A5068522605- Glioma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Chromatin Remodeling and Cancer
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Meningioma and schwannoma management
- Gastrointestinal Tumor Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Soft tissue tumors and treatment
- Soft tissue tumor case studies
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- Uterine Myomas and Treatments
- Peptidase Inhibition and Analysis
- Metastasis and carcinoma case studies
- MRI in cancer diagnosis
- Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
Kagoshima University
2017-2025
Fujieda Municipal General Hospital
2024
Kagoshima University Hospital
2017-2019
Abstract Central nervous system tumors are classified based on an integrated diagnosis combining histology and molecular characteristics, including IDH1/2 H3 ‐K27M mutations, as well 1p/19q codeletion. Here, we aimed to develop assess the feasibility of a glioma‐tailored 48‐gene next‐generation sequencing (NGS) panel for glioma diagnosis. We designed NGS detecting codeletion mutations in , TP53 PTEN PDGFRA NF1 RB1 CDKN2A/B CDK4 TERT promoter ( TERTp ). analyzed 106 patients (grade II: 19...
Abstract A male in his seventies presented with lung cancer the right lower lobe. The surgically resected specimen revealed a pleomorphic carcinoma featuring an adenocarcinoma component lepidic, acinar, and papillary patterns, alongside spindle cell spreading along pulmonary artery wall, resembling intimal sarcoma. tumor cells were positive for keratins, TTF‐1, napsin A, vimentin, but negative p40, CK14, desmin, alpha‐smooth muscle actin, CDK4, MDM2. This profile indicates that originated...
Kinase-related gene fusion and point mutations play pivotal roles as drivers in cancer, necessitating optimized, targeted therapy against these alterations. The efficacy of molecularly therapeutics varies depending on the specific alteration, with great success reported for such treatment cancer kinase proteins. However, involvement actionable alterations solid tumors, especially regarding fusions, remains unclear. Therefore, this study, we aimed to compare number patients tyrosine or...
Abstract Background The treatment of hepatocellular carcinoma (HCC) requires diverse and multidisciplinary approaches. In recent years, new agents with good antitumor effects have emerged for systemic chemotherapy, conversion surgery (CS) after chemotherapy is expected to be an effective strategy unresectable HCC. We herein report a case HCC portal vein tumor thrombus (PVTT) in which atezolizumab plus bevacizumab therapy induced PVTT regression, followed by CS R0 resection. Case presentation...
Abstract Background The microbial population of the intestinal tract and its relationship to specific diseases has been extensively studied during past decade. However, reports characterizing bile microbiota are rare. This study aims investigate composition in patients with pancreaticobiliary cancers benign by 16S rRNA gene amplicon sequencing evaluate potential value as a biomarker for cancer duct, pancreas, gallbladder. Results We enrolled who were diagnosed cancer, cystic lesions,...
Rapid technological advances in molecular biology, including next-generation sequencing, have identified key genetic alterations central nervous system (CNS) tumors. Accordingly, the fifth edition of World Health Organization (WHO) CNS tumor classification was published 2021. We analyzed 303 patients with diffuse glioma using an amplicon-based glioma-tailored gene panel for detecting 1p/19q codeletion and driver mutations such as IDH1/2, TERTp, EGFR, CDKN2A/B on a single platform. Within...
Granulomatous amoebic encephalitis (GAE) is an infrequent and fatal infectious disease worldwide. Antemortem diagnosis in this condition very difficult because clinical manifestations neuroimaging are nonspecific.A 60-year-old Japanese woman was admitted with a chief complaint of left homonymous hemianopsia. Brain-MRI showed extensive necrotizing lesions enhanced by gadolinium, the right frontal lobe, occipital parietal lobe. Epithelioid granulomas unknown etiology were found biopsied brain...
Abstract Background Immune checkpoint inhibitors are reportedly effective in treating microsatellite instability (MSI)-high gastric cancer. There a few case reports of conversion surgery (CS) with nivolumab but none pembrolizumab. Herein, we describe patient MSI-high cancer who was successfully treated pembrolizumab and underwent CS pathological complete response. Case presentation A 69-year-old man diagnosed stage III (T3N2M0) based on contrast-enhanced computed tomography, which revealed...
We aimed to evaluate the mutation profile, transcriptional variants, and prognostic impact of epidermal growth factor receptor (EGFR) gene in isocitrate dehydrogenase (IDH)-wildtype glioblastomas (GBMs).We sequenced EGFR, evaluated EGFR splicing profile using a next-generation sequencing oncopanel, analyzed outcomes 138 grade IV IDH-wildtype GBM cases.EGFR mutations were observed 10% GBMs. A total 23.9% GBMs showed amplification. Moreover, 25% occurred kinase domain. Notably, alterations...
