A5007979104- Genetic Neurodegenerative Diseases
- Infectious Diseases and Tuberculosis
- Ion channel regulation and function
- Orthopedic Surgery and Rehabilitation
- Legionella and Acanthamoeba research
- Peripheral Neuropathies and Disorders
- Vibrio bacteria research studies
- CNS Lymphoma Diagnosis and Treatment
- Whipple's Disease and Interleukins
- Multiple Sclerosis Research Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Parasitic Infections and Diagnostics
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Dermatological diseases and infestations
- Bacterial biofilms and quorum sensing
- Pharmacy and Medical Practices
- Mycobacterium research and diagnosis
- Soft tissue tumor case studies
- Prion Diseases and Protein Misfolding
- Neural dynamics and brain function
- T-cell and Retrovirus Studies
- Vestibular and auditory disorders
- Amyotrophic Lateral Sclerosis Research
- Glioma Diagnosis and Treatment
Kagoshima University
2007-2021
Kyoto University
2015
Takarazuka City Hospital
2015
Granulomatous amoebic encephalitis (GAE) is an infrequent and fatal infectious disease worldwide. Antemortem diagnosis in this condition very difficult because clinical manifestations neuroimaging are nonspecific.A 60-year-old Japanese woman was admitted with a chief complaint of left homonymous hemianopsia. Brain-MRI showed extensive necrotizing lesions enhanced by gadolinium, the right frontal lobe, occipital parietal lobe. Epithelioid granulomas unknown etiology were found biopsied brain...
Context: Toxocara canis is a parasite known to cause visceral larva migrans. The infection rarely affects the central nervous system but there have been several reports of myelitis caused by migrans due canis. In previous reported cases, lesions were located in thoracic or cervical spinal cord. To best our knowledge, this first report lesion involving lumbosacral region.Findings: A 60-year-old man developed weakness and dysesthesia lower limbs. symptoms resolved spontaneously, recurred after...
<h3>Objective:</h3> To determine the causative pathogen and investigate effective treatment of a new type encephalomyelitis with an unknown in Japan report preliminary ultrastructural genomic characterization agent. <h3>Methods:</h3> From 2005 to 2012, we treated 4 Japanese patients geographic clustering comparable clinical features, serum/CSF cytology, radiologic findings. Brain biopsy was conducted all analyze neuropathologic changes by histology, electron microscopy applied reveal...
Background and purposeGerstmann-Sträussler-Scheinker syndrome is a rare hereditary neurodegenerative disorder with clinical heterogeneity. This study aim to demonstrate the spectrum radiologic characteristics of patients caused by Pro102Leu mutation in PRNP.Materials methodsWe retrospect manifestations five from four Japanese families, comprehensively analyzed their brain MRI, SPECT (N-isopropyl-p-[123I] iodoamphetamine), PET (18F-2-fluoro-2-deoxy-d-glucose) images.ResultsAll developed...
しびれは個々でその定義が異なり，鑑別も非常に多い．高齢者においては，年齢に伴う動脈硬化性変化や骨性変化によりきたす疾患も多くみられる．診断をするにあたっては既往症や基礎疾患などの背景と伴に，発症様式，性状，部位なども重要となる．しびれのメカニズムを述べるとともに，末梢性，中枢性，部位別に分類してそれぞれの代表的な疾患の特徴や，診断をすすめるうえでの検査について述べる．
The authors describe abnormal Ga-67 and magnetic resonance imaging in a 26-year-old man with pericardial mesothelioma.
76歳，女性．進行性の認知機能障害にて発症．その後，発熱，頸部リンパ節腫脹が出現した．頸部リンパ節生検にて悪性リンパ腫と診断したが，経過中，失行，右半側空間無視，右片麻痺等の多彩な中枢神経症状を呈した．FDG-PET集積と123I-IMP SPECT血流低下部位は必ずしも一致せず，腫瘍細胞の直接浸潤や血管内リンパ腫様の虚血による病態の混在が示唆された．FDG-PETは，MRIより広範に病巣を検出し得るため，悪性リンパ腫の中枢神経系への転移病巣の把握に重要である．
The periodic paralysis (PP) and myotonic syndromes have been recognized as muscle ion channelopathies (MIC) consequent to the discovery of genetic abnormalities channels. Genetic studies are therefore indispensable in diagnosis MIC. However, it is not practical examine all channels immediately upon identification clinical symptoms. Clinical symptoms MIC occur due abnormal excitability membrane which turn related channel genes. Therefore, a series electrophysiologic tests useful examining...
痴呆性疾患の臨床診断の妥当性を明らかにするため, 痴呆患者50例について一定の基準に従って臨床診断と神経病理診断を行い, 両者を対比して, その一致・不一致について検討した.臨床診断の内訳は, アルツハイマー型痴呆 (以下ATDと略す) 14例, 脳血管性痴呆 (以下VDと略す) その他5例, 特定困難16例であった. 神経病理診断の結果はATD 16例, VD 15例, 混合型痴呆3例, その他14例, 特定困難2例であった. 今回の診断基準を適用した場合, 臨床診断と病理診断の一致率はATDよりもVDにおいて高く, 臨床診断の sensitivity はATD81.8%, VD91.7%, specificity はATD78.3%, VD86.4%であった.今回我々が用いた臨床診断基準では, 脳卒中病歴のはっきりしない緩徐進行性のVDが見逃され, 脳血管障害を合併するATDをVDと診断してしまう可能性がある. このような問題点を臨床診断にいかに反映させるかが今後の課題であると考えられた.