A5076829080- Bladder and Urothelial Cancer Treatments
- Amyotrophic Lateral Sclerosis Research
- Soybean genetics and cultivation
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Urinary and Genital Oncology Studies
- Hematopoietic Stem Cell Transplantation
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Legume Nitrogen Fixing Symbiosis
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
- Esophageal and GI Pathology
- Acute Myeloid Leukemia Research
- Parkinson's Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Hepatitis C virus research
- Exercise and Physiological Responses
- Renal cell carcinoma treatment
- Esophageal Cancer Research and Treatment
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Leprosy Research and Treatment
- Multiple and Secondary Primary Cancers
Matsuyama Shimin Hospital
2016-2025
Yokohama National University
1986-2024
University of Electro-Communications
2013-2024
Osaka Hospital
2016-2024
Okayama University of Science
2019-2024
Genesis Research Institute
2021-2024
Osaka Metropolitan University
2024
The University of Tokyo
2006-2023
Musashino Red Cross Hospital
2003-2023
Toray Industries, Inc. (Japan)
2004-2023
The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different kinases: MKK3, MKK4, and MKK6. To examine the relative roles of these kinases mechanism MAP activation vivo, we examined effect disruption murine Mkk3, Mkk4 , Mkk6 genes on MAPK signaling pathway. We show that MKK3 MKK6are essential for tumor necrosis factor-stimulated activation. In contrast, ultraviolet radiation-stimulated was mediated Loss mutant cells associated with defects growth arrest increased...
The penetration of various viruses into host cells is accomplished by hijacking the endocytosis machinery. In case severe acute respiratory syndrome coronavirus (SARS-CoV) infection, viral entry reported to require a low pH in intracytoplasmic vesicles; however, little known about how SARS-CoV invades such compartments. Here we demonstrate that mainly utilizes clathrin-mediated pathway for its target using infectious SARS-CoV, as well pseudovirus packaged envelope. entered...
We have searched the human genome for genes that predispose to rheumatoid arthritis (RA) using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study. A panel of 41 Japanese families, each with at least two siblings, was typed genome-wide 358 polymorphic loci. Markers were amplified by PCR fluorescence-tagged primers sized based on difference CA repeats DNA. Linkage made maximum lod score (MLS). The MLS D1S214 D8S556 3.27 3.33, while HLA-DRB1 region <3.0....
Progranulin (PGRN) haploinsufficiency resulting from loss-of-function mutations in the PGRN gene causes frontotemporal lobar degeneration accompanied by TDP-43 accumulation, and patients with homozygous present neuronal ceroid lipofuscinosis. Although it remains unknown why deficiency neurodegenerative diseases, there is increasing evidence that implicated lysosomal functions. Here, we show a secretory protein regulates function biogenesis controlling acidification of lysosomes. expression...
It has been shown that progranulin (PGRN) deficiency causes age-related neurodegenerative diseases such as frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL), a lysosomal storage disease. Previous studies also suggested PGRN is involved in modulating function. To elucidate the pathophysiological role of aged brain, present study, function pathological changes brain were investigated using 10- 90-week-old wild-type PGRN-deficient mice. We showed caused enhanced...
In the central nervous system, progranulin, a glycoprotein growth factor, plays crucial role in maintaining physiological functions, and progranulin gene mutations cause TAR DNA-binding protein-43-positive frontotemporal lobar degeneration. Although several studies have reported that protective against ischaemic brain injury, little is known about temporal changes expression level, cellular localization, glycosylation status of after acute focal cerebral ischaemia. addition, precise...
The superiority of the pediatric protocol for adolescents with acute lymphoblastic leukemia (ALL) has already been demonstrated, however, its efficacy in young adults remains unclear. ALL202-U was conducted to examine and feasibility a (AYAs) BCR-ABL-negative ALL. Patients aged 15-24 years (n=139) were treated same used B-ALL. primary objective this study assess disease-free survival (DFS) rate secondary aims toxicity, complete remission (CR) overall (OS) rate. CR 94%. 5-year DFS OS rates...
Comprehensive genomic profiling (CGP) is increasingly used as a clinical laboratory test and being applied to cancer treatment; however, standardization external quality assessments (EQA) have not been fully developed. This study performed cost-effective EQA proficiency tests (PT) for CGP testing among multiple institutions those belong the working group of Japan Association Clinical Laboratory Science (JACLS). revealed that preanalytical processes, such derived nucleic acids (NA) extraction...
Laparoscopic left adrenalectomy was performed on a 47 years old male patient with primary aldosteronism. Subcutaneous steel traction method utilized in addition to intraperitoneal CO2 insufflation method. The combined use of reduced pressure below 12mmHg and might reduce possibility CO2-related complications. A adrenal gland approached by resection phrenicocolic ligament transverse descending colon. has distinct advantages over open terms avoidance skin muscle incision rib resection, early...
No AccessJournal of UrologyOriginal Articles1 May 1993Laparoscopic Adrenalectomy: The Initial 3 Cases Eiji Higashihara, Yoshinori Tanaka, Shigeo Horie, Seiji Aruga, Kikuo Nutahara, Shigeru Minowada, and Yoshio Aso HigashiharaEiji Higashihara More articles by this author , TanakaYoshinori Tanaka HorieShigeo Horie ArugaSeiji Aruga NutaharaKikuo Nutahara MinowadaShigeru Minowada AsoYoshio View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)36271-7AboutPDF ToolsAdd to...
Abstract Purpose: The purpose of this study was to identify proteins that are potentially involved in the tumor invasion bladder cancer. Experimental Design: We searched for candidate by comparing profiles secreted among poorly invasive human carcinoma cell line RT112 and highly T24. isolated from culture supernatants were identified shotgun proteomics. found CXCL1 is related cancer cells. also evaluated whether amount chemokine urine would be a potential marker predicting existence tumors....
Aim The predictors for the development of hepatocellular carcinoma (HCC) after direct‐acting antiviral (DAA) treatment were investigated. Methods A total 1174 patients with chronic hepatitis C virus infection treated DAA therapy (sofosbuvir and ledipasvir [ n = 615], sofosbuvir ribavirin 380], daclatasvir asunaprevir 179]) achieved sustained virologic response (SVR). HCC rate factors that might contribute to end analyzed. Results During median observation period 537 days, developed in 33...
Interleukin 6 (IL-6), a pleiotropic cytokine, functions in cells through its interaction with receptor complex, which consists of two ligand-binding alpha subunits and signal-transducing known as gp130. There is wealth studies on signals mediated by gp130, but downregulation less well understood. Here we found that IL-6 stimulation induced lysosome-dependent degradation correlated an increase the K63-linked polyubiquitination The stimulation-dependent ubiquitination gp130 was c-Cbl, E3...