A5071110972- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- NF-κB Signaling Pathways
- Chronic Lymphocytic Leukemia Research
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Sarcoidosis and Beryllium Toxicity Research
- Renal Diseases and Glomerulopathies
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Vasculitis and related conditions
- Bone and Joint Diseases
National Hospital Organization
2013-2024
Chiba University
1998
To evaluate the efficacious noninferiority of subcutaneous tocilizumab injection (TCZ-SC) monotherapy to intravenous TCZ infusion (TCZ-IV) in Japanese patients with rheumatoid arthritis (RA) an inadequate response synthetic and/or biologic disease-modifying antirheumatic drugs (DMARDs).This study had a double-blind, parallel-group, double-dummy, comparative phase III design. Patients were randomized receive TCZ-SC 162 mg every 2 weeks or TCZ-IV 8 mg/kg 4 weeks; no DMARDs allowed during...
ObjectiveGlomerulonephritis is frequent in ANCA-associated vasculitis (AAV) and crucial to disease outcomes. We conducted a detailed assessment of renal pathology Japanese patients with AAV, developed new score that would predict outcome.MethodsTwo-hundred-twenty-one who were diagnosed AAV underwent kidney biopsy enrolled. Data on glomerular, tubular, interstitial, vascular lesions from biopsies analyzed; the three established classification prognostic scoring systems (Berden Classification,...
The Japanese National Hospital Organization evidence-based medicine (EBM) Study group for Adverse effects of Corticosteroid therapy (J-NHOSAC) is a hospital-based cohort study investigating the safety initial use glucocorticoids (GCs) in patients with newly diagnosed autoimmune diseases. Using J-NHOSAC registry, purpose this observational to analyse rates, characteristics and associated risk factors intracellular infections diseases who were initially treated GCs.A total 604 GCs enrolled...
Abstract We examined the role of c-Fos in differentiation mature B cells into IgG-producing using transgenic mice carrying c-fos gene under control IFN-α/β-inducible Mx promoter (Mx-c-fos) or constitutive H-2Kb (H2-c-fos). Splenic from Mx-c-fos were cultured with LPS and rIL-4, IgG1+ developed culture after day 3. When IFN-α/β was added to 2, development perturbed, number apoptotic increased within 24 h, suggesting that induces apoptosis Ig class-switching cells. To confirm effect on cell...
Although high-dose glucocorticoids have been reported to cause new-onset diabetes mellitus (glucocorticoid-induced mellitus), its risk factors remained be determined. We investigated the related glucocorticoid-induced diagnosed within 2 months after treatment (newly treated with an initial high dose of > 20 mg prednisolone (PSL) equivalent per day for at least more than 6 months) in collagen vascular diseases.A total 2,631 patients diseases was registered between 1986 and 2006...
Objective We aimed to determine the prevalence and risk factors for osteonecrosis of femoral head (ONFH) in a multicentre cohort patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Methods One hundred eighty-six AAV who underwent radiographs MRI screening bilateral hip joints at more than 6 months after initial remission induction therapy (RIT) were retrospectively assessed presence ONFH. Results Among 186 patients, 33 (18%) diagnosed ONFH, 55% asymptomatic 64% had...