A5101904234- interferon and immune responses
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Galectins and Cancer Biology
- Gastrointestinal Tumor Research and Treatment
- T-cell and B-cell Immunology
- Probiotics and Fermented Foods
- Viral gastroenteritis research and epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Polysaccharides and Plant Cell Walls
- Monoclonal and Polyclonal Antibodies Research
- Bone and Dental Protein Studies
- Gastric Cancer Management and Outcomes
- Inflammatory Bowel Disease
- Genetic and Kidney Cyst Diseases
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
Hokkaido University
2011-2020
Hyogo Medical University
2017-2019
Juntendo University
2003-2018
Japan Science and Technology Agency
2013
Yazaki (United States)
2012
Daido University
2006-2007
Sanford Burnham Prebys Medical Discovery Institute
2001-2004
Ureshino Medical Center
2001
The University of Tokyo
1997-1999
Osaka University
1991-1999
The interleukin-2 receptor (IL-2R) consists of three subunits: the IL-2Rα, IL-2Rβ, and IL-2Rγ chains, last which is also used in receptors for IL-4, IL-7, IL-9. Stimulation with IL-2 induces tyrosine phosphorylation activation Janus kinases Jak1 Jak3. Jak3 were found to be selectively associated "serine-rich" region IL-2Rβ carboxyl-terminal IL-2Rγ, respectively. Both regions necessary signaling. Furthermore, Jak3-negative fibroblasts expressing reconstituted IL-2R became responsive after...
Summary Lactic‐acid bacteria are widely recognized beneficial host associated groups of the microbiota humans and animals. Some lactic‐acid have ability to extend lifespan model The mechanisms behind probiotic effects not entirely understood. Recently, we reported benefit Lactobacillus gasseri SBT 2055 ( LG 2055) on animal human health, such as preventing influenza A virus, augmentation IgA production. Therefore, it was preconceived that has longevity and/or aging. We examined aging...
Abstract Lactobacillus gasseri SBT2055 (LG2055) is a probiotic lactic acid bacterium with multifunctional effects, including the prevention of influenza A virus infection in mice, reduction adipocyte size and increased lifespan C. elegans . We investigated whether LG2055 exhibits antiviral activity against respiratory syncytial (RSV), global pathogen for which preventive strategy required. Following oral administration RSV titre lung was significantly decreased, while body weight not...
Probiotic bacteria provide benefits in enhancing host immune responses and protecting against infection. Induction of IgA production by oral administration probiotic the intestine has been considered to be one reason for this beneficial effect, but mechanisms effect are poorly understood. Lactobacillus gasseri SBT2055 (LG2055) is a bacterium with properties such as bile tolerance, ability improve intestinal environment, it preventive effects related abdominal adiposity. In study, we have...
Abstract The Lactobacillus gasseri SBT2055 (LG2055) is a probiotic lactic acid bacterium with properties such as bile tolerance and ability to improve the intestinal environment. In this study, we established that oral administration of LG2055 exhibits efficacy protect mice infected influenza virus A/PR8. body weight losses were lower after PR8 infection. At 5 days infection, titer was significantly decreased amount produced IL-6 in lung tissue, number total cells bronchoalveolar lavage...
We compared the specificities and sensitivities of four tests used for serodiagnosis candidemia in 39 patients with candidemia, including 10 superficial Candida colonization, deep mycosis, 20 healthy subjects. The results obtained by dot immunoblotting assay detecting enolase antigen (48 kDa) were those assays mannan antigen, heat-labile (a threshold titer times), beta-glucan (> or = 60 pg/ml). Enolase was detected 28 (71.8%) while 30 (76.9%), (25.6%), 27 (84.4%) positive Cand-Tec assay,...
