A5048752244- Bone and Dental Protein Studies
- Ecology and Vegetation Dynamics Studies
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Land Use and Ecosystem Services
- Forest Ecology and Biodiversity Studies
- Plant and animal studies
- Tree Root and Stability Studies
- Fire effects on ecosystems
- Forest Management and Policy
- Horticultural and Viticultural Research
- Bone Metabolism and Diseases
- Ecology and Conservation Studies
- Aeolian processes and effects
- Environmental Conservation and Management
- Coastal wetland ecosystem dynamics
- Adrenal Hormones and Disorders
- Wildlife Ecology and Conservation
- Diabetes and associated disorders
- Peatlands and Wetlands Ecology
- Isotope Analysis in Ecology
- Soil erosion and sediment transport
- Cardiovascular Function and Risk Factors
Tokushima University
2013-2023
Hokkaido University
2014-2023
Wakayama Medical University
2016-2022
Daido University
2022
Hokkaido University of Science
2022
Hokkaido University of Education
2021
Intermolecular (United States)
2014
Federico II University Hospital
2013
Flinders Medical Centre
2013
Juntendo University
2011
Osteopontin (OPN), a noncollagenous adhesive protein, is implicated in atherosclerosis, which macrophages within atherosclerotic plaques express OPN. However, it not known whether the elevated OPN expression cause or result of atherosclerosis.We generated mice that lacked and crossed them with apolipoprotein (apo) E-deficient analyzed these mixed C57BL/6x129 background after 36 weeks on normal chow diet. In female mice, OP+/-E-/- OP-/-E-/- had significantly smaller inflammatory lesions...
It has been shown that osteopontin (OPN) plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA). However, molecular mechanism OPN action is yet to be elucidated. Splenic monocytes obtained from arthritic mice exhibited significant capacity for cell migration toward thrombin-cleaved but not full-length OPN. Migratory expressed alpha9 and alpha4 integrins. Since cleavage by thrombin exposes cryptic epitope recognized integrins, we investigated SLAYGLR murine RA model using...
Osteopontin (OPN) is upregulated in several experimental models of cardiac fibrosis and remodeling. However, its direct effects remain unclear. We examined the hypothesis that OPN important for development Moreover, we whether inhibitory effect eplerenone (Ep), a novel aldosterone receptor antagonist, was mediated through inhibition expression against Wild-type (WT) OPN-deficient mice were treated with angiotensin II (Ang II) 4 weeks. WT receiving Ang divided into 2 groups: control group an...
Interleukin(IL)-17A, an inflammatory cytokine, has been implicated in atherosclerosis, which cells within atherosclerotic plaques express IL-17A. However, its role the development of atheroscelrosis remains to be controversial.To directly examine IL-17A we generated apolipoprotein E (ApoE)/IL-17A double-deficient (ApoE(-/-)IL-17A(-/-)) mice. Mice were fed with high-fat diet (HFD) for either 8 or 16 weeks, both starting at ages 6 weeks. We found that splenic CD4(+) T-cells produced high...
Syndecan-4 (Syn4), a cell-surface heparan sulfate proteoglycan, has been detected in the infarct region after myocardial infarction (MI), but its functional significance not elucidated.We examined whether and how Syn4 regulates cardiac healing process MI.Although heart Syn4-deficient (Syn4(-/-)) mice was morphologically functionally normal, Syn4(-/-) exhibited impaired function increased mortality rate as result of ruptures MI. Cardiac were associated with reduced inflammatory reaction...
Osteopontin is critically involved in rheumatoid arthritis; however, the molecular cross-talk between osteopontin and joint cell components that leads to inflammatory destruction largely unknown. We found not only but also tenascin-C their common receptor, alpha(9) integrin, are expressed at arthritic joints. The local production of mainly due synovial fibroblasts and, a lesser extent, macrophages. Synovial macrophages express autocrine paracrine interactions integrin on its ligands...
To investigate the role of osteopontin (OPN) in development osteoarthritis (OA) under vivo and vitro conditions.Both instability-induced aging-associated OA models were generated using OPN-deficient (OPN-/-) control wild-type (WT) mice. An cartilage degradation model was also used, to evaluate effect OPN on proteoglycan loss from joint cartilage.OPN deficiency exacerbated both OA. Both structural changes an increased tissue augmented absence OPN. led induction matrix metalloproteinase 13...