Platelet-derived growth factor receptor alpha (PDGFRA) is the second most frequently mutated tyrosine kinase in glioblastoma (GBM). However, prognostic impact of PDGFRA amplification on GBM patients remains unclear. Herein, we evaluated this by retrospectively analyzing outcomes with IDH wild-type GBM.Using a custom-made oncopanel, gain/amplification 107 samples harboring IDH, along MGMT promoter (MGMTp) methylation status.We detected 31 (29.0%). predicted poor prognosis (P = .003). Compared...
Understanding human genome alterations is necessary to optimize genome-based cancer therapeutics. However, some newly discovered mutations remain as variants of unknown significance (VUS). Here, the mutation c.1403A > G in exon 10 platelet-derived growth factor receptor-alpha (PDGFRA) gene, a VUS found adult glioblastoma multiforme (GBM), was introduced embryonal kidney 293 T (HEK293T) cells using editing investigate its potential oncogenic functions. Genome performed CRISPR/Cas9;...
Nivolumab and pembrolizumab are humanized IgG4 monoclonal antibodies against programmed cell death 1 (PD-1). Although these agents effective in treating advanced melanoma, non-small-cell lung carcinoma, other types of cancers, various adverse events have been reported. Cutaneous particularly prevalent and, while granulomatous/sarcoid-like reactions uncommon, they increasingly recognized as immune-related associated with immune checkpoint inhibitors. Herein, we report two cases reaction...
Mucins play pivotal roles in influencing cancer biology, for example affecting carcinoma invasion, aggressiveness and/or metastatic potential. Our aim is to investigate the significance of expression profiles two mucins particular, MUC1 and MUC2, their correlations with various clinicopathological features, prognosis gallbladder adenocarcinoma (GBAC). We performed immunohistochemistry from patients surgically resected GBAC, using antibodies against mucin core proteins MUC1/DF3 MUC2/Ccp58 81...
This study aimed to elucidate the impact of effective diffusion time setting on apparent coefficient (ADC)-based differentiation between primary central nervous system lymphomas (PCNSLs) and glioblastomas (GBMs) investigate usage time-dependent magnetic resonance imaging (MRI) parameters.A retrospective was conducted involving 21 patients with PCNSLs 66 GBMs using weighted (DWI) sequences oscillating gradient spin-echo (Δeff = 7.1 ms) conventional pulsed 44.5 ms). In addition ADC maps at two...
Abstract Pembrolizumab, a humanized monoclonal antibody against programmed cell death 1, is used for various malignant neoplasms. Toll‐like receptor ( TLR ) agonists, specifically targeting the 9 subfamily 7–9), are treatment options solid tumors and hematological malignancies. We experienced case of eruptive squamous carcinoma SCC in patient treated concomitantly with pembrolizumab imiquimod, 7 agonist. A 75‐year‐old woman who was given diagnosis bladder cancer lung metastasis received 3...
Abstract Background Perivascular epithelioid cell neoplasm (PEComa) in a child is very rare. We herein report the first malignant case of PEComa developing liver pediatric patient. Case presentation A 10-year-old boy visited private clinic with prolonged fever unknown etiology. Abdominal ultrasonography was performed to evaluate fever’s origin, revealing large tumor liver. He thus referred nearby hospital investigate further. Enhanced computed tomography (CT) showed 6.8 × 5.9 10.5-cm solid...
It is quite rare for breast cancer to metastasize the kidney with a tumor thrombus in inferior vena cava.A Japanese woman her forties was diagnosed of left and underwent mastectomy sentinel lymph node biopsy. The final pathological diagnosis pT1aN0M0, stage IA (ER positive, PgR HER2 negative). Thirteen years later, she presented care complaint abdominal pain. By imaging findings, right renal carcinoma cava lung metastases suspected. However, tumors were refractory molecular targeted therapy....
Abstract Background In recent years, conversion surgery after chemotherapy has been considered a promising strategy for improving the prognosis of patients with stage IV gastric cancer. However, there are few reports on gastrectomy second-line chemotherapy. Here, we report case long-term survival patient liver metastases from cancer who underwent ramucirumab and paclitaxel. Case presentation A 77-year-old man complaining weight loss was diagnosed human epidermal growth factor receptor...
POLE mutation-type endometrial cancer is characterized by an extremely high tumor mutation burden. Most cancers are histologically endometrioid carcinomas, and carcinosarcomas rare among cancers. We report a case of pelvic in 53-year-old woman who was analyzed using next-generating sequencing. The lesion harbored p.T457del with elevated burden low microsatellite instability. showed divergent histological features, consisting high-grade carcinoma, neuroendocrine chondrosarcoma. In addition to...