A5024758264- Cell Adhesion Molecules Research
- Bone and Dental Protein Studies
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Bone Tissue Engineering Materials
- Advanced Nanomaterials in Catalysis
- Monoclonal and Polyclonal Antibodies Research
- Ionosphere and magnetosphere dynamics
- Immune Response and Inflammation
- Advanced Photocatalysis Techniques
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Solar and Space Plasma Dynamics
- Contact Dermatitis and Allergies
- Sphingolipid Metabolism and Signaling
- Fluid Dynamics and Turbulent Flows
- Cold Atom Physics and Bose-Einstein Condensates
- Magnetic confinement fusion research
- Angiogenesis and VEGF in Cancer
- Phagocytosis and Immune Regulation
- Erythrocyte Function and Pathophysiology
- TiO2 Photocatalysis and Solar Cells
- interferon and immune responses
Tohoku University
2017-2024
Institute of Aging
2020
Case Western Reserve University
2019
Cornell University
2019
Kyoto University
1999-2017
Hokkaido University
2007-2015
Futaba clinic
2014
Nagaoka University
2012
Juntendo University
2011
Tokyo University of Science
2011
Interleukin(IL)-17A, an inflammatory cytokine, has been implicated in atherosclerosis, which cells within atherosclerotic plaques express IL-17A. However, its role the development of atheroscelrosis remains to be controversial.To directly examine IL-17A we generated apolipoprotein E (ApoE)/IL-17A double-deficient (ApoE(-/-)IL-17A(-/-)) mice. Mice were fed with high-fat diet (HFD) for either 8 or 16 weeks, both starting at ages 6 weeks. We found that splenic CD4(+) T-cells produced high...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces severe pneumonia and is the cause of a worldwide pandemic. Coronaviruses, including SARS-CoV-2, have RNA proofreading enzymes in their genomes, resulting fewer gene mutations than other viruses. Nevertheless, variants SARS-CoV-2 exist may induce different symptoms; however, factors impacts these are not well understood. We found that there bias to occurring variants, with disproportionate mutation uracil (U)....
Osteopontin is critically involved in rheumatoid arthritis; however, the molecular cross-talk between osteopontin and joint cell components that leads to inflammatory destruction largely unknown. We found not only but also tenascin-C their common receptor, alpha(9) integrin, are expressed at arthritic joints. The local production of mainly due synovial fibroblasts and, a lesser extent, macrophages. Synovial macrophages express autocrine paracrine interactions integrin on its ligands...
The balance between immune activation and suppression must be regulated to maintain homeostasis. Tissue macrophages (MΦs) constitute the major cellular subsets of APCs within body; however, how what types resident MΦs are involved in regulation homeostasis peripheral lymphoid tissues poorly understood. Splenic red pulp MΦ (RPMs) remove self-Ags, such as blood-borne particulates aged erythrocytes, from blood. Although many scattered T cells exist spleen, little attention has been given RPMs...
Abstract The interaction between matricellular proteins such as tenascin-C (TN-C) and osteopontin (OPN) integrins has been implicated in the pathology of rheumatoid arthritis which Th17 cells are recognized primary pathogenic cells. differentiation is tightly regulated by cytokines derived from APCs, receiving various signals including TLR stimuli. In this study, we used a collagen-induced model found that increased numbers α9 integrin-positive conventional dendritic macrophage were...
Osteopontin (OPN) is a multifunctional protein that has been linked to various intractable inflammatory diseases. One way by which OPN induces inflammation the production of functional fragments enzyme cleavage. It well appreciated cleaved thrombin, and/or matrix metalloproteinase-3 and -7 (MMP-3/7). Although function thrombin-cleaved characterized, little known about MMP-3/7-cleaved OPN. In this study, we found novel motif, LRSKSRSFQVSDEQY, in C-terminal fragment mouse binds α9β1 integrin....
Sphingosine 1-phosphate (S1P) plays a role in lymphocyte egress from lymphoid organs. However, it remains unclear how S1P production and secretion are regulated. We show that under inflammatory conditions, α9 integrin, which is closely associated with activated β1 its ligand, tenascin-C, colocalize on medullary cortical sinuses of draining lymph nodes (dLNs), gate for exit, inhibition evident by blockade integrin-mediated signaling at dLNs. Based vitro analysis using lymphatic endothelial...
Abstract Disposal of apoptotic cells is important for tissue homeostasis. Defects in this process immune tissues may lead to breakdown self-tolerance against intracellular molecules, including nuclear components. Development diverse anti-nuclear Abs (ANAs) a hallmark lupus, which arise, part, due impaired cell clearance. In work, we demonstrate that spontaneous germinal centers (GCs) lupus-prone mice contain significantly elevated levels unengulfed cells, are otherwise swiftly engulfed by...
Dynamics of a point vortex in interaction with broad profile background vorticity is studied experimentally by using an electron plasma. The observed motion the compares favorably recently proposed theoretical model [D. A. Schecter and D. H. E. Dubin, Phys. Rev. Lett. 83, 2191 (1999)]. Perturbations distribution wake spiral orbit amount to several tens percent are considered be major reason for deviations observation from linear model.
