A5025832566- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Adenosine and Purinergic Signaling
- Neurotransmitter Receptor Influence on Behavior
- Lysosomal Storage Disorders Research
- Neuroscience and Neuropharmacology Research
- Estrogen and related hormone effects
- Stress Responses and Cortisol
- Bone Metabolism and Diseases
- Nerve injury and regeneration
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Bone health and osteoporosis research
- Receptor Mechanisms and Signaling
- Genetic Neurodegenerative Diseases
- Wnt/β-catenin signaling in development and cancer
- Neurological diseases and metabolism
- Cellular transport and secretion
- Autism Spectrum Disorder Research
- Neurogenesis and neuroplasticity mechanisms
- Ginkgo biloba and Cashew Applications
- Sleep and Wakefulness Research
Tokyo Metropolitan Institute of Medical Science
2015-2025
Fuchu Hospital
2005-2011
Saitama Medical University
2002-2005
The University of Tokyo
1999-2005
Inspiration Innovation Synergy University
2004
Recently, autophagy has been associated with the TLR signaling pathway to eliminate intracellular pathogens in innate immune system. However, it is unknown if other pathways regulate during immunologic response. Given critical role of purinergic P2X7 receptor (P2X7R) various functions (i.e., caspase activation and IL-1beta secretion), principal objective here was determine whether P2X7R may cells. We observed both MG6 mouse microglial cells primary microglia that by ATP increases expression...
Parkinson's disease (PD) is a multifactorial where environmental factors act on genetically predisposed individuals. Although only 5% of PD manifestations are associated with specific mutations, majority cases idiopathic origin, environment plays prominent role. Concurrent exposure to Paraquat (PQ) and Maneb (MB) in rural workers increases the risk for adult mice MB/PQ results dopamine fiber loss decreased locomotor activity. While characterized by neuronal substantia nigra, we previously...
The discovery of α-synuclein (αS) mutations has made a major contribution to the understanding pathogenesis α-synucleinopathies such as Parkinson's disease and dementia with Lewy bodies (DLB). In contrast, less attention been paid β-synuclein (βS) mutations. this paper, we show that transgenic (tg) mice expressing DLB-linked P123H βS develop progressive neurodegeneration, characterized by axonal swelling, astrogliosis behavioural abnormalities, memory disorder being more prominent than motor...
Abstract Background Tyrosine hydroxylase (TH), an enzyme synthesizing L-dopa from tyrosine, expresses dopaminergic and noradrenergic neurons. Dopamine transporter (DAT) specifically in synaptic terminals of neurons re-uptakes extracellular dopamine. Although DAT is a specific marker, it has been suggested that express no or very slight levels (DAT-negative neurons) may also exist the midbrain. However, not known whether negative really role Aims & Objectives We generated DAT-expressing...
Abstract Background Parkinson's disease (PD) is associated with various non-motor symptoms. Among these, apathy consists of many symptoms related to emotional, self-care, and social interaction behaviors. Apathy has great impact on the lives PD patients; however, its detailed pathology remains unknown. Aims & Objectives We transversally investigated each domain apathic behaviors in mouse model 6-hydroxydopamine (6-OHDA), which induces dopamine neuronal death, an intrinsic pathological...
Neuroinflammation in Parkinson's disease (PD) is a chronic process that associated with alteration of glial cells, including astrocytes and microglia. However, the precise mechanisms remain obscure. To better understand neuroinflammation PD, we focused on activation α-synuclein (αS) transgenic related model mice. In majority αS mice, astrogliosis was observed concomitantly accumulation during early stage neurodegeneration. microglia were not extensively activated unless mice treated...
Two missense mutations (P123H and V70M) of beta-synuclein (beta-syn), the homologue alpha-syn, have been recently identified in dementia with Lewy bodies. However, mechanism through which these influence pathogenesis bodies is unclear. To investigate role beta-syn neurodegeneration, each mutant was stably transfected into B103 neuroblastoma cells. Cells overexpressing mutated had eosinophilic cytoplasmic inclusion immunopositive for beta-syn, electron microscopy revealed that cells were...
In this study we evaluate outcomes of a community-based program to prevent suicide among elderly individuals aged 65 and older.We used quasi-experimental design with intervention referent municipalities. The included 7-year implementation depression screening follow-up by general practitioners 10-year public education conducted in Yasuzuka (population 4,940; rate for women, 275/100,000; men, 323/100,000). We estimated changes the risk completing before after incidence-rate ratio (IRR).The...
The potent pro-inflammatory cytokine, interleukin-1β (IL-1β), is synthesized as an inactive 33-kDa precursor (pro-IL-1β) and processed by caspase 1 into the bioactive 17-kDa mature form. P2X7 receptor, ATP-gated cation channel, plays essential role in activation, production release of We recently reported ATP induces unconventional 20-kDa form IL-1β (p20-IL-1β) from lipopolysaccharide-primed microglial cells. Emerging evidence suggests physiological relevance for p20-IL-1β; however,...
Dopaminergic systems have been known to be involved in the regulation of locomotor activity and development psychosis. However, observations that some Parkinson's disease patients can move effectively under appropriate conditions despite low dopamine levels (eg, kinesia paradoxia) several psychotic symptoms are typical antipsychotic resistant atypical sensitive indicate other beyond dopaminergic system may also affect The present study showed dopamine-deficient (DD) mice, which had received...