BackgroundThe current surgical procedure of choice for lumbar intervertebral disc (IVD) herniation is discectomy. However, defects within IVD produced upon discectomy may impair tissue healing and predispose patients to subsequent degeneration. This study aimed investigate whether the use an acellular bioresorbable ultra-purified alginate (UPAL) gel implantation system safe effective as a reparative therapeutic strategy after discectomy.MethodsHuman cells were cultured in three-dimensional...

Although human intervertebral disc degeneration can lead to several spinal diseases, its pathogenesis remains unclear. This study aimed create a new histological classification applicable an in vivo mouse model induced by needle puncture. One hundred six mice were operated and the L4/5 was punctured with 35- or 33-gauge needle. Micro-computed tomography scanning performed, region confirmed. Evaluation performed using magnetic resonance imaging histology employing our scoring system. Our...

Subchondral bone cysts (SBCs) can significantly impact the outcomes of cartilage repair procedures such as autologous chondrocyte implantation (ACI). However, etiology and progression SBCs following ACI remain poorly understood. This case report highlights a progressively enlarging SBC using all-suture anchors, treated with osteochondral transplantation (AOT). A 58-year-old female progressive right knee pain, varus alignment, Kellgren-Lawrence grade 3 osteoarthritis underwent...

Background: Several procedures for combined rupture of both anterior cruciate ligament (ACL) and posterior (PCL) in multiple-ligament knee injuries (MLKIs) have been reported. However, the clinical outcome these treatments remains controversial. Hypothesis: Postoperative stability outcomes patients who underwent simultaneous bicruciate reconstruction would be comparable with those that collateral surgery. Study Design: Cohort study; Level evidence, 3. Methods: A retrospective study was...

Chondral delamination, characterized by separation between the articular cartilage and subchondral bone, commonly affects middle-aged adults can evolve into defects. Management of extensive chondral delamination presents a significant challenge, particularly in preserving delaminated yet structurally intact cartilage. Despite its clinical importance, there is no standardized treatment protocol for this condition, are few long-term follow-up studies surgical management. This case report...

ABSTRACT Background The integration of artificial intelligence (AI), particularly, in oncology, has significantly shifted the paradigms medical diagnostics and treatment planning. However, utility AI, specifically OpenAI's ChatGPT, soft tissue sarcoma treatment, remains unclear. Methods We evaluated ChatGPT's alignment with Japanese Orthopaedic Association (JOA) clinical practice guidelines on management tumors 2020. Twenty‐two questions (CQs) were formulated to encompass various aspects...

Abstract Approximately 40% of people under 30 and over 90% 55 or older suffer from moderate-to-severe levels degenerative intervertebral disc (IVD) disease in their lumbar spines. Surgical treatments are sometimes effective; however, the treatment back pain related to IVD degeneration is still a challenge; therefore, new necessary. Apoptosis may be important because suppressing cell apoptosis inside inhibits degeneration. Caspase-3, primary effector apoptosis, key target. We analyzed...

Abstract During progression of knee osteoarthritis (OA), gait biomechanics changes three-dimensionally; however, its characteristics and trunk posture according to OA severity remain unknown. The present study investigated three-dimensional joint severity. Overall, 75 patients (93 knees) with medial [Kellgren-Lawrence grade ≥ 2, 2: 20 24 knees (mean 60.0 years old); 3: 25 28 62.0 4: 30 41 67.9 old)] 14 healthy controls (23 knees, mean 63.6 old) underwent analysis using an optical motion...

Intervertebral disc degeneration is a significant cause of degenerative spinal diseases. Nucleus pulposus (NP) cells reportedly fail to survive in large degenerated discs with limited nutrient availability. Therefore, understanding the regulatory mechanism molecular response NP deprivation may reveal new strategy treat degeneration. This study aimed identify genes related on global scale an experimental model.Rat were subjected serum starvation. Global gene expression was profiled by...

This study analysed the outcome of 35 consecutive patients with intramedullary ependymoma who underwent a radical surgical resection between 1983 and 1996. The median age was 47 years. Tumour location cervical in 22 patients, cerviothoracic eight thoraco lumber five. proliferative activity 24 spinal 14 intracranial ependymomas were determined by MIB-1 immunolabelling. Total removal tumour achieved 26 subtotal performed nine whom six received postsurgical radiation therapy. Twenty-nine out...

