A5005276183- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Gut microbiota and health
- Diet and metabolism studies
- Aortic aneurysm repair treatments
- T-cell and B-cell Immunology
- Immune cells in cancer
- Protease and Inhibitor Mechanisms
- Aortic Disease and Treatment Approaches
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IL-33, ST2, and ILC Pathways
- Whipple's Disease and Interleukins
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Adipose Tissue and Metabolism
- Systemic Lupus Erythematosus Research
- Phagocytosis and Immune Regulation
- Stress Responses and Cortisol
- Cardiac Health and Mental Health
- Autophagy in Disease and Therapy
- Antioxidant Activity and Oxidative Stress
- Cardiovascular Disease and Adiposity
- Immune Cell Function and Interaction
Paris Cardiovascular Research Center
2014-2024
Université Paris Cité
2015-2024
Inserm
2015-2024
Hôpital Mustapha Pacha
2023-2024
Sorbonne Paris Cité
2016-2024
Institut National de Recherche en Santé Publique
2018-2022
Université Djilali de Sidi Bel Abbès
2018-2020
Délégation Paris 5
2010-2019
Université Côte d'Azur
2017-2018
Descartes (Belgium)
2018
In human obesity, the stroma vascular fraction (SVF) of white adipose tissue (WAT) is enriched in macrophages. These cells may contribute to low-grade inflammation and its metabolic complications. Little known about effect weight loss on macrophages genes involved macrophage attraction. We examined subcutaneous WAT (scWAT) 7 lean 17 morbidly obese subjects before 3 months after bypass surgery. Immunomorphological changes number scWAT-infiltrating were evaluated, along with concomitant...
B cell depletion significantly reduces the burden of several immune-mediated diseases. However, activation has been until now associated with a protection against atherosclerosis, suggesting that cell–depleting therapies would enhance cardiovascular risk. We unexpectedly show mature using CD20-specific monoclonal antibody induces significant reduction atherosclerosis in various mouse models disease. This treatment preserves production natural and potentially protective anti–oxidized...
Complicated abdominal aortic aneurysm (AAA) is a major cause of mortality in elderly men. Ang II–dependent TGF-β activity promotes progression experimental Marfan syndrome. However, the role models AAA has not been comprehensively assessed. Here, we show that systemic neutralization breaks resistance normocholesterolemic C57BL/6 mice to II–induced formation and markedly increases their susceptibility disease. These aneurysms displayed large spectrum complications on echography, including...
Atherosclerosis is an inflammatory vascular disease responsible for the first cause of mortality worldwide. Recent studies have clearly highlighted critical role immunoinflammatory balance in modulation development and progression. However, immunoregulatory pathways that control atherosclerosis remain largely unknown. We show loss suppressor cytokine signaling (SOCS) 3 T cells increases both interleukin (IL)-17 IL-10 production, induces antiinflammatory macrophage phenotype, leads to...
Obesity is considered a chronic low-grade inflammatory state. The white adipose tissue produces variety of inflammation-related proteins whose expression increased in obese subjects. nonadipose cell fraction, which includes infiltrated macrophages, determinant source molecules within the tissue. Our working hypothesis that macrophage infiltration affects fat expansion through paracrine action on adipocyte differentiation. Human primary preadipocytes were then differentiated presence...
Objective- Recent studies suggested the occurrence of phenotypic switching vascular smooth muscle cells (VSMCs) during development aortic aneurysm (AA). However, lineage-tracing are still lacking, and behavior VSMCs formation dissecting AA is poorly understood. Approach Results- We used multicolor lineage tracing to track their fate after injury in murine models Ang II (angiotensin II)-induced AA. also addressed direct impact autophagy on response dissection. Finally, we studied relevance...
AimInterleukin (IL)-17 pathway is being clinically targeted in immune-mediated diseases, most of which are associated with a significant cardiovascular risk. We investigated the relationship between serum levels IL-17 and risk events patients acute myocardial infarction.
Objective— Obesity is a major risk factor for atherosclerosis and associated with increased cardiovascular morbidity mortality. However, the precise molecular pathways responsible this close association remain poorly understood. Methods Results— In study, we report that leptin-deficiency ( ob/ob ) in low-density lipoprotein receptor knockout ldlr −/− mice induces an unexpected 2.2- to 6-fold reduction atherosclerotic lesion development, compared having similar total cholesterol levels. Ldlr...
Abstract Type-2 innate lymphoid cells (ILC2) are a prominent source of type II cytokines and found constitutively at mucosal surfaces in visceral adipose tissue. Despite their role limiting obesity, how ILC2s respond to high fat feeding is poorly understood, direct influence on the development atherosclerosis has not been explored. Here, we show that ILC2 present para-aortic tissue lymph nodes display an inflammatory-like phenotype atypical resident ILC2. High alters both number cytokine...
ABSTRACT The molecular mechanisms by which obesity increases the risk of cardiovascular diseases are poorly understood. purpose this study was to identify candidate biomarkers overexpressed in adipose tissue obese subjects that could link expanded fat mass atherosclerosis. We compared gene expression profile subcutaneous (scWAT) 28 and 11 lean using microarray technology. This analysis identified 240 genes significantly scWAT subjects. were then ranked according correlation between body...
We previously showed that the cysteine protease cathepsin S (CTSS), known to degrade several components of extracellular matrix (ECM), is produced by human adipose cells and increased in obesity. Because ECM remodeling a key process associated with adipogenesis, this prompted us assess potential role CTSS promote preadipocyte differentiation. Kinetic studies primary preadipocytes revealed modest increase gene expression secretion at end activity was maximal culture medium but decreased...
Current experimental models of abdominal aortic aneurysm (AAA) do not accurately reproduce the major features human AAA. We hypothesized that blockade TGFβ (transforming growth factor-β) activity-a guardian vascular integrity and immune homeostasis-would impair healing in nondissecting AAA would lead to sustained aneurysmal until rupture.Here, we test this hypothesis elastase-induced model mice. analyze development progression using ultrasound vivo, synchrotron-based ultrahigh resolution...