Osteopontin (OPN) is an extracellular matrix protein with a wide range of functions, and involved in various inflammatory diseases. However, the role OPN eosinophilic airway inflammation unclear.To elucidate inflammation.OPN levels induced sputum from asthmatic patients healthy controls were measured. Eosinophil migration assays performed presence or absence OPN, blocking antibody (Ab) recognizing its integrin-binding domain (2K1) anti-integrin alpha 4 Ab (P1H4). In mouse asthma model,...
Objective— Syndecan-4 (Syn4) is a heparan sulfate proteoglycan and works as coreceptor for various growth factors. We examined whether Syn4 could be involved in the development of neointimal formation vivo. Methods Results— Wild-type (WT) Syn4-deficient (Syn4 −/− ) mice were subjected to wire-induced femoral artery injury. mRNA was upregulated after vascular injury WT mice. Neointimal attenuated mice, concomitantly with reduction Ki67-positive smooth muscle cells (VSMCs). Basic-fibroblast...
Osteopontin (OPN) has been implicated in various helper T cell type 1 immunity-mediated diseases including rheumatoid arthritis (RA), multiple sclerosis (MS), Crohn's disease, and fulminant hepatitis. Increased expression of OPN detected pathological foci these diseases. RA hepatitis have successfully treated by administration neutralizing anti-OPN antibody mice. Antibody treatment may elicit side effects allergic reactions against heterologous proteins, thus necessitating humanization...
Although the tumor microenvironment plays a critical role in progression and metastasis, relationship between chemotherapy resistance modulation of remains unclear. Here, we report novel mechanism showing how constitutive DNA damage signals therapy-resistant cells suppress antitumor immunity an integrin-αvβ3-dependent manner. Integrin-αvβ3 was upregulated on various through chronic activation ATM/Chk2-and NFκB-mediated pathways. Inhibiting tumor-specific expression integrin-αvβ3 improved...
Objective Syndecan 4 has been implicated as a critical mediator of inflammatory responses because its functions coreceptor and reservoir for growth factors chemokines. Although syndecan is known to be expressed on B cells, role in immune remains unclear. The purpose this study was investigate the contribution development arthritis murine models. Methods clinical severity 3 immunopathologically distinct models, collagen‐induced (CIA), antigen‐induced (AIA), collagen antibody–induced (CAIA),...
Osteopontin (Opn), a multifunctional extracellular matrix protein, is implicated in the pathogenesis of various inflammatory disorders. Under physiologic conditions, its expression restricted to certain tissues including bone and kidney tubule. However, cellular activation during disease development induces Opn immune cells. In this study, using Opn-EGFP knock-in (KI) mice we found that CD8α+ T cells intestinal tissues, Peyer's patch, lamina propria epithelium, express under steady state...
Abstract Background In systemic lupus erythematosus (SLE), autoreactive B cells are thought to develop by-passing immune checkpoints and contribute its pathogenesis. Toll-like receptor (TLR) 7 9 signaling have been implicated in their development differentiation. Although some cell subpopulations such as T-bet + double negative 2 (DN2) identified the past few years, because upregulated surface markers of those not exclusive them, it is still challenging specifically target SLE patients....
Bronchiolitis obliterans after lung transplantation is a major cause of postoperative mortality in which T cell-mediated immunity known to play an important role. However, the exact contribution natural killer (NK) cells, have functions similar CD8+ has not been defined. Here, we assessed role NK cells murine bronchiolitis through heterotopic tracheal transplantations and found greater percentage allografts than isografts. Depletion using anti-NK1.1 antibody attenuated transplant recipients...
Rutile TiO2 layers were formed on substrates of Ti-(0-10)at%Au alloys by a simple process air oxidation, and their antibacterial activities evaluated under visible-light irradiation (λ ≥ 400 nm). Au was introduced into the Ti-(1-10)at%Au existed as both metallic nanoparticles dissolved Au3+ ions. The that Ti-5at%Au Ti-10at%Au exhibited photocatalytic activity, is, degradation stearic acid activity against Escherichia coli. These attributed to surface plasmon resonance decrease in bandgap...
A vortex crystal is a quasistationary, symmetric array of intense vortices (clumps). low level background vorticity experimentally observed to assist three clumps in forming an equilateral triangle starting from initial positions on linear array. The constitutes unit cell many-vortex system. curbs the orbital motion with unequal strengths arrest them at vertices by wrapping different sized belts depleted (ring holes). We characterize contributions low-level distribution formation ordered...
While metallic biomaterials have led to an improvement in the quality of life, metal allergies, especially palladium (Pd), has caused a recent increase allergic patients. Metal allergy is known be T cell-mediated delayed-type hypersensitivity (DTH); however, pathogenic cell subsets and specific receptor (TCR) not been identified. Therefore, we attempted identify cells responsible for Pd allergy. We found that activating CD8+ significantly increased TRAV (TCRα variable) 7-2*02 chain skewed...