A5070308574- Glioma Diagnosis and Treatment
- earthquake and tectonic studies
- Virus-based gene therapy research
- Cancer-related Molecular Pathways
- Geological and Geochemical Analysis
- Speech and Audio Processing
- Radiomics and Machine Learning in Medical Imaging
- Chronic Lymphocytic Leukemia Research
- Metal and Thin Film Mechanics
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Advanced ceramic materials synthesis
- Epigenetics and DNA Methylation
- Pituitary Gland Disorders and Treatments
- Ocular Oncology and Treatments
- Hemoglobin structure and function
- Management of metastatic bone disease
- Meningioma and schwannoma management
- Barrier Structure and Function Studies
- Nanoplatforms for cancer theranostics
- Blind Source Separation Techniques
- Heme Oxygenase-1 and Carbon Monoxide
- Clay minerals and soil interactions
- MicroRNA in disease regulation
- Synthesis and properties of polymers
Nagoya University
1983-2025
National Institute of Advanced Industrial Science and Technology
2006-2021
Sanno Medical Center
2019
University of Tsukuba
2011
Diffuse hemispheric glioma H3 G34-mutant (DHG) has been identified as a distinct pediatric-type high-grade glioma, according to the World Health Organization (WHO) classification of central nervous system tumors. Widely accepted treatment options include surgery, radiation, and conventional chemotherapy. However, efficacy surgical resection remains unclear. Although there are some reports, comprehensive understanding clinical characteristics, pathogenesis, outcomes DHG is insufficient...
Aluminum nitride (AlN) usually exhibits a microstructure consisting of equiaxed grains. However, these grains do not allow for the positive control and mechanical properties AlN. In this work, we attempted to AlN through addition whiskers investigated relationship between properties. The sintered showed large, rod-like grains, which originated from whiskers. Furthermore, varied with size amount added, so did flexural strength fracture toughness. toughness whisker-added samples ranged 197 267...
Li-Fraumeni syndrome (LFS) is an autosomal dominant tumor predisposition caused by heterozygous germline mutations or deletions in the TP53 suppressor gene. Central nervous system tumors, such as choroid plexus medulloblastomas, and diffuse gliomas, are frequently found patients with LFS. Although molecular profiles of gliomas that develop pediatric LFS have been elucidated, those adults limited. Recently, divided into pediatric- adult-type based on their distinct profiles. In present study,...
Abstract Patients with diffuse frontal gliomas often present post‐operative apathy after tumour removal. However, the association between and removal of from lobe remains unknown. This study aimed to investigate factors influencing in patients gliomas. We compared demographics clinical characteristics without a cohort 54 who underwent awake brain mapping for The frequency parameters such as left‐sided involvement, high‐grade types (WHO grades III, IV), main location anterior cingulate gyrus...
Abstract Pancreatic stellate cells (PSCs) are stromal in the pancreas that play an important role pancreatic pathology. In chronic pancreatitis (CP) and ductal adenocarcinoma (PDAC), PSCs known to get activated form myofibroblasts or cancer‐associated fibroblasts (CAFs) promote fibroinflammatory reactions. However, previous studies on were mainly based findings obtained using ex vivo expanded PSCs, with few addressed significance of situ tissue‐resident animal models. Their contributions...
History effects of prior creep on subsequent plasticity were studied for type 316 stainless steel at 600°C under combined torsion and tension. Following each three different amounts torsional creep, plastic deformation tests performed torsions in the same opposite directions axial tension, respectively. The experimental results showed marked influence plasticity. That is, flow stress after became larger than one corresponding pure test where strain creep-plasticity was replaced by a amount....
Mutations in the isocitrate dehydrogenase (IDH) gene are recognized as key drivers oncogenesis of astrocytoma and oligodendroglioma. However, significance IDH mutation tumor maintenance malignant transformation has not been elucidated. We encountered a unique case IDH-mutant that, upon transformation, presented two distinct intratumoral components: one IDH-wildtype IDH-mutant. The IDH-wild-type component exhibited histological findings similar to those small cell-type glioblastoma with...
Abstract Genetic abnormalities such as IDH, TERT promoter, and CDKN2A play a critical role in diagnosing adult-type diffuse gliomas. Intraoperative genetic diagnosis offers strategic advantage by informing surgical decisions based on accurate information. Recent findings suggest that the presence or absence of these molecular could differentiate tumor cells from normal brain tissue, potentially guiding intraoperative margin assessments where boundary with tissue is unclear. This study...
Abstract Pituitary neuroendocrine tumors (PitNETs) are that originate from the anterior pituitary gland. While they mostly benign, can cause various clinical symptoms due to hormonal secretion abnormalities. PitNET be broadly categorized into three lineages, each of which has its differentiation controlled by specific transcription factors. Treatment options for include surgical resection and pharmacotherapy, but available drugs limited, their efficacy markers remain unclear. To develop...
Abstract BACKGROUND Diffuse hemispheric gliomas, H3 G34-mutant (DHGs-G34m) are newly recognized pediatric-type diffuse high-grade gliomas. We describe detail imaging features of seven cases DHGs-G34m and consider about progression pattern DHGs-G34m. RESULTS G34R or G34V was detected by sanger sequencing in all tumors. Mean age onset 16.5 years (range: 10-26). Tumors were located on frontal (2), parietal temporal lobe (1) insular cortex (1), respectively. In one case, gliomatosis cerebri-like...
