A5037522884- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- CNS Lymphoma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Single-cell and spatial transcriptomics
- Vascular Malformations Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Mathematical Biology Tumor Growth
- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Facial Trauma and Fracture Management
- Neurogenesis and neuroplasticity mechanisms
- Lymphoma Diagnosis and Treatment
- Virus-based gene therapy research
- Cancer Cells and Metastasis
Nagoya University
2016-2025
Shizuoka Cancer Center
2024-2025
Nagoya University Hospital
2020-2024
Daido University
2024
Tokyo Metropolitan University
2024
Tokatsu Hospital
2022
Aichi University
2016
Nagoya City University
2015
Graduate School USA
2015
Centre International de Recherche sur le Cancer
2012-2013
Diffuse lower-grade gliomas (LGGs) are genetically classified into 3 distinct subtypes based on isocitrate dehydrogenase (IDH) mutation status and codeletion of chromosome 1p 19q (1p/19q). However, the subtype-specific effects additional genetic lesions survival largely unknown.Using Cox proportional hazards regression modeling, we investigated alterations clinicopathological factors in each LGG subtype, a Japanese cohort cases fully genotyped for driver mutations copy number variations...
Isocitrate dehydrogenase 1 (IDH1), which localizes to the cytosol and peroxisomes, catalyzes oxidative decarboxylation of isocitrate α-ketoglutarate (α-KG) in parallel converts NADP+ NADPH. IDH1 mutations are frequently detected grades 2–4 gliomas acute myeloid leukemias (AML). Mutations have been identified at codon 132, with arginine being replaced histidine most cases. Mutant gains novel enzyme activity converting α-KG d-2-hydroxyglutarate (2-HG) acts as a competitive inhibitor α-KG. As...
Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor in adults with a 5-year overall survival rate of less than 10%. Podoplanin (PDPN) type I transmembrane mucin-like glycoprotein, expressed lymphatic endothelium. Several solid tumors overexpress PDPN, including mesenchymal GBM, which has been reported to present worst prognosis among GBM subtypes. Chimeric antigen receptor (CAR)-transduced T cells can recognize predefined surface antigens independent MHC...
The deep frontal pathway connecting the superior gyrus to Broca's area, recently named aslant tract (FAT), is assumed be associated with language functions, especially speech initiation and spontaneity. Injury lobe known cause aphasia that mimics caused by damage supplementary motor area. Although fiber dissection tractography have revealed existence of tract, little about its function. aim this study was determine function FAT via electrical stimulation in patients glioma who underwent...
Abstract Background Approximately 70% of lower-grade gliomas harbor isocitrate dehydrogenase 1 (IDH1) mutations, resulting in the accumulation oncometabolite D-2-hydroxyglutarate (D-2-HG); this leads to epigenetic dysregulation, oncogenesis, and subsequent clonal expansion. DS-1001 is an oral brain-penetrant mutant IDH1 selective inhibitor. This first-in-human study investigated safety, pharmacokinetics, pharmacodynamics, efficacy DS-1001. Methods was a multicenter, open-label,...
Gliomas are the most frequently occurring primary brain tumor in central nervous system of adults. Glioblastoma multiformes (GBMs, WHO grade 4) have a dismal prognosis despite use alkylating agent, temozolomide (TMZ), and even low gliomas (LGGs, 2) eventually transform to malignant secondary GBMs. Although GBM patients benefit from promoter hypermethylation O(6)-methylguanine-DNA methyltransferase (MGMT) that is main determinant resistance TMZ, recent studies suggested MGMT methylation...
The aim of the current study was to catalog genomic and epigenomic abnormalities in newly diagnosed glioblastoma patients determine correlation among clinical, genetic, epigenetic profiles clinical outcome.This retrospectively included 68 consecutive who underwent surgical treatment received standard radiotherapy with temozolomide (TMZ)-based chemotherapy. Of a total patients, 39 (57.4%) interferon (IFN)-β combination TMZ.The genetic alterations frequently observed were EGFR amplification...
In this study, we investigated changes in resting state networks (RSNs) patients with gliomas located the left hemisphere and its relation to cognitive function. We hypothesized that long distance connection, especially between hemispheres, would be affected by presence of tumor. further these correlate with, or reflect observed gliomas. Resting functional MRI datasets from 12 healthy controls were used analysis. The tumor's effect on three well-known RSNs including default mode network...
There are no accurate mass screening methods for early detection of central nervous system (CNS) tumors. Recently, liquid biopsy has received a lot attention less-invasive cancer screening. Unlike other cancers, CNS tumors require efforts to find biomarkers due the blood–brain barrier, which restricts molecular exchange between parenchyma and blood. Additionally, because satisfactory way collect urinary is lacking, urine-based not been fully investigated despite fact that it some advantages...
Alexia and agraphia are disorders common to the left inferior parietal lobule, including angular supramarginal gyri. However, it is still unclear how these cortical regions interact with other sites what most important white matter tracts in relation reading writing processes. Here, authors present case of a patient who underwent an awake craniotomy for lobule glioma using direct subcortical electrostimulation. The use stimulation allowed identification specific associated writing. These...
OBJECTIVE Maximum extent of resection (EOR) for lower-grade and high-grade gliomas can increase survival rates patients. However, these infiltrative are often observed near or within eloquent regions the brain. Awake surgery is known benefit treatment associated with in that brain function be preserved. On other hand, intraoperative MRI (iMRI) has been successfully used to maximize tumors, which detect small amounts residual tumors. Therefore, authors assessed value combining awake...
OBJECTIVE Lower-grade gliomas (LGGs) are often observed within eloquent regions, which indicates that tumor resection in these areas carries a potential risk for neurological disturbances, such as motor deficit, language disorder, and/or neurocognitive impairments. Some patients with frontal tumors exhibit severe impairments of function, including working memory and spatial awareness, after removal. The aim this study was to investigate functional outcomes LGGs both the dominant nondominant...
Abstract Background Recent comprehensive studies have revealed several molecular alterations that are frequently found in meningiomas. However, effective treatment reagents targeting specific not yet been identified because of the limited number representative research models Methods We performed organoid cultures using meningioma cells and tumor tissues. Using immunohistochemistry analyses consisting whole-exome sequencing, RNA-seq, DNA methylation analyses, we compared histological...
Diffuse hemispheric glioma H3 G34-mutant (DHG) has been identified as a distinct pediatric-type high-grade glioma, according to the World Health Organization (WHO) classification of central nervous system tumors. Widely accepted treatment options include surgery, radiation, and conventional chemotherapy. However, efficacy surgical resection remains unclear. Although there are some reports, comprehensive understanding clinical characteristics, pathogenesis, outcomes DHG is insufficient...
The isotype of epidermal growth factor receptor variant III (EGFRvIII) is often identified in glioblastomas. Previously, we created a mouse monoclonal antibody, 3C10 (IgG2b), that specifically recognized EGFRvIII, and recombinant single‐chain variable fragment 3C10. aim the current study was to develop genetically engineered T cells, termed T‐bodies, express chimeric consisting coupled signaling modules such as CD3zeta (ζ) chain, for treatment tumors expressing mutant EGFR. After successful...