD4(+) cells predominantly differentiated into Th1 poorly vitro. These phenotypes canceled IFN-gamma(-/-) background, suggesting large amount IFN-gamma...
Abstract Dendritic cells (DCs) induce immunity and immunological tolerance as APCs. It has been shown that DCs secreting IL-10 IL-10+ Tr1-type regulatory T (Treg) cells, whereas Foxp3-positive Treg are expanded from naive CD4+ by coculturing with mature DCs. However, the mechanism of expansion Foxp3+ not clarified. In this study, we demonstrated suppressors cytokine signaling (SOCS)-3-deficient have a strong potential cell-inducing tolerogenic SOCS3−/− expressed lower levels class II MHC,...
Osteopontin (OPN) is expressed in many tissues during inflammatory responses. After spinal cord injury, microglia expresses OPN at the site of injury early to subacute stages. However, function not well understood. This study examines responses knock-out (KO) and wild-type (WT) mice contusion injury. KO WT were injured with a modified New York University impactor. Weights 10 or 5.6 g dropped 6.25 mm onto T13 under isoflurane anesthesia. At 24 h, homogenized cords analyzed for total potassium...
Background Granulocyte colony-stimulating factor (G-CSF) is a protein that stimulates differentiation, proliferation, and survival of cells in the granulocytic lineage. Recently, neuroprotective effect G-CSF was reported model cerebral infarction we previously same studies murine spinal cord injury (SCI). The aim present study to elucidate potential therapeutic for SCI rats. Methods Adult female Sprague-Dawley rats were used study. Contusive introduced using Infinite Horizon Impactor...
We evaluated the effect of brain-derived neurotrophic factor (BDNF) on cell death after spinal cord injury. A rat injury model was produced by static load, and continuous intrathecal BDNF or vehicle infusion carried out either immediately 3 days Cell examined nuclear staining terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL). After injury, typical apoptotic cells were observed. Double with TUNEL specific markers revealed that, soon necrotic at site neurons...
Inflammation has been shown to contribute both tumor development and antitumor immunity. However, conditions determining these opposing effects are not well understood. Suppressor of cytokine signaling 1 (SOCS1) play an important role in regulating inflammation development. It reported that silencing SOCS1 gene dendritic cells potentiates immunity, while ‐deficiency whole organs except for T B enhances inflammation‐mediated colon To determine which types the suppression by ‐deficiency, we...
Object Granulocyte colony-stimulating factor (G-CSF) has neuroprotective effects on the CNS. The authors have previously demonstrated that G-CSF also exerts in experimental spinal cord injury (SCI) by enhancing migration of bone marrow–derived cells into damaged cord, increasing glial differentiation cells, antiapoptotic both neurons and oligodendrocytes, reducing demyelination expression inflammatory cytokines. Because degree angiogenesis subacute phase after SCI correlates with...
The aim of this study was to evaluate whether transplantation human bone marrow stromal cell-derived Schwann cells (hBMSC-SC) promotes functional recovery after contusive spinal cord injury adult rats. Human (hBMSC) were cultured from patients and induced into in vitro. cell phenotype confirmed by immunocytochemistry. Growth factors secreted hBMSC-SC detected using cytokine antibody array. Immunosppressed rats laminectomized their cords contused NYU impactor (10 g, 25 mm). Nine days injury,...
An open-labeled multicenter prospective nonrandomized controlled clinical trial.To confirm the feasibility of using granulocyte colony-stimulating factor (G-CSF) for treatment acute spinal cord injury (SCI).We previously reported that G-CSF promotes functional recovery after compression-induced SCI in mice. On basis these findings, we conducted a trial to assess therapy patients with SCI.The ran from August 2009 March 2011, and included 41 treated within 48 hours onset. Informed consent was...
Clinical use of autologous induced pluripotent stem cells (iPSCs) could circumvent immune rejection and bioethical issues associated with embryonic cells. Spinal cord injury (SCI) is a devastating trauma long-lasting disability, current therapeutic approaches are not satisfactory. In the present study, authors used neural sphere (NSS) method to differentiate iPSCs into astrocytes, which were evaluated after their transplantation injured rat spinal cords.Induced cell-derived astrocytes...
Abstract AgNO3 was reduced by ethylene glycol (EG) in the presence of Pt seeds and polyvinylpyrrolidone (PVP) under microwave heating. In addition to spherical nanoparticles, single-crystalline silver nano-films, rods, wires were produced. The relative number ratio nanorods nanowire total nanostructures <14%. formation mechanism anisotropic discussed.
Suppressor of cytokine signaling-1 (SOCS1) has been shown to be an essential negative regulator responses, including those IFNγ, IL-2, IL-4 and IL-7. SOCS1 deficiency resulted in hyperactivation not only T cells general but also NKT specifically. Consistent with previous reports, T- NKT-cell-specific deletion Socs1 mice enhanced sensitivity ConA-induced hepatitis. Compared wild-type (WT) cells, SOCS1-deficient produced larger quantities IFNγ response ConA proliferated faster IL-2 IL-15. To...
An open-labeled multicenter prospective controlled clinical trial.To confirm the feasibility of granulocyte colony-stimulating factor (G-CSF) administration for patients with thoracic myelopathy.Although G-CSF is best known as an important cytokine commonly used to treat neutropenia, it also has nonhematopoietic functions. Previous experimental studies have shown that can enhance tissue regeneration several organs, such heart and brain. We previously reported promotes functional recovery...
Transplantation of bone marrow stromal cells (BMSCs) for spinal cord injury (SCI) has been shown to improve functional outcome. BMSCs can be easily obtained from aspirate and have fewer problems in the clinical application human SCI ethical legal points view. Recently, we produced with neural stem and/or progenitor cell property regeneration supporting capacity (human stroma cell-derived neuroregenerative cells: hBMSC-NRs). The aim present study was clarify effectiveness transplantation...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of autoantibodies and nephritis. The [New Zealand black (NZB) × New white (NZW)]F1 (BWF1) mouse has been recognized as important animal model human SLE. Th1-prone phenotype BWF1 mice shown to contribute development lupus. However, molecular basis for Th1 skewing in not clarified. We noticed that IL-6, IL-12 other proinflammatory cytokines well IκB-ζ induction were higher mature bone marrow-derived...
Pseudoaneurysm is one of the most serious complications femoral trochanteric fracture surgery. Since rupture pseudoaneurysm may lead to death, early detection important. We report case an 80-year-old male who developed pain in proximal thigh and severe swelling after internal fixation a with hip nail. Angiography revealed branch deep artery near interlocking screw. The vascular lesion was immediately treated by transcatheter embolization, leakage completely resolved catheter embolization....
The current study is focused on automatic speech emotion recognition, and particularly the effect of additive noise reverberation recognition. emotional clean produced by four professional actors, who simulate neutral, joy, anger, sadness emotions. To produce noisy data, white Gaussian superimposed onto at several signal-to-noise ratio (SNR) levels. Concerning reverberant a technique applied which based convolution data with impulse responses recorded in environments different times....
Abstract Background Transforaminal endoscopic lumbar diskectomy (TELD) is a widely used minimally invasive surgical procedure to treat herniated disks. Postoperative dysesthesia (POD) significant complication that affects patient satisfaction. Several anatomical and magnetic resonance (MR) imaging studies of the intervertebral foramina showed TELD should be avoided in patients with small Kambin's triangular working zones. Recently, some reports indicated usefulness three-dimensional (3D)...