The IAN (immune-associated nucleotide-binding protein) family is a of functionally uncharacterized GTP-binding proteins expressed in vertebrate immune cells and plant during antibacterial responses. Here we show that all eight genes encoded single cluster mouse genome are predominantly lymphocytes, the expression IAN1, IAN4, IAN5 significantly elevated upon thymic selection T lymphocytes. Gain-of-function experiments premature overexpression IAN1 kills immature thymocytes, whereas short...
Type I interferons (IFNs) are known to be critical factors in the activation of host antiviral responses and also important protection from influenza A virus infection. Especially, RIG-I- IPS-1-mediated intracellular type IFN-inducing pathway is essential cells infected by virus. Previously, it has been reported that NS1 involved inhibition this pathway. We show report utilizes another inhibitory mechanism In fact, viral polymerase complex exhibited an activity on IFNβ promoter mediated...
Lactobacillus gasseri SBT2055 (LG2055) is one of the probiotic lactic acid bacteria. Recently, we demonstrated that feeding with LG2055 extended lifespan Caenorhabditis elegans and prolongevity effect was dependent upon regulation oxidative stress response. In this study, assessed whether regulated response mammalian cells. NIH-3T3 cells primary mouse embryonic fibroblast cells, low cell proliferation rates high reactive oxygen species levels were observed following paraquat treatment....
Osteopontin is critically involved in rheumatoid arthritis; however, the molecular cross-talk between osteopontin and joint cell components that leads to inflammatory destruction largely unknown. We found not only but also tenascin-C their common receptor, alpha(9) integrin, are expressed at arthritic joints. The local production of mainly due synovial fibroblasts and, a lesser extent, macrophages. Synovial macrophages express autocrine paracrine interactions integrin on its ligands...
β-(1→3)-D-glucans with β-(1→6)-glycosidic linked branches produced by mushrooms, yeast and fungi are known to be an immune activation agent, used in anti-cancer drugs or health-promoting foods. In this report, we demonstrate that oral administration of Aureobasidium pullulans-cultured fluid (AP-CF) enriched the β-(1→3),(1→6)-D-glucan exhibits efficacy protect mice infected a lethal titer A/Puerto Rico/8/34 (PR8; H1N1) strain influenza virus. The survival rate significantly increased AP-CF...
Influenza virus infection causes highly contagious, severe respiratory disorders and gives rise to thousands of deaths every year; however, the efficacy currently approved defense strategies, including vaccines neuraminidase inhibitors, is limited because frequently acquires resistance via antigen drift reassortment. It therefore important establish a novel, effective therapeutic strategy that irrespective viral subtype.Here, we identify Ras-phosphoinositide 3-kinase (PI3K) signaling pathway...
We recently reported that the intraperitoneal inoculation of Lactobacillus helveticus SBT2171 inhibited development collagen-induced arthritis (CIA), a murine model rheumatoid (RA). In present study, we evaluated effect oral administration L. on CIA and regulation antigen-specific antibody production inflammatory immune cells, which have been implicated in RA. Both reduced joint swelling, body weight loss, serum level bovine type II collagen (CII)-specific antibodies mouse model. The also...
We recently reported that Lactobacillus helveticus SBT2171 (LH2171) inhibited the proliferation and inflammatory cytokine production of primary immune cells in vitro, alleviated collagen-induced arthritis (CIA) mice, a model human rheumatoid (RA). In this study, we newly investigated whether LH2171 could relieve severity experimental autoimmune encephalomyelitis (EAE), murine multiple sclerosis (MS), which is an disease, but develop symptoms by different mechanisms from RA. MS EAE, main...
Lactobacillus helveticus SBT2171 (LH2171) is a lactic acid bacterium with high protease activity and used in starter cultures the manufacture of cheese. We recently reported that consumption cheese manufactured using LH2171 alleviated symptoms dextran sodium sulfate (DSS)-induced colitis mice. In this study, we have examined whether itself exerts an inhibitory effect on excessive proliferation lymphocytes. found inhibited LPS-stimulated mouse T B cells, human lymphoma cell lines, Jurkat...