A5054279320- Acute Myeloid Leukemia Research
- Biochemical and Molecular Research
- Gout, Hyperuricemia, Uric Acid
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cytomegalovirus and herpesvirus research
- Retinoids in leukemia and cellular processes
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- HIV/AIDS drug development and treatment
- Adenosine and Purinergic Signaling
- Antifungal resistance and susceptibility
- Hematopoietic Stem Cell Transplantation
- Fungal Infections and Studies
- Hematological disorders and diagnostics
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer therapeutics and mechanisms
- Muscle and Compartmental Disorders
- Neutropenia and Cancer Infections
- Pneumonia and Respiratory Infections
- Immunodeficiency and Autoimmune Disorders
- Cancer Treatment and Pharmacology
- Rheumatoid Arthritis Research and Therapies
National Hospital Organization
2011-2024
American Thoracic Society
2014
European Respiratory Society
2014
Creative Commons
2014
Ibarakihigashi National Hospital
2014
Shizuoka City Shimizu Hospital
2014
National Institute of Technology, Yonago College
2014
Sumitomo Dainippon Pharma (United States)
2014
Omuta hospital
2014
Committee on Publication Ethics
2014
The Japanese National Hospital Organization evidence-based medicine (EBM) Study group for Adverse effects of Corticosteroid therapy (J-NHOSAC) is a hospital-based cohort study investigating the safety initial use glucocorticoids (GCs) in patients with newly diagnosed autoimmune diseases. Using J-NHOSAC registry, purpose this observational to analyse rates, characteristics and associated risk factors intracellular infections diseases who were initially treated GCs.A total 604 GCs enrolled...
Pneumococcal pneumonia is the most frequent form of pneumonia. We herein assessed effectiveness 23-valent pneumococcal polysaccharide vaccine (PPSV23) in prevention overall rheumatoid arthritis (RA) patients at risk for infections. hypothesized that PPSV23 vaccination superior preventing compared with placebo RA patients.A prospective, multicenter, double-blinded, randomized, placebo-controlled (1:1) trial was conducted across departments rheumatology Japanese National Hospital Organization...
Objective In this study, we examine how advancements in novel antirheumatic drugs affect the clinicopathologic features of lymphoproliferative disorder (LPD) patients with rheumatoid arthritis (RA). Methods multicenter study across 53 hospitals Japan, characterized RA who developed LPDs and visited between January 1999 March 2021. The statistical tools used included Fisher's exact test, Mann‐Whitney U ‐test, log‐rank logistic regression analysis, Cox proportional hazards models. Results...
A novel long-term cultured myeloid cell line was established from the bone marrow of a patient with myelodysplastic syndrome (MDS). This line, designated MDS92, proliferated in presence interleukin-3 or granulocyte-macrophage colony-stimulating factor and transiently Steel factor, tendency for gradual maturation, formed colonies semi-solid culture condition. In addition, MDS92 represented rather complicated karyotypic abnormalities including deletion fifth seventh chromosomes point mutation...
Summary. The expression of interleukin‐2 receptors (IL‐2R) was examined in 328 adult patients with non‐T‐cell (non‐T) acute leukaemia and blast crisis chronic myelocytic (CML.BC) using two monoclonal antibodies, anti‐Tac for IL‐2R α chain (IL‐2Rα) Mikβ1 β (IL‐2Rβ). Leukaemic cells the following cases were positive anti‐Tac; 28/192 (AML), 24/44 CML‐BC, 4/28 CD19(+)CD10(‐) lympho‐blastic (ALL), 20/64 common ALL (c‐ALL). IL‐2Rβ not detected on leukaemic any case examined. Eleven IL‐2Rα(+) AML...
The authors examined the expression of myeloid antigens (MyAg): CDMb, CDI3, CD14, CD15, and CD33 in 249 adults with lymphoid neoplasms using flow cytometric analysis. In this study, acute leukemia that was myeloperoxidase negative by light microscopy had at least one antigen defined as lymphoblastic (ALL). patients were classified follows: 6 unclassified ALL, 35 early B precursor 32 T-ALL, 25 B-cell chronic lymphocytic (B-CLL) its variants, 24 non-Hodgkin's lymphoma (B-NHL), 7 plasma cell...
Vaccination against Streptococcus pneumoniae is recommended for rheumatoid arthritis (RA) patients receiving immunosuppressive treatments. The objective of this study was to evaluate the humoral response 23-valent pneumococcal polysaccharide vaccination (PPSV23) in RA methotrexate (MTX) alone or combination with a tumor necrosis factor inhibitor, golimumab (GOM). PPSV23 given 114 patients, who were classified into three groups: control (n = 35), MTX 55), and GOM + 24). Before 4 6 weeks after...
Survivin is a member of the inhibitor apoptosis protein (IAPs) family and considered to play pivotal role in oncogenesis. We present first report survivin expression profile myelodysplastic syndrome (MDS). Expression messenger RNA was evaluated by semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) patients with MDS acute myeloid leukemia (AML). Eleven out 12 refractory anemia (RA) (91.6%), all 3 excess blasts transformation (RAEBt) (100%), were positive for majority...
We report the cellular characteristics of cells from three patients with de novo acute myelocytic leukaemia (AML) t(16;21)(p11;q22), two M4 and one M5a according to FAB classification, permanent cell lines TSU1621MT YNH-1. The FUS/ERG fusion mRNA was demonstrated in all cases by reverse transcriptase-polymerase chain reaction (RT-PCR). immunophenotypes AML cells, YNH-1 t(16;21) were characterized as CD34+CD33+CD13+CD11b+CD18+CD56+ HLA-DR-/+. Cells samples strongly expressed c-kit,...
Interstitial lung disease (ILD) has a heterogeneous clinical presentation and establishing prognosis for these patients is challenging. We investigated the characteristics outcome of with idiopathic interstitial pneumonias (IIPs) connective tissue disease-associated (CTD-ILD). conducted multicenter prospective study on 104 diagnosed IIPs 29 CTD-ILD, which were newly treated corticosteroids initially. compared characteristics, high-resolution computed tomography (HRCT) imaging date, outcomes....