A5035992887- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Sarcoma Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Vascular Tumors and Angiosarcomas
- Orthopaedic implants and arthroplasty
- Lower Extremity Biomechanics and Pathologies
- Bone Tumor Diagnosis and Treatments
- Shoulder Injury and Treatment
- Tendon Structure and Treatment
- Cancer Diagnosis and Treatment
- Cardiac tumors and thrombi
- Periodontal Regeneration and Treatments
- Adhesion, Friction, and Surface Interactions
- Hip and Femur Fractures
- Orthopedic Infections and Treatments
- Tumors and Oncological Cases
- Chemokine receptors and signaling
- Musculoskeletal synovial abnormalities and treatments
- Cancer Research and Treatment
- 3D Printing in Biomedical Research
- Reconstructive Surgery and Microvascular Techniques
- Electrical Contact Performance and Analysis
- Healthcare and Venom Research
- Foot and Ankle Surgery
Hokkaido University
2018-2024
Hokkaido University Hospital
2021
Cornell University
2019
Case Western Reserve University
2019
During meniscal tissue repair, the origin of reparative cells damaged remains unclear.Comparison influence between and synovial tissues on repair by in vivo freeze-thaw method would clarify cells.Controlled laboratory study.A total 48 mature Japanese white rabbits were divided into 4 groups according to (meniscal or synovial) that received treatment. The meniscus each group had a 2 mm-diameter cylindrical defect filled with alginate gel. Macroscopic histologic evaluations performed at 1, 3,...
Abstract Background Tranexamic acid (TXA) is used as a synthetic anti-fibrinolytic agent for total knee arthroplasty (TKA) to reduce postoperative bleeding. Though the effects on bleeding reduction of several methods administering TXA have been demonstrated, optimal method remains controversial. Recently, hemostatic effect periarticular local injection during TKA was reported. Although this can be expected suppress without placing drain, its has not yet assessed in comparison with and other...
Juvenile tissue healing is capable of extensive scarless that distinct from the scar-forming process adult response. Although many growth factors can be found in juvenile process, molecular mechanisms are poorly understood. Here we show mice deficient chemokine receptor CCR7 exhibit diminished large-scale potential, whereas CCR7-depleted undergo normal similar to wild type mice. In addition, ligand CCL21 was transiently expressed around damaged cartilage mice, it rarely adults. Notably,...
Background: Many tissue-engineered methods for meniscal repair have been studied, but their utility remains unclear. Hypothesis: Implantation of low-endotoxin, ultra-purified alginate (UPAL) gel without cells could induce fibrocartilage regeneration on defects in rabbits. Study Design: Controlled laboratory study. Methods: Forty-two mature Japanese White rabbits were divided into 2 groups 21 animals each. In each animal, a cylindrical defect measuring mm diameter was created with biopsy...
As articular cartilages have rarely healed by themselves because of their characteristics avascularity and low cell density, surgical intervention is ideal for patients with cartilaginous injuries. Because structural the cartilage tissue, a three-dimensional culture stem cells in biomaterials favorable system on tissue engineering. Induced pluripotent (iPSCs) are new source engineering its self-renewal capability pluripotency. However, optimal cultivation condition chondrogenesis iPSCs still...
Brain metastasis is a rare condition among patients with soft tissue sarcoma (STS), and its precise incidence remains unclear. The aim of this study was to investigate which should be screened for brain metastasis.We identified all STS diagnosed between 2010 2015 in the SEER database. Incidence at initial presentation higher by histological subtype were investigated. In addition, risk factors examined.A total 26,676 included analysis, whom 162 (0.6%) had metastasis. Alveolar part (6.3%),...
The occurrence rate of cyclops lesion after anatomic double-bundle anterior cruciate ligament (ACL) reconstruction with remnant tissue preservation remains unclear.The study hypotheses were as follows: (1) the will be comparable between remnant-preserving and remnant-resecting ACL methods, (2) there no significant differences in clinical outcomes procedures.This retrospective comparative involved 177 patients who underwent unilateral using hamstring tendon autografts from 2014 to 2018 at our...
Background: One of the most important limitations osteochondral autograft transplantation (OAT) is adverse effect on donor sites in knee. To decrease number and/or size defects, we devised a method with biomaterial implantation after OAT. Hypothesis: OAT augmented by ultrapurified alginate (UPAL) gel enhances cartilage repair capacity. Study Design: Controlled laboratory study. Methods: Seventy-five defects rabbits were divided into 3 groups: alone, UPAL (combined group), and without...
Ultrapurified alginate (UPAL) gel implantation has been demonstrated as effective in cartilage repair for osteochondral defects; however, cell transplantation within UPAL gels would be required to treat larger defects.The combination of and bone marrow aspirate concentrate (BMAC) enhance subchondral large defects.Controlled laboratory study.A total 104 defects (1 defect per knee) 52 rabbits were randomly divided into 4 groups (26 group): without any treatment (Defect group), treated using...
Systemic injection of a nerve growth factor (NGF) antibody has been proven to have significant relevance in relieving osteoarthritis (OA) pain, while its adverse effects remain safety concern for patients. A local low-dose is thought minimize effects. In this study, OA was induced an 8-week-old male Sprague–Dawley (SD) rat joint by monoiodoacetate (MIA) 2 weeks, and the effect weekly injections (1, 10, 100 µg) NGF or saline (control) evaluated. Behavioral tests were performed, at end week 6,...
High tibial osteotomy (HTO) changes the alignment and dynamics of ankle joint; however, differences in stress distribution joint after opening-wedge HTO (OWHTO) closing-wedge (CWHTO) are not understood. It is believed that subchondral bone density articular surface reflects pattern cumulative across surface.To clarify effects OWHTO CWHTO on patterns using computed tomography (CT)-osteoabsorptiometry.Cohort study; Level evidence, 4.Radiographic CT data 18 cases who underwent (OW group), 12...
Abstract Background and Objectives Fibrosarcomas predominantly arise in soft tissues, but can also develop bone. Because of their rarity, whether bone development has an impact on clinical features not been addressed. Methods We included fibrosarcoma patients diagnosed between 1983 2016 the Surveillance, Epidemiology, End Results database. Differences (FS‐B) tissue (FS‐ST) were investigated. After excluding without information regarding cause death, site origin, distant tumor or survival,...
Primary malignant osseous neoplasms of the hand are rare malignancies. Comprehensive demographic and survival data regarding primary lacking in literature.Using Surveillance, Epidemiology, End Results (SEER) database, we identified all patients with diagnosed between 1983 2015. Demographic were searched for higher incidence histological subtype.A total 197 analyzed: 103 histologically low-grade tumor, 31 high-grade tumor. Five-year cancer-specific overall rates entire cohort 91.4% 81.9%,...
The ideal position of the femoral bone tunnel in anterior cruciate ligament (ACL) is controversial. functional importance ACL fiber varies depending on where it attached to femur. Functionally important fibers can cause high mechanical stress bone, and Wolff law predicts that mineral density will increase at sites.
Background : Periprosthetic joint infections (PJIs) following total knee arthroplasty (TKA) are among the most challenging pathologies to manage. Recently, continuous local antibiotic perfusion (CLAP) therapy has been introduced for treating musculoskeletal in orthopedics. This study aimed determine outcomes and risks of CLAP combined with conventional treatment PJIs after TKA. Methods We retrospectively evaluated 14 patients PJIs. For acute PJIs, was performed alongside debridement,...
Joint Diseases and Related Surgery (JDRS), the official journal of Turkish Foundation, is an international, peer-reviewed, immediate open access journal. All published articles in JDRS has been free for everyone, without embargo, since 1990.