Abstract Human activities have had the strongest impacts on natural ecosystems since last glacial period, including alteration of interspecific relationships such as food webs. In this paper, we present a historical record major alterations trophic structure by revealing millennium-scale dietary shifts brown bears ( Ursus arctos ) Hokkaido islands, Japan, using carbon, nitrogen and sulfur stable isotope analysis. Dietary analysis revealed that salmon consumption in eastern region...
Understanding the cellular dynamics of Aire-expressing lineage(s) among medullary thymic epithelial cells (AEL-mTECs) is essential for gaining insight into roles Aire in establishment self-tolerance. In this study, we monitored maturation program AEL-mTECs by temporal lineage tracing, which bacterial artificial chromosome transgenic mice expressing tamoxifen-inducible Cre recombinase under control regulatory element were crossed with reporter strains. We estimated that half-life subsequent...
The development of UAV technologies offers practical methods to create landcover maps for monitoring and management areas affected by natural disasters such as landslides. present study aims at comparing the capability two different types deliver precise information, in order characterize vegetation landslide over a period months. For comparison, an RGB Multispectral were used identify three classes: vegetation, bare soil, dead matter, from April July 2021. results showed high overall...
Impaired production of thymic regulatory T cells (Tregs) is implicated in the development Aire-dependent autoimmunity. Because Tregs require agonistic cell receptor stimuli by self-antigens to develop, reduced expression from medullary epithelial (mTECs) has been considered play a major role Treg Aire deficiency. Here, we show that mTECs abnormally express co-inhibitory CTLA-4 if non-functional. Upon binding with CD80/CD86 ligands expressed on dendritic (DCs), ectopically Aire-deficient...
Autoimmune pancreatitis is characterized by diffuse enlargement of the pancreas, irregular narrowing pancreatic duct, high serum levels IgG4, and lymphoplasmacytic infiltration in parenchyma. Accumulating evidence suggests that this autoimmune disease could present with IgG4-positive plasmacytes multiple organs. Recently, a new concept IgG4-related systemic including pancreatitis, IgG4 level tissue plasma cells, has been proposed. Renal lesions diseases have reported recently. Most them are...
The balance between immune activation and suppression must be regulated to maintain homeostasis. Tissue macrophages (MΦs) constitute the major cellular subsets of APCs within body; however, how what types resident MΦs are involved in regulation homeostasis peripheral lymphoid tissues poorly understood. Splenic red pulp MΦ (RPMs) remove self-Ags, such as blood-borne particulates aged erythrocytes, from blood. Although many scattered T cells exist spleen, little attention has been given RPMs...
Abstract Essential roles of NF-κB–inducing kinase (NIK) for the development medullary thymic epithelial cells (mTECs) and regulatory T have been highlighted by studies using a strain mouse bearing natural mutation NIK gene (aly mice). However, exact mechanisms underlying defect in cross-talk leading to breakdown self-tolerance aly mice remain elusive. In this study, we demonstrated that production final maturation process positively selected conventional αβ are impaired mice, partly because...
ABSTRACT In recent years, we have experienced mega‐flood disasters in Japan due to climate change. the last century, been building disaster prevention infrastructure (artificial levees and dams, referred as “grey infrastructure”) protect human lives assets from floods, but these hard protective measures will not function against mega‐floods. Moreover, a drastically depopulating society such that Japan, farmland abandonment prevails, it be more difficult maintain grey with limited tax income....
High-value timber species play an important economic role in forest management. The individual tree information for such is necessary practical management and conservation purposes. Digital aerial photogrammetry derived from unmanned vehicle (UAV-DAP) can provide fine spatial spectral information, as well on the three-dimensional (3D) structure of a canopy. Light detection ranging (LiDAR) data enable area-wide 3D mapping accurate floor terrain information. In this study, we evaluated...
Abstract The interaction between matricellular proteins such as tenascin-C (TN-C) and osteopontin (OPN) integrins has been implicated in the pathology of rheumatoid arthritis which Th17 cells are recognized primary pathogenic cells. differentiation is tightly regulated by cytokines derived from APCs, receiving various signals including TLR stimuli. In this study, we used a collagen-induced model found that increased numbers α9 integrin-positive conventional dendritic macrophage were...
Abstract The risk of extreme events due to weather and climate change, such as winds unprecedented magnitude, is predicted increase throughout this century. Artificial ecosystems, coniferous plantation forests, can suffer irreversible deterioration even a slight change in environmental conditions. However, few studies have examined the effects converting natural forests plantations on their vulnerability catastrophic winds. By modelling 2004 windthrow event Typhoon Songda northern Japan...