A5034351457- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Bone and Joint Diseases
- Hepatitis C virus research
- NF-κB Signaling Pathways
- Hepatitis B Virus Studies
- Foot and Ankle Surgery
- Cytokine Signaling Pathways and Interactions
- Musculoskeletal synovial abnormalities and treatments
- T-cell and Retrovirus Studies
- Liver Disease Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Herpesvirus Infections and Treatments
- Orthopedic Surgery and Rehabilitation
- interferon and immune responses
- Infectious Diseases and Tuberculosis
- Toxin Mechanisms and Immunotoxins
- HER2/EGFR in Cancer Research
- Autoimmune and Inflammatory Disorders Research
- IgG4-Related and Inflammatory Diseases
- Potassium and Related Disorders
- Neuroendocrine Tumor Research Advances
- Vasculitis and related conditions
Akashi Medical Center
2025
Medical Center Hospital
2025
Matsuyama Red Cross Hospital
2015-2024
Ehime University
1999-2010
Although the reactivation of hepatitis B virus (HBV) is recognised as a serious complication in patients with rheumatic disease (RD) receiving immunosuppressive drugs (ISDs), incidence and risk factors for remain controversial.To investigate HBV RD.We performed multicentre, observational, prospective study over 2 years resolved infection. Patients RD treated dose ≥5 mg/day prednisolone and/or synthetic or biological ISDs negative HB surface antigen positive anti-HB antibody (HBsAb) core...
A 71-year-old woman with previously undiagnosed human T-lymphotropic virus type 1 (HTLV-1) infection presented fever, urinary difficulties, acute abdominal pain, and severe kidney injury (AKI). Diagnostic evaluations confirmed pyelonephritis (APN) focal bacterial nephritis (AFBN). Despite antibiotic treatment, she required temporary hemodialysis eventually developed chronic disease. This case highlights the importance of considering APN AFBN as differential diagnoses in patients presenting...
Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation with aberrant epigenetic alterations, eventually leading to joint destruction. However, the regulatory mechanisms underlying RA pathogenesis remain largely unknown. Here, we showed that ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) a central regulator orchestrates multiple pathogeneses in suppressive manner. UHRF1 expression was remarkably upregulated fibroblasts (SFs) from model mice patients RA....
Abstract Objective To clarify the mode of inheritance and genome origins arthritis in a lupus‐prone strain mice, MRL/MpJ, bearing Fas deletion mutant gene, lpr (MRL/lpr). Methods Using non–lupus‐prone strains C3H/HeJ‐ lpr/lpr (C3H/lpr), (MRL/lpr × C3H/lpr)F 1 intercross MRL/lpr backcross mice were prepared. Arthritis individual was analyzed by histopathologic grading, genomic DNA examined simple sequence‐length polymorphism analysis to determine polymorphic microsatellite markers highly...
The aim of this study is to determine whether the 'programmed' infliximab (IFX) treatment strategy (for which dose IFX was adjusted based on baseline serum tumour necrosis factor α (TNF-α)) beneficial induction clinical remission after 54 weeks and sustained discontinuation for 1 year.In multicentre randomised trial, patients with IFX-naïve rheumatoid arthritis inadequate response methotrexate were two groups; in programmed group received 3 mg/kg until week 6 14 levels TNF-α 54; standard...
Objective Low-dose trimethoprim-sulfamethoxazole (TMP-SMX) is commonly used to prevent pneumocystis pneumonia in daily practice. Previous reports have shown a relationship between high- or standard-dose of TMP-SMX and hyperkalemia, however it remains unclear whether this true for low-dose TMP-SMX. In study we sought determine the risk factors hyperkalemia associated with Methods retrospective cohort study, 186 consecutive adult patients who received as prophylaxis from January 2014 2015 were...
Abstract Background The prophylaxis for hepatitis B virus (HBV) reactivation assumes that hepatic injury after is often rapidly progressive and can evoke fulminant hepatitis. incidence prognosis of in patients with rheumatoid arthritis (RA) may be different from those receiving organ transplantation cancer chemotherapy. This study aimed to investigate the incidence, risk factors, clinical course HBV develop a scoring system stratification RA resolved infection. Methods DNA was measured using...
We report a case of IgG4-related disease (IgG4-RD) with multiple ten-organ involvement. This showed many clinical findings, such as bilateral swelling salivary and lacrimal glands, autoimmune pancreatitis, interstitial nephritis, retroperitoneal fibrosis, periaortitis, systemic lymph nodes, pulmonary lesions, splenomegaly, jejunal lesions. He was suspected having SLE or malignant lymphoma but diagnosed IgG4-RD by the elevated serum IgG4 level histological findings from kidney node....
This study used data from a large-scale multicenter medical information database in Japan to estimate the incidence rate of herpes zoster (HZ) and examine relationship between hypertension, dyslipidemia, diabetes mellitus (DM), risk HZ among patients with rheumatoid arthritis (RA). The research dataset consisted 221,196 records potential target RA extracted April 1, 2008 August 31, 2017 Medical Data Vision database. To assess association DM HZ, case-control was set up. Records 101,498...
Abstract Objective To analyze the influence of genetic background an arthritis‐prone strain mice, MRL, on spontaneous development arthropathy in DBA/1 which histopathologically resembles enthesopathy humans, and to clarify strain‐specific gene loci their interactions that confer susceptibility arthropathy. Methods DBA/1, (MRL × DBA/1)F 1 , 2 intercross mice were prepared, severity onset ankle joints individual quantified (0–3 0–5 scale, respectively). A genome‐wide scan 271 male F with...
