A5101984239- Bone Metabolism and Diseases
- Inflammasome and immune disorders
- Bone health and treatments
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Gout, Hyperuricemia, Uric Acid
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiac Fibrosis and Remodeling
- Hedgehog Signaling Pathway Studies
- Mesenchymal stem cell research
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- Fibroblast Growth Factor Research
- RNA modifications and cancer
- dental development and anomalies
- Autoimmune and Inflammatory Disorders Research
- Signaling Pathways in Disease
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Oral Health Pathology and Treatment
- Microtubule and mitosis dynamics
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
Shandong University
2020-2022
Stomatology Hospital
2022
Periodontitis is a major chronic oral disease that accelerated by activation of the NLRP3 inflammasome and resulting pyroptosis. According to recent studies, active vitamin D its analogs have been reported great anti-inflammatory effects. However, mechanism newly found analog, eldecalcitol (ED-71), still unclear. This study investigates whether ED-71 could protect human gingival fibroblasts (HGFs) from LPS-induced pyroptosis and, if so, determine underlying mechanism.After HGFs were treated...
Abstract Background The incidence of diabetic osteoporosis is increasing. This article evaluates the effect combination treatment with hypoglycemic drug exendin-4 (Ex-4) and vitamin D analog eldecalcitol (ED-71) on improving explores relevant mechanism action. Method Micro-CT, HE staining, immunohistochemistry, qPCR ELISA were used to evaluate impact Ex-4 ED-71 bone formation macrophage polarization in a mouse model vivo. Immunofluorescence, flow cytometry characterize type macrophages...
Periostin is important for the maintenance of periodontal tissue, but its role in periodontitis controversial. This research investigated effect periostin and underlying mechanism.Mouse models vivo inflammation model vitro which were induced by Porphyromonas gingivalis lipopolysaccharide established to evaluate expression. Human ligament fibroblasts (PDLFs) treated with N-acetylcysteine, fluorescence staining, flow cytometry, Western blot, qRT-PCR used detect reactive oxygen species (ROS),...
Microtubules, a major target in oral squamous cell carcinoma (OSCC) chemotherapy, contribute to multiple malignant biological behaviors, including proliferation, migration, and epithelial-mesenchymal transition (EMT). Surpassing traditional tubulin inhibitors, ID09 emerges with brilliant solubility, photostability, drug-sensitivity multidrug-resistant cells. Its anti-tumor effects have been briefly verified lung adenocarcinoma hepatocellular carcinoma. However, whether OSCC is sensitive the...
Abstract Background: Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck, accounting for more than 90% oral maxillofacial malignancies. Therefore, it great importance to explore key factors regulating OSCC. Notum belongs α/β hydrolase family deacylated extracellular protein that regulates Wnt other signaling pathways. Studies have found participates in progression colorectal cancer hepatocellular targeting can regulate occurrence cancer. However, relationship...