A5040305440- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Pneumonia and Respiratory Infections
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Spondyloarthritis Studies and Treatments
- Complement system in diseases
- Immunodeficiency and Autoimmune Disorders
- Bone and Joint Diseases
- Cytokine Signaling Pathways and Interactions
- Renal Diseases and Glomerulopathies
- Lymphoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Biosimilars and Bioanalytical Methods
- Myasthenia Gravis and Thymoma
- Natural product bioactivities and synthesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biological Activity of Diterpenoids and Biflavonoids
- HER2/EGFR in Cancer Research
- Tuberculosis Research and Epidemiology
- Cytomegalovirus and herpesvirus research
- Mesenchymal stem cell research
- Ophthalmology and Eye Disorders
- Sarcoidosis and Beryllium Toxicity Research
Beppu Medical Center
2012-2024
National Hospital Organization
2013-2022
American Thoracic Society
2014
European Respiratory Society
2014
Creative Commons
2014
Ibarakihigashi National Hospital
2014
Shizuoka City Shimizu Hospital
2014
National Institute of Technology, Yonago College
2014
Sumitomo Dainippon Pharma (United States)
2014
Omuta hospital
2014
The Japanese National Hospital Organization evidence-based medicine (EBM) Study group for Adverse effects of Corticosteroid therapy (J-NHOSAC) is a hospital-based cohort study investigating the safety initial use glucocorticoids (GCs) in patients with newly diagnosed autoimmune diseases. Using J-NHOSAC registry, purpose this observational to analyse rates, characteristics and associated risk factors intracellular infections diseases who were initially treated GCs.A total 604 GCs enrolled...
Pneumococcal pneumonia is the most frequent form of pneumonia. We herein assessed effectiveness 23-valent pneumococcal polysaccharide vaccine (PPSV23) in prevention overall rheumatoid arthritis (RA) patients at risk for infections. hypothesized that PPSV23 vaccination superior preventing compared with placebo RA patients.A prospective, multicenter, double-blinded, randomized, placebo-controlled (1:1) trial was conducted across departments rheumatology Japanese National Hospital Organization...
Objective In this study, we examine how advancements in novel antirheumatic drugs affect the clinicopathologic features of lymphoproliferative disorder (LPD) patients with rheumatoid arthritis (RA). Methods multicenter study across 53 hospitals Japan, characterized RA who developed LPDs and visited between January 1999 March 2021. The statistical tools used included Fisher's exact test, Mann‐Whitney U ‐test, log‐rank logistic regression analysis, Cox proportional hazards models. Results...
Vaccination against Streptococcus pneumoniae is recommended for rheumatoid arthritis (RA) patients receiving immunosuppressive treatments. The objective of this study was to evaluate the humoral response 23-valent pneumococcal polysaccharide vaccination (PPSV23) in RA methotrexate (MTX) alone or combination with a tumor necrosis factor inhibitor, golimumab (GOM). PPSV23 given 114 patients, who were classified into three groups: control (n = 35), MTX 55), and GOM + 24). Before 4 6 weeks after...
Interstitial lung disease (ILD) has a heterogeneous clinical presentation and establishing prognosis for these patients is challenging. We investigated the characteristics outcome of with idiopathic interstitial pneumonias (IIPs) connective tissue disease-associated (CTD-ILD). conducted multicenter prospective study on 104 diagnosed IIPs 29 CTD-ILD, which were newly treated corticosteroids initially. compared characteristics, high-resolution computed tomography (HRCT) imaging date, outcomes....
To examine whether or not earlier therapeutic intervention with methotrexate (MTX) prevents the development of rheumatoid arthritis (RA) in patients recent-onset undifferentiated (UA) showing high anti-citrullinated peptide antibody (ACPA) titers.The were divided into two groups, one was treated MTX (MTX+ group, n = 29), and other without (MTX- 19), disease-modifying anti-rheumatic drugs permitted groups before primary endpoint met. The is occurrence definite RA, it compared after 1 year.The...
Abstract Aim The purpose of this study was to assess 5‐year changes in physical function and factors associated with improvement among patients rheumatoid arthritis ( RA ) daily clinical practice, focusing on the effect treatments, including biologic agents, early stage disease course. Methods National Database Rheumatic Diseases by iR ‐net Japan NinJa searched for duration ≤ 2 years modified health assessment questionnaire mHAQ > 0 between 2004 2007, so that 510 were included final...
ABSTRACT Objectives The aim is to evaluate outcomes and risk factors for death in patients with rheumatoid arthritis (RA) who developed Pneumocystis pneumonia (PCP). Methods We included RA were diagnosed PCP at seven participating community hospitals between July 2005 October 2020. Clinical features compared survivors non-survivors. Disease-modifying antirheumatic drugs (DMARDs) before onset after recovery also examined. Results Seventy PCP, among them, 60 (85.7%) received methotrexate (MTX)...
<h3>Background</h3> Recent cumulative evidence suggests that early therapeutic intervention by DMARDs including MTX could prevent progression of RA. However, it is not clarified how and which population the patients should be taken DMARDs. Previously we reported with early-onset UA (EUA) showing high-titer anti-citrullinated peptide antibodies (ACPA) (>15 U/ml) developed RA within a year at high-rate (>80%) (ref.1). <h3>Objectives</h3> To examine whether very development in EUA ACPA....
To identify the determinant of patients' perspectives quality life (QOL) and working status out analysis-derived components underlying a set assessment measures patients with rheumatoid arthritis (RA).From NinJa database in Japan (2012-2014), 1455 RA DAS28 > 3.2 were recruited. Components explaining derived from principal component analysis 15 measures. Multivariate regression was used to examine relative contribution each identified EuroQOL-5 Dimension Questionnaire score status.Among...
<h3>Background</h3> Depression and anxiety have been recognized as prevalent in patients with rheumatoid arthritis (RA), but the exact prevalence among Japanese RA is unclear. <h3>Objectives</h3> We aimed to analyze factors associated depression using data from a large cohort database. <h3>Methods</h3> The 7,479 analyzed this study were enrolled National Database of Rheumatic Diseases by iR-net Japan (NinJa database), one largest clinical databases for during fiscal year 2013 results...
Abstract Background To analyse the subsequent clinical course of patients with rheumatoid arthritis (RA) who either continued or discontinued biologic agents after hospitalization for infections. Methods We retrospectively reviewed records 230 RA 307 hospitalizations infections under therapy between September 2008 and May 2014 in 15 institutions up to 18 months discharge. The risks flares from 61 days discharge were evaluated. Results Survival analyses indicated that had a significantly...
Abstract Twenty-six patients with systemic lupus erythematosus (SLE) showing activity measure (SLAM) and SLE disease index (SLEDAI) scores ≤2, as well a lower C4 concentration than the mean levels of healthy controls, were selected to evaluate in remission. Serum complement (CH50), components (C4, C3, B), split products (C4d, iC3b, Bb), phenotypic expression allotype, production by peripheral blood monocytes, lymphocyte subpopulation, interferon-gamma (IFN-γ) examined. In remission,...