We report a case of neuropsychiatric systemic lupus erythematosus successfully treated with mycophenolate mofetil (MMF). The patient was 40-year-old female who maintained 7 mg prednisolone plus 100 azathioprine (AZ) per day. According to transient ischemic attack that occurred repeatedly and an elevated level interleukin-6 (IL-6) in spinal fluid, she diagnosed as having (NPSLE). Initial increase doses AZ 20 150 day, respectively, ineffective. After switching from MMF, her symptoms NPSLE...
Abstract Background Typical Lemierre’s syndrome is usually secondary to an oropharyngeal infection. Recently, several cases following a primary infection site other than the oropharynx have been reported as atypical syndrome; although, these lesions are limited head and neck. This first case potentially sequential infectious foci outside Case presentation We describe in 72-year-old woman with rheumatoid arthritis, which occurred during treatment of Streptococcus anginosus bacteremia acquired...
<h3>Background:</h3> Periprosthetic joint infections (PJIs) with bacterial culture-negative results are challenging to diagnose and manage. Biomarkers such as C-reactive protein alpha-defensin often reported be elevated in patients inflammatory rheumatic diseases. Therefore, it is difficult judge whether elevations biomarkers caused by infection or flare of a disease. To increase the sensitivity detecting causative microorganisms, number methods, including polymerase chain reaction (PCR),...
<h3>Background</h3> Although the reactivation of hepatitis B virus (HBV) is recognized as a serious complication in patients with connective tissue disease (CTD) receiving immunosuppressive drugs (ISDs), incidence and risk factors remain controversial. <h3>Objectives</h3> We performed multicentre, observational, prospective study across 16 Japanese Red Cross hospitals to clarify prevalence pathophysiology HBV CTD. report results 2-year observations resolved infection. <h3>Methods</h3>...
A cumulative effect of the susceptibility genes with polymorphic alleles may be responsible for rheumatoid arthritis (RA). The objective this study was to clarify whether RA is under control common allelic loci between two different models induced by extrinsic and intrinsic factors, collagen-induced (CIA) in DBA/1 mice MRL/Mp (MRL) associated Fas deficient mutant gene, Faslpr, respectively. CIA examined parental MRL, (MRL × DBA/1) F1 F2 progenies. In genome-wide screening severity using...
Vascular cell adhesion molecule‐1 (VCAM‐1, CD106) is important in leukocyte trafficking and its increased expression associated with a number of chronic inflammatory diseases, including rheumatoid arthritis (RA). A soluble form VCAM‐1 (sVCAM‐1) generated by shedding the membrane‐bound molecule. The concentration sVCAM‐1 sera RA patients, but pathological role has not been elucidated. effect relative to protection or aggravation disease on development spontaneous was examined an animal model...
Metatarsus primus elevatus, described as dorsal elevation of the first metatarsal in relation to lesser metatarsals, is rarely observed patients with rheumatoid arthritis. We describe a patient symptomatic forefoot deformity accompanied by metatarsus whose weight was not supported head. Instead, it transferred interphalangeal joint. The underwent proximal plantar flexion wedge osteotomy and distal shortening oblique osteotomies lateral metatarsals. At 1 year follow-up, she free from pain her...
Background: Denosumab, a fully human monoclonal antibody to receptor activator of nuclear factor kappa B ligand, which inhibits osteoclast differentiation, activation and survival, not only increases bone mineral density but also the progression erosion in patients with rheumatoid arthritis (RA) 1-3) . Therefore, denosumab have been preferably prescribed for RA recently. The persistence denosumab, is administered subcutaneously once every 6 months, was reported higher than oral...
Abstract Background To analyse the subsequent clinical course of patients with rheumatoid arthritis (RA) who either continued or discontinued biologic agents after hospitalization for infections. Methods We retrospectively reviewed records 230 RA 307 hospitalizations infections under therapy between September 2008 and May 2014 in 15 institutions up to 18 months discharge. The risks flares from 61 days discharge were evaluated. Results Survival analyses indicated that had a significantly...
Background: In the idividuals with genetic and enviromental risk factors, immune events at mucosal surfaces occur may precede systemic autoimmunity. Anti-citrullinated protein antibodies (ACPA) are present in serum for an average of 3-5 years prior to onset rheumatoid arthritis (RA) during asymptomatic period. ACPA-positivite individuals, additional presence RA-related factors appears add significant power development RA. To date, there have been few reports which clinical courses...
<h3>Background</h3> Serum and urinary pentosidine, an advanced glycation end-product (AGE), levels were increased in patients with rheumatoid arthritis (RA) when compared healthy controls. Antirheumatic medications including prednisolone, methotrexate anti-tumor necrosis factor agents affect the serum pentosidine levels. In long-standing RA who taking above medications, it might be difficult to evaluate whether disease activity or inflammation of To date no study characterize untreated is...
<h3>Background</h3> Both rheumatoid factor (RF) and anti–citrullinated protein antibody (ACP) are associated with bone damage in arthritis (RA). However, there has been little investigation into whether these autoantibodies could interact and/or contribute to orthopedic surgeries for RA patients. <h3>Objectives</h3> To investigate the role of RF ACP positivity status as a contributor <h3>Methods</h3> The study examined surgery database linkage RF/ACP data set. Patients were categorized...
<h3>Background</h3> Osteoporotic fragility fractures decrease physical performance and disability-free life expectancy. Patients with rheumatic disease develop osteoporosis due to local cytokine production, low levels of activity, glucocorticoid therapy. Rheumatologists need proactively manage in patients extend their healthy years. While studies have reported that approximately 50% postmenopausal discontinue anti-osteoporotic therapy within 1 year, there is a paucity data on treatment...