Abstract BACKGROUND Diffuse hemispheric gliomas, H3 G34-mutant (DHG-G34m) are newly recognized pediatric-type diffuse high-grade gliomas. We describe detail imaging features of seven cases DHG-G34m and consider about progression pattern DHG-G34m. RESULTS G34R/V was detected by sanger sequencing in all tumors. Mean age onset 16.5 years (range: 10-26). Tumors were located on frontal (n=2), parietal temporal lobe (n=1) insular cortex (n=1), respectively. In one case, gliomatosis cerebri-like...
Aluminum nitride (AlN) possesses excellent thermal conductivity and electrical resistivity, which makes it an ideal candidate for high-power, high-speed integrated circuit substrates. Its low fracture toughness requires the manufacturing of thicker However, this leads to degraded heat dissipation performance. Herein, we investigated a new strategy, combining addition AlN whiskers tape-casting, overcome disadvantage. The sintered with induced formation highly anisotropic microstructure...
症例は 50 歳，女性。左下腿の虫刺様皮疹に対し市販外用薬を塗布していたが，同部が潰瘍を伴う隆起性病変となったため，1 カ月後，当科を受診した。初診時，左下腿内側に径 3 cm の黄色痂皮が付着した隆起性潰瘍病変を認め，ヨードコート®軟膏外用を開始したが悪化したため，壊疽性膿皮症などを疑った。血液検査で血清クロール濃度(Cl)が 156 mEq/l(正常：98∼108 mEq/l)と異常高値であったが，4 年前から高 Cl 血症であったことが判明した。詳細な問診の結果，約 10 年間，慢性頭痛に対してブロモバレリル尿素含有の市販鎮痛薬(ナロン®顆粒)を内服していることが判明した。臭素摂取過量による偽性高 血症を呈したと考え，血中臭素濃度を測定したところ 500 mg/l(正常 5 mg/l 以下)と中毒域であった。皮疹辺縁部の皮膚生検では表皮は偽癌性増殖を呈し，真皮内には膿瘍形成を認め，臭素疹と確定診断した。 その後，ナロン®顆粒の内服を中止したところ速やかに は正常化し，皮疹も色素沈着となり軽快した。...
Abstract BACKGROUND Growth hormone-producing pituitary adenomas (GHomas) reveal unfavorable clinical course due to systemic complications such as excessive sweating, impaired glucose tolerance, and hypertension, in addition its characteristic facial appearance. For GHoma, pharmacological treatments including somatostatin analogs dopamine agonists are widely performed, however, a subset of case reveals dismal prognosis. We need elucidate molecular mechanisms contributing GHoma growth,...
Abstract Recent comprehensive molecular analyses of central nervous system (CNS) tumors identified several diagnostic or prognostic markers. IDH mutation, TERT promoter (pTERT) mutation and CDKN2A homozygous deletion in adult-type diffuse gliomas, BRAF p.V600E circumscribed astrocytic histone H3 gene mutations pediatric-type high-grade gliomas MYD88 primary CNS lymphoma (PCNSL) are quite important Intra-operative identification these alterations could be effective for decision-making tumor...
Abstract Molecular alterations that predict aggressive behavior of astrocytic tumors include EGFR amplification, TERT promoter (pTERT) mutations, gain chromosome 7 and loss 10. During January 2020 February 2023, we encountered 21 cases pathologically diagnosed glioblastoma, IDH-wildtype without the above-mentioned molecular characteristics. In this study, tried to characterize these tumors. For all cases, genomic DNA was extracted from fresh frozen tissue. Using DNA, analyze status IDH...
Abstract In recent years, R-MPV therapy has been widely used for treatment of primary central nervous system lymphoma (PCNSL). Although a high response rate and favorable prognosis have reported with using multiple drugs, the strategy cases refractory to induction not established. High-dose radiotherapy is currently recommended cases, however, efficacy frequency adverse events such as leukoencephalopathy are yet clear. Tirabrutinib available recurrent or PCNSL since 2020. However, there few...
Abstract OBJECTIVE Tumor-Treating Fields therapy has been the standard for newly diagnosed glioblastoma since 2018 in Japan. The patients are recommended to use system 18 or more hours per day. In practice, some could not it long-term and dropped out from this therapy. We examined factors related interruption of NovoTTF use. METHODS reviewed clinical course NovoTTF-100A (NovoTTF) cases at our hospital April May 2023. compared group that continued used until disease progressed (Group A) with...
Abstract The WHO Classification the 5th edition describes that identification of alterations in IDH gene, histone H3 CDKN2A and other genes are quite important for diagnosis grading diffuse gliomas. It is to efficiently analyze genetic abnormalities utilize them actual clinical practice. In our institute, we have recently performed analysis which glioma all patients. Here, report results these analyses. From March 2019 June 2023, Sanger sequencing analyses IDH1/2, H3F3A, TERT promoter, BRAF,...
Abstract A performance evaluation of frequency‐domain blind source separation (BSS) in a close arrangement directional microphone is carried out. When used time‐domain BSS, it possible to reduce the number taps necessary for while maintaining same as without arrangement. In this research, from point view relationship between and performance, calculation time, permutation (output order) unique frequency domain comparison with nonclose made. With regard time error, superior environments both...