A5103073747- T-cell and Retrovirus Studies
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Animal Disease Management and Epidemiology
- Acute Ischemic Stroke Management
- T-cell and B-cell Immunology
- Cerebrovascular and Carotid Artery Diseases
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Genetic Neurodegenerative Diseases
- Immunotherapy and Immune Responses
- Pain Management and Treatment
- Neurological disorders and treatments
- Eicosanoids and Hypertension Pharmacology
- Restless Legs Syndrome Research
- Spinal Dysraphism and Malformations
- Intraoperative Neuromonitoring and Anesthetic Effects
- Immune Cell Function and Interaction
- Parkinson's Disease Mechanisms and Treatments
- RNA regulation and disease
- Analytical Chemistry and Chromatography
- Vector-Borne Animal Diseases
- Cholesterol and Lipid Metabolism
- RNA and protein synthesis mechanisms
- Hereditary Neurological Disorders
Imari Arita Kyoritsu Hospital
2013-2024
Meiji (Japan)
2024
International University of Health and Welfare
2022-2024
Shirasagi Hospital
2024
Stony Brook University
2022
Neurological Surgery
2022
Japan Food Research Laboratories
2001-2017
Shiga Medical Center for Adults
2017
Mimasaka University
2012
Toyooka Hospital
2012
In neuromyelitis optica (NMO), B-cell autoimmunity to aquaporin-4 (AQP4) has been shown be essential. However, the role of T cells remains ambiguous. Here, we first showed an increase in CD69+ activated PBMCs during NMO relapses. Next, T-cell responses AQP4 and myelin peptides were studied 12 NM0 patients, 10 multiple sclerosis (MS) patients healthy subjects (HS). Four hours after adding 1 28 overlapping peptides, a mixture (AQP4-M) or one six distinct 2-day cultured PBMC, CD69 expression on...
Five endocrine disrupting chemicals were degraded enzymatically in model bottom sediments. Since alkylphenols, bisphenol A, synthetic estrogen and phthalic esters are hydrophobic found to be sediments the water environment, we used a polluted sediment which those adsorbed on sea sand. The concentration of alkylphenols (nonylphenol octylphenol) (ethynylestradiol) decreased by fungal laccases oxidize phenols with aid molecular oxygen. Bisphenol A was laccase from basidiomycetes extracellular...
Abstract: Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type‐1/T type‐2 (Th1/Th2) cytokine‐producing‐cell balance in 3 patients with neuroimmunological disease. The production of interferon‐γ (IFN‐γ), interleukin‐2 (IL‐2), and IL‐4 the culture supernatant peripheral blood mononuclear cells stimulated by anti‐CD3 anti‐CD28 was assayed. In 2 patients, (immunoadsorption or plasma exchange)...
We report of a woman aged 52 years born to consanguineous parents and seeking treatment for progressive dementia delusion. Neurologic examination revealed emotional instability, indifference, confabulation. There was also mild spasticity the bilateral lower limbs. MRI diffuse white matter hyperintensity on T2-weighted images accompanied by hypointense areas fluid-attenuated inversion recovery images. A homozygous missense mutation identified in EIF2B5.
Background : It has become increasingly clear that polyunsaturated fatty acids (PUFAs) have immunomodulatory effects. However, the intake of these used in animal studies often greatly exceeds dietary human intake. Whether differences composition are consumed amounts consistent with normal can influence immune function remains uncertain. Methods We manufactured 3 types liquid diet, related to modified acid (ω‐6/ω‐3 = 0.25, 2.27 and 42.9), but excluding eicosapentaenoic docosahexaenoic acid,...
The first choice to treat acute subdural hematoma (ASDH) is large craniotomy under general anesthesia. However, increasing age or the comorbid burden of patients may render invasive treatment strategy inappropriate. These medically frail with ASDH benefit from a combination small and endoscopic removal, which less invasive. We proposed covering protective sheets prevent brain injury due contact endoscope suction cannula improve visualization space. Moreover, we placed an intracranial...
Abstract Oral tolerance is systemic immune hyporesponsiveness induced by the oral administration of soluble Ags. Hyporesponsiveness Ag-specific CD4 T cells responsible for this phenomenon. However, molecular mechanisms underlying hyporesponsive state these are not fully understood. In present study, we investigated ability orally tolerized to form conjugates with Ag-bearing APCs and translocate TCR, protein kinase C-θ (PKC-θ), lipid rafts into interface between APCs. Orally were prepared...