A focused ion beam (FIB) system is process equipment used to make a wide variety of small structures various materials by irradiating gallium nanometer-order diameter surface specimens and utilizing spattering etching induced deposition. In order realize greater diversity with use the FIB system, we developed technology making three-dimensional using gas assist etching, precision wheel stage be in system. Using these technologies achieved nano processing machine which can called milling or lathe.

Discography and discoblock are imaging procedures used to diagnose discogenic low back pain. Although needle puncture of the intervertebral disc (IVD) itself induces degeneration, agents in these may also have harmful effects on IVD cells. The purpose this study was analyze whether radiocontrast local anesthetic detrimental human nucleus pulposus (NP) cells.Healthy NP cells were cultured for 7 days three-dimensional (3D) cell-alginate bead composites, then exposed clinically relevant doses a...

Background Analgesic discography (discoblock) can be used to diagnose or treat discogenic low back pain by injecting a small amount of local anesthetics. However, recent in vitro studies have revealed cytotoxic effects anesthetics on intervertebral disc (IVD) cells. Here we aimed investigate the deteriorative lidocaine and bupivacaine rabbit IVDs using an organotypic culture model vivo long-term follow-up model. Methods For model, were harvested cultured for 3 7 days after intradiscal...

Abstract Background Tranexamic acid (TXA) is used as a synthetic anti-fibrinolytic agent for total knee arthroplasty (TKA) to reduce postoperative bleeding. Though the effects on bleeding reduction of several methods administering TXA have been demonstrated, optimal method remains controversial. Recently, hemostatic effect periarticular local injection during TKA was reported. Although this can be expected suppress without placing drain, its has not yet assessed in comparison with and other...

Recent studies have reported that medial opening wedge (OW) high tibial osteotomy (HTO) induces patella baja, resulting in degenerative changes the patellofemoral joint. We developed an inverted V-shaped (iV) HTO, which is classified as a neutral osteotomy.The study hypotheses were follows: (1) patellar height, posterior slope, and length will not change between pre- postoperative evaluations after iV-HTO; (2) lateral shift ratio of distance tubercle trochlear groove may be significantly...

The occurrence rate of cyclops lesion after anatomic double-bundle anterior cruciate ligament (ACL) reconstruction with remnant tissue preservation remains unclear.The study hypotheses were as follows: (1) the will be comparable between remnant-preserving and remnant-resecting ACL methods, (2) there no significant differences in clinical outcomes procedures.This retrospective comparative involved 177 patients who underwent unilateral using hamstring tendon autografts from 2014 to 2018 at our...

To date, no studies have analyzed the influence on clinical outcomes of interval between an anterior cruciate ligament (ACL) injury and double-bundle (DB) reconstruction with hamstring tendon autografts.(1) Performing ACL sooner after will reduce postoperative rotatory knee instability, (2) range motion or functional results not be affected by different intervals surgery, (3) preoperative isokinetic peak torque quadriceps muscles lower in patients undergoing surgery earlier, while muscle...

Background Tenecteplase has higher fibrin specificity with a longer half-life and the potential to achieve rates of recanalization than alteplase. A critical limitation tenecteplase is no commercial use in Japan experience its administration Japanese patients. Hypothesis superior alteplase achieving on initial angiogram when administered ≤4.5-hour stroke onset patients planned for mechanical thrombectomy (MT) where at unique dose 0.6mg/kg officially used. Methods The versus For LArge Vessel...

Background: The effect of high tibial osteotomy (HTO) on the stress distribution across knee joint is not completely understood. Subchondral bone density considered to reflect pattern a surface. Purpose: To assess subchondral proximal tibia in nonarthritic knees and patients with osteoarthritis (OA) before after HTO. Study Design: Cohort study; Level evidence, 3. Methods: We retrospectively collected radiological computed tomography data from 16 without OA (control group) 17 OA. Data group...

Background: Medial open-wedge high tibial osteotomy (OWHTO) theoretically causes distalization and lateralization of the tuberosity patella. Purpose/Hypothesis: The purpose study was to identify any changes in stress distribution subchondral bone density across patellofemoral (PF) joint before after OWHTO through use computed tomography (CT) osteoabsorptiometry. We hypothesized that would alter contact PF joint. Study Design: Case series; Level evidence, 4. Methods: A total 17 patients (17...