A5103151445- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Geological and Geochemical Analysis
- Hepatitis C virus research
- Mercury impact and mitigation studies
- Glycosylation and Glycoproteins Research
- HIV/AIDS Research and Interventions
- Radiopharmaceutical Chemistry and Applications
- T-cell and B-cell Immunology
- RNA and protein synthesis mechanisms
- Radioactive element chemistry and processing
- Heavy metals in environment
- Mycobacterium research and diagnosis
- Environmental Quality and Pollution
- Geochemistry and Elemental Analysis
- Cancer-related gene regulation
- Geochemistry and Geologic Mapping
- SARS-CoV-2 and COVID-19 Research
- Healthcare and Venom Research
- Cervical Cancer and HPV Research
- Tuberculosis Research and Epidemiology
- Maternal Mental Health During Pregnancy and Postpartum
Gansu University of Traditional Chinese Medicine
2025
Harbin Medical University
2009-2025
Fujian Medical University
2025
East China University of Technology
2022-2024
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Sichuan Cancer Hospital
2024
University of Electronic Science and Technology of China
2024
Xiamen University
2007-2023
Chinese Academy of Geological Sciences
2023
The penetration of various viruses into host cells is accomplished by hijacking the endocytosis machinery. In case severe acute respiratory syndrome coronavirus (SARS-CoV) infection, viral entry reported to require a low pH in intracytoplasmic vesicles; however, little known about how SARS-CoV invades such compartments. Here we demonstrate that mainly utilizes clathrin-mediated pathway for its target using infectious SARS-CoV, as well pseudovirus packaged envelope. entered...
Objective: HIV-1 isolates are prominently CD4-dependent and, to date, only a few laboratory-adapted CD4-independent strains have been reported. Therefore, whether viruses may exist in HIV-1-infected patients has remained unclear. Here, we report the successful isolation of clinical strain, designated SDA-1, from viral quasispecies therapy-naive and Pneumocystis jirovecii pneumonia patient late-stage AIDS with extremely low CD4 cell count (CD4 = 1/μl). We characterized this virus further...
Pandemic 2009 H1N1 influenza A virus (2009 H1N1) differs from strains that circulated in the past 50 years, but resembles A/New Jersey/1976 strain used 1976 swine vaccine. We investigated whether sera persons immunized with or recent seasonal vaccines, both, neutralize H1N1. Using retroviral pseudovirions bearing hemagglutinins on their surface (HA-pseudotypes), we found 77% of collected after immunization vaccine neutralized Forty five percent also Caledonia/20/1999 H1N1, a vaccines during...
Hesperetin (HST), a natural flavonoid, has potent antitumor effects on lung adenocarcinoma; however, its squamous cell carcinoma (LUSC) are currently unknown. The present study aimed to investigate the anticancer of HST LUSC cells. influence 37.5, 75 and 150 <em>µ</em>M H1703 line, 75, 300 H226 line was determined using Cell Counting Kit‑8 method, cycle assay, JC‑1 mitochondrial membrane potential assay Annexin V‑FITC/PI staining. DMSO‑treated cells were used as control group. Western...
Currently, most people living with HIV (PLWH) in China have a strong awareness of diagnosis and treatment the early stage infection. Subtype-specific virological immunological features recently infected PLWH not yet been elucidated. Data including CD4 count viral load (VL) 1508 anti-retroviral therapy (ART) -naïve were obtained from Database comparatively analyzed among different subtypes. The infection status 402 newly diagnosed ART-naïve cohort men who sex (MSM) was evaluated using records...
Peptides corresponding to N- and C-terminal heptad repeat regions (HR1 HR2, respectively) of viral fusion proteins can block infection viruses in a dominant negative manner by interfering with refolding the HR1 HR2 form six-helix bundle (6HB) that drives between host cell membranes. The 6HB HIV gp41 (endogenous bundle) consists an coiled-coil trimer grooves lined antiparallel helices. peptides oligomers may bind as trimers heterologous (inhibitor or monomers dimers coiled coil. To gain...
