A5030390500- Curcumin's Biomedical Applications
- Pharmacological Effects of Medicinal Plants
- Bone and Joint Diseases
- Natural product bioactivities and synthesis
- Heparin-Induced Thrombocytopenia and Thrombosis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood properties and coagulation
- DNA Repair Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Reconstructive Surgery and Microvascular Techniques
- Effects of Radiation Exposure
- Foot and Ankle Surgery
- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Carcinogens and Genotoxicity Assessment
- Reconstructive Facial Surgery Techniques
- Bone health and treatments
- Aortic Disease and Treatment Approaches
- Amino Acid Enzymes and Metabolism
- Knee injuries and reconstruction techniques
- Congenital Heart Disease Studies
- Sports injuries and prevention
- Lower Extremity Biomechanics and Pathologies
- Cancer Research and Treatments
- Cardiac Valve Diseases and Treatments
Kyoto Medical Center
2014-2022
National Hospital Organization
2001-2015
National Institutes for Quantum Science and Technology
2001
Background We previously developed a surface-controlled water-dispersible form of curcumin and named it Theracurmin® (Theracurmin; Theravalues, Tokyo, Japan). The area under the blood concentration–time curve Theracurmin in humans was 27-fold higher than that powder. determined clinical effects orally administered patients with knee osteoarthritis during 8 weeks treatment. Methods Fifty Kellgren–Lawrence grade II or III who were aged more 40 years enrolled this randomized, double-blind,...
The distribution of serum C-reactive protein (CRP) levels and their association with age, sex, atherosclerotic risk factors were studied in a large Japanese population between 1992 1995. subjects consisted 2,275 males 3,832 females aged 30 years over. CRP was measured by nephelometry. highly skewed toward lower level than that previous studies seemed to be combination two separate curves. increase age statistically significant, had higher did females. Males who current smokers nonsmokers....
A criticality accident occurred on September 30, 1999, at the uranium conversion plant in Tokai-mura (Tokai-village), Ibaraki Prefecture, Japan. When occurred, three workers saw a "blue-white glow," and radiation monitor alarm was sounded. They were severely exposed to neutron gamma-ray irradiation, subsequently developed acute syndrome (ARS). One worker reported vomiting within minutes loss of consciousness for 10-20 seconds. This also had diarrhea an hour after exposure. The other started...
We previously developed a surface-controlled water-dispersible form of curcumin that we called Theracurmin®. The area under the blood concentration-time curve (AUC) Theracurmin in humans was 27-fold higher than powder. Previously, reported on anti-inflammatory effects for knee osteoarthritis.We determined clinical orally administered patients with osteoarthritis over 6-month period.Open prospective study.Fifty Kellgren-Lawrence grade II, III, or IV who were above 40 years old enrolled this...
Aim: This study aimed to evaluate the 2-year outcomes from a clinical trial of recombinant human FGF-2 (rhFGF-2) for osteonecrosis femoral head (ONFH). Patients & methods: Sixty-four patients with nontraumatic, precollapse and large ONFHs were percutaneously administered 800 μg rhFGF-2 contained in gelatin hydrogel. Setting end point radiological collapse, we analyzed joint preservation period historical control. Changes two validated scores, bone regeneration safety evaluated. Results:...
The purpose of this study was to determine the clinical and chondroprotective efficacy safety orally administered Theracurmin in patients who underwent mosaicplasty for knee chondral or osteochondral diseases over 12 months treatment.We enrolled 50 patients, older than 20 years age, their joint diseases. at 180 mg curcumin per day placebo every months. Because 7 dropped out study, 43 were examined; they included 14 men 29 women 24 right 19 left knees. mean operative age 59.5 (range, 24-84...
Post-traumatic osteochondral defects of the distal tibial plafond may be a more common cause pain and osteoarthritis than previously recognized. However, literature on surgical treatment is significantly limited. This case report presents operative technique clinical outcome autograft transfer for an defect anterolateral surface plafond. A plugs to repair prevent progression forward displacement talus in 25-year-old man who presented with his right ankle, following history trauma.
Summary: We report a case of reconstruction left midfoot defect with chimeric partial scapula and skin flap in 20-year-old man. After radical debridement, bone soft tissue defects were reconstructed flap. The postoperative course was uneventful. patient could walk well without support, union achieved 6 months after surgery. In 14 follow-up, no clinical complications (including new ulcer or stress fracture) noted full ambulation achieved, the returning to his previous work. suggest that may...