A5051968504- Nutrition and Health in Aging
- Frailty in Older Adults
- Prostate Cancer Treatment and Research
- Kruppel-like factors research
- Bone health and osteoporosis research
- Estrogen and related hormone effects
- Ubiquitin and proteasome pathways
- 14-3-3 protein interactions
- Body Composition Measurement Techniques
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Dysphagia Assessment and Management
- interferon and immune responses
- Bone health and treatments
- Vitamin K Research Studies
- Wnt/β-catenin signaling in development and cancer
- Growth Hormone and Insulin-like Growth Factors
- Bone Metabolism and Diseases
- Radiopharmaceutical Chemistry and Applications
- Geriatric Care and Nursing Homes
- Vitamin D Research Studies
- Folate and B Vitamins Research
- Connective tissue disorders research
- COVID-19 and healthcare impacts
- RNA Research and Splicing
International University of Health and Welfare
2017-2025
Furuno (Japan)
2020-2024
Tochigi Medical Center
2024
Saitama Medical University
2003-2023
The University of Tokyo
2012-2023
Shimada Municipal Hospital
2021
Oita University
2018
Tokyo Metropolitan Institute of Gerontology
2017
University of Tokyo Hospital
2017
Nihon University
2012
Modulation of epigenetic patterns has promising efficacy for treating cancer. 5-Hydroxymethylated cytosine (5-hmC) is an mark potentially important in Here we report that 5-hmC hallmark prostate cancer (PCa) progression. A member the ten–eleven translocation (TET) proteins, which catalyse oxidation methylated (5-mC) to 5-hmC, TET2, repressed by androgens PCa. Androgen receptor (AR)-mediated induction miR-29 family, targets are markedly enhanced hormone refractory PCa (HRPC) and its high...
Abstract Background After the outbreak of coronavirus disease 2019 (COVID‐19), “pandemic‐associated‐frailty” or profound health deterioration, in older adults has been considered a concern. In this study, we sought to demonstrate whether pandemic‐associated‐frailty is occurring Japan, where population aging, by showing prevalence frailty before and during COVID‐19 outbreak, using same method. Methods A total 5222 Otawara City, Tochigi Prefecture, aged 70 75 were surveyed annually complete...
Abstract Androgen receptor (AR) is a critical transcription factor that regulates various target genes and contributes to the pathophysiology of prostate cancer hormone dependently. Here, we identify amyloid precursor protein (APP) as primary androgen through chromatin immunoprecipitation (ChIP) combined with genome tiling array analysis (ChIP-chip). ChIP-treated DNA were obtained from LNCaP cells R1881 or vehicle treatment using AR acetylated histone H3 antibodies. Ligand-dependent binding...
Wnt/β-catenin signaling is related to the pathogenesis of osteoporosis, diabetes, and metabolic diseases. Sclerostin an inhibitor signaling. However, there are few data regarding relationship between sclerostin levels disease.This study aimed identify serum levels, body composition markers, markers disease.The present a cross-sectional study. We measured in 352 Japanese postmenopausal women analyzed these with bone mineral density, abdominal fat mass, biochemical markers. The mean (sd) age...
Tripartite motif 44 ( TRIM 44) is one of the family proteins that are involved in ubiquitination and degradation target by modulating E3 ubiquitin ligases. overexpression has been observed various cancers. However, its association with testicular germ cell tumor TGCT ) unknown. We aimed to investigate clinical significance function . High expression was significantly associated α feto‐protein levels, stage, nonseminomatous NSGCT ), cancer‐specific survival P = 0.0009, 0.0035, 0.0004, 0.0140,...
// Ken-ichi Takayama 1,2 , Takashi Suzuki 3 Shuichi Tsutsumi 4 Tetsuya Fujimura 5 Tomohiko Urano Satoru Takahashi 6 Yukio Homma Hiroyuki Aburatani and Satoshi Inoue 1,2,7 1 Department of Anti-Aging Medicine, The University Tokyo, Bunkyo-ku, Japan 2 Geriatric Pathology, Tohoku Graduate School Sendai, Miyagi, Genome Science Division, Research Center for Advanced Technology (RCAST), Meguro-ku, Urology, Nihon Itabashi-ku, 7 Division Gene Regulation Signal Transduction, Genomic Saitama Medical...
Abstract The nuclear receptor ERRα (estrogen‐related α) is known to modulate the estrogen‐signaling pathway, but biological significance of in prostate remains unclear. We investigated expression human tissues and cancer cell lines evaluate potential roles (PC). Western blot analysis was performed three PC (LNCaP, DU145 PC‐3). expressions cancerous lesions ( n = 106) benign foci 99) 106 surgically obtained specimens were evaluated by immunohistochemistry. relationships between...
Abstract The androgen receptor (AR) plays a critical role in the development and progression of prostate cancer. Alterations expression AR coregulators lead to hypersensitivity, which is one mechanisms underlying cancer into castrate‐resistant state. Octamer transcription factor 1 (Oct1) ubiquitous member POU‐homeodomain family that functions as coregulator AR. In our study, contribution Oct1 was examined. Immunocytochemistry analysis showed expressed nuclei LNCaP cells. siRNA‐mediated...
Androgen receptor is an essential transcriptional factor that contributes to the development and progression of prostate cancer. In this study, we investigated androgen regulation functional analysis 14-3-3ζ in cancer.Using chromatin immunoprecipitation (ChIP) combined with DNA microarray (ChIP-chip) LNCaP cells, identified a receptor-binding site downstream region gene. was examined by quantitative reverse transcription PCR Western blot analysis. Prostate cancer cells stably expressing...
Long‐chain acyl‐coenzyme A (CoA) synthetase 3 ( ACSL ) is an androgen‐responsive gene involved in the generation of fatty acyl‐CoA esters. expressed both androgen‐sensitive and castration‐resistant prostate cancer CRPC ). However, its role remains elusive. We overexpressed androgen‐dependent LNC aP cells examined downstream effectors 3. Furthermore, we androgen metabolism cancer. overexpression led to upregulation several genes such as aldo‐keto reductase 1C3 AKR steroidogenesis, which...
The androgen receptor (AR) is the key driver of both early and advanced prostate cancer, making a complete understanding its regulation important. Here, we report identification multiple AR-binding sites in gene encoding transcription factor CtBP2 (carboxyl terminal-binding protein), genetic variations which have been associated with cancer susceptibility. Notably, found that SNPs human CTBP2 were development correlated AR-enhancer activity. High expression levels poor prognosis patients,...
The transcriptional network of the androgen receptor (AR), a key molecule prostate cancer, is frequently modulated by interactions with other factors such as forkhead box protein A1 (FOXA1). However, global regulatory mechanisms AR signaling mediated have not been well investigated. Here we conducted chromatin immunoprecipitation sequence analysis, which revealed that another FOX family, FOXP1, specifically regulated both and FOXA1. We also found FOXP1 acts tumor suppressor in cancer through...