We generated four HIV-1 cultures that are resistant to a peptide fusion inhibitor corresponding the first heptad repeat of gp41 in order study mechanisms resistance and gain insights into envelope glycoprotein-mediated membrane fusion. Two genetic pathways emerged were defined by acquisition specific mutation either or second region (HR1 HR2, respectively). Each pathway was enriched mutations clustered HR2 V3 HR1 residues near CD4 contact sites. The both not only accounted for selecting but...
The Huanglongpu deposit is one of the most representative igneous carbonatite-type molybdenum-rare earth element (Mo-REE) deposits in eastern Qinling metallogenic region. molybdenum resources exceed 180 kt, whilst total rare are about 37.8 kt. However, age REE mineralization, sources ore-forming minerals, and tectonic setting not well characterized. Therefore, this study carried out detailed mineralogical, geochronological, geochemical analyses to provide new insights. Monazite, bastnäsite,...
The HIV-1 envelope glycoprotein (Env) undergoes conformational changes that mediate fusion between virus and host cell membranes. These involve transient exposure of two heptad-repeat domains (HR1 HR2) in the gp41 subunit their subsequent self-assembly into a six-helix bundle (6HB) drives fusion. Env residues features influence rate entry, however, are poorly understood. Peptides corresponding to HR1 HR2 (N C peptides, respectively) interrupt formation 6HB by binding heptad repeats...
The current standard of care for metastatic prostate cancer (mPCa) is androgen deprivation therapy (ADT) with or without anti-androgen and chemotherapy. aim this study was to evaluate the efficacy safety a multimodal approach including local primary tumor therapy, metastasis-directed (MDT), hormonal in patients oligometastatic (PCa).We reviewed data PCa bone oligometastases at diagnosis treated three institutions ADT followed by cytoreductive surgery metastases-directed radiotherapy....
While protective measures in response to infectious diseases may reduce the freedom of tourists (regarding their behaviors), few studies have documented effects destination on self-protective behaviors tourists. By applying protection motivation theory, this study examines perceived supports social distancing intentions during COVID-19 pandemic. The results reveal significant relationships among support, coping appraisal, threat and Moreover, two cognitive appraisals-toward...
The Yuqia uranium deposit is a newly discovered sandstone-type in the northern margin of Qaidam Basin. Concerning sources sediment basin, most scholars have focused on study Cenozoic part rather than Jurassic provenance and its implications for mineralization. In this paper, sandstones area were selected petrography, petrogeochemistry electron microprobe analysis (EPMA), significance sedimentary metallogeny further discussed, based previous data detrital zircon chronology. It reported here...
The objective of this research was to determine the relationship between YMDD mutations and genotypes hepatitis B virus (HBV) during lamivudine treatment. HBV were determined by nested PCR with 6 pairs genotype-specific primers (A F) in serum specimens from 142 patients receiving antiviral therapy. detected fluorescent hybridization bioprobe melting curve assay (FH-PCR-MC). Among specimens, 13 samples genotype (9.2%), 125 C (88%), 4 D (2.8%), 80 found. mutation rates 69.2 54.4% C,...
The importance of the fourth variable (V4) region human immunodeficiency virus 1 (HIV-1) envelope glycoprotein (Env) in infection has not been well clarified, though polymorphism this found to be associated with disease progression acquired syndrome (AIDS). In present work, we focused on correlation between HIV-1 gp120 V4 and function entry, possible mechanisms for how contributes infectivity. Therefore, analyzed differences sequences along coreceptor usage preference from CCR5 CXCR4...
Kidney and prostate cancers are leading causes of death in the world, accumulating evidence suggests that tumor suppressor gene, Krüppel-like factor 6 (KLF6), plays an important role both development progression cancer. However, effect wild type KLF6 (wtKLF6) on growth potential renal carcinoma cells has not been examined. In present study, we therefore introduced wtKLF6 gene into a prostatic derived cell line, DU145, OS-RC-2, have established DU145-KLF6 OS-RC-2-KLF6 lines, which stably...
The membrane proximal external region (MPER) of the gp41 subunit HIV-1 envelope glycoprotein (Env) contains determinants for broadly neutralizing antibodies and has remained an important focus vaccine design. However, creating immunogen that elicits to this proven difficult in part due relative inaccessibility MPER native conformation Env. Here, we describe antigenicity immunogenicity a panel oligomeric immunogens designed model fusion-intermediate Env order enhance exposure relevant...