We investigated the production of inflammatory cytokines derived from cultured T cells peripheral blood lymphocytes (PBL) in 14 patients with HTLV-I-associated myelopathy (HAM). The cytokines, such as tumor necrosis factor-alpha, interferon-gamma, and granulocyte-macrophage colony stimulating factor, was significantly increased HAM, compared to HTLV-I seronegative controls. On contrary, interleukin-4 detected only two not These results suggest that TH1 cell population simultaneously...
The histological features of cortical tubers in patients with tuberous sclerosis (TS) were studied by the proton magnetic resonance spectroscopy (MRS).The subjects 4 children, mean age 10 years, clear evidence on MRI and SPECT. Four age-matched control children served as subjects. Spectra acquired over tuber using short TE.The myoinositol/creatine ratios TS significantly increased compared those (P < 0.02). NAA/creatine decreased 0.02).The decrease was considered to reflect a reduction...
Abstract: Treatment for Miller Fisher syndrome (MFS) is controversial, and even the natural history prognosis are not fully understood. We retrospectively reviewed our cases of MFS last 3 years. The analysis 4 revealed that we had performed plasmapheresis or additional immunotherapy to each patients, their symptoms resolved up 50 days after onset (ataxia improved 20–35 ophthalmoplegia 25–50 days) except 1 patient, Guillain‐Barré been diagnosed in patient who developed profound muscle...
We developed a determination method for sphingoid bases using online post-column high-performance liquid chromatography (HPLC) with O-phthalaldehyde (OPA) derivatization. Good separation was achieved reversed-phase column and eluting 50% acetonitrile containing formic acid heptafluorobutyric acid. Using these conditions, an excellent linearity (R² > 0.999) standard solutions of sphinganine (d18:0), sphingosine (d18:1(4t)), 4-hydroxy-sphinganine (t18:0), glucosylsphingosine (glc-d18:1(4t)),...
We developed a novel pre-separation method of trans fatty acids (TFAs) using silver-ion cartridge column and GC. As preliminary study, mixture acid methyl esters consisting saturated, cis-unsaturated, trans-unsaturated was dissolved in dichloromethane loaded onto Bond Elut SCX ion-exchange that converted to the form. The then eluted with obtain saturated acids, dichloromethane/ethyl acetate (90/10) for mono-ene, (65/35) cis dichloromethane/acetone (60/40) di-ene, acetone/acetonitrile (80/20)...
A 56-year-old man was admitted to our hospital with episodic visual hallucinations in the left field.On neurological examination, hemianopia found.Blood glu-cose 677 mg/dL, serum osmolality 310.6 mOsmol/ L, and urine ketone negative.FLAIR T2-weighted brain MRI demonstrated hyperintense lesions cortical
Creutzfeldt-Jakob disease (CJD) is a subacute spongiform encephalopathy characterized clinically by progressive dementia with myoclonus and extrapyramidal symptoms. If no characteristic EEG findings are found, clinical diagnosis difficult. CT of little use. MRI has been reported both to be value1 helpful in the CJD.2-4 A few CJD patients point mutation at codon 232 prion protein gene have reported.5-7 We describe changes cerebral cortex patient 232. Case report. 64-year-old woman who had...
We previously reported increased adherence of T cells to human endothelial (EC) in patients with HTLV-I-associated myelopathy (HAM). To define the immunological function EC-adherent from HAM patients, we investigated degree spontaneous proliferation and production inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) granulocyte-macrophage colony stimulating factor (GM-CSF). Both TNF-α, IFN-γ GM-CSF by were significantly increased, compared anti-HTLV-I...
Monoacylglycerol (MAG) and diacylglycerol (DAG) are minor components of edible fats oils, they relate to the quality these foods. The AOCS official method Cd 11b-91 has been used determine MAG DAG contents in oils. There are, however, difficulties determination using this analytical procedure. Therefore, we improved by modifying trimethylsilyl derivatization procedure replacing internal standard (IS) material. In our modified method, TMS-HT (mixture hexamethyldisilazane...