A5028392400- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Pregnancy-related medical research
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Extracellular vesicles in disease
- Endometrial and Cervical Cancer Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Apelin-related biomedical research
- Liver Disease and Transplantation
- Maternal Mental Health During Pregnancy and Postpartum
- Pediatric Hepatobiliary Diseases and Treatments
- Menstrual Health and Disorders
- Reproductive tract infections research
- Indigenous Studies and Ecology
- Infant Nutrition and Health
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- RNA modifications and cancer
- Hormonal Regulation and Hypertension
- Mesenchymal stem cell research
- Pulmonary Hypertension Research and Treatments
- Vitamin C and Antioxidants Research
- Neuroendocrine regulation and behavior
Nanjing Medical University
2025
Changzhou No.2 People's Hospital
2025
Shandong Provincial Hospital
2022-2024
Shandong First Medical University
2023-2024
Jinzhou Medical University
2024
Shandong University
2019-2023
Shandong Maternal and Child Health Hospital
2023
Suzhou Research Institute
2023
China Medical University
2023
Qilu Hospital of Shandong University
2021-2022
Background Endometriosis is a common nonmalignant gynecological disorder that affects 10–15% women of reproductive age and causes several symptoms result in decreased quality life huge social burden. In recent decades, extracellular vesicles (EVs) have gained attention as potential therapeutic tool; however, the effects EVs against endometriosis not been reported. Accordingly, this study, we investigated feasibility nanovesicles (NVs) derived from M1 macrophages (M1NVs) treating...
Patients with premenopausal breast cancer (preBC) usually have long-term survivorship. However, less is known about the risk pattern of subsequent primary (SPC) and noncancer diseases among them. Here, this study aimed to evaluate developing SPCs mortality preBC survivors. In population-based, retrospective cohort study, 5-year survivors diagnosed at age 20-59 years during 1992-2014, in 11 Surveillance, Epidemiology End Result registries were included. Standardized incidence ratio (SIR)...
Peritoneal macrophages play a significant role in the progression of endometriosis (EM), but their functional differentiation is still unclear, and phagocytic ability weak. CD47-signal-regulated protein α (SIRPα) PD-L1-PD-1 are considered immune checkpoints associated with macrophage phagocytosis. A specific blockade these two pathways had been shown to increase clearance cancer cells by most cancers. We hypothesized that targeting CD47/PD-L1 EM could improve phagocytosis macrophages,...
The main symptoms of adenomyosis may adversely affect physical and mental health quality life (QOL). However, studies are few on this topic. This study evaluated the effect anxiety, depression, QOL. Participants with (n = 90) or leiomyoma 59) completed questionnaires, including visual analog scale (VAS) for pain, Hospital Anxiety Depression Scale (HADS), Short Form (SF)-36. HADS anxiety depression positive rates, (PCS) (MCS) component summary scores, eight subscale scores SF-36 were compared...
To study the efficacy and safety of dienogest gonadotropin-releasing hormone agonist (GnRH-a) in symptomatic females with uterine adenomyosis.A total 127 patients adenomyosis a chief complaint dysmenorrhea were recruited. The first group received 2 mg (DNG) daily, whereas second goserelin acetate (GS) (3.6 mg/4 weeks) for 12 weeks. Outpatient follow-up was undertaken after weeks.Among women, 56/63 (88.9%) completed treatment DNG group, 62/64 (96.9%) GS group. A significant decrease symptoms...
Changes in the function of peritoneal macrophages contribute to homeostasis immune microenvironment endometriosis. The mechanism by which ectopic tissues escape phagocytic clearance achieve colonization and proliferation is unknown. expression CD163 patients with endometriosis increased, overexpression MAPK , can promote M2-type polarization reduce their ability phagocytose endometrial cells. As an upstream regulator MST1 deficient This process regulated miR-887-5p, a noncoding RNA targeting...
Immune dysregulation has long been proposed to be associated with adenomyosis, but the underlying mediators and mechanisms remain largely unexplored. Here, we used flow cytometry investigate alterations in immune cell subsets adenomyotic uteri analyze phenotype function of abnormal cells. We found that an increase cluster differentiation (CD)8+ T-cell number was predominant alteration ectopic lesions patients adenomyosis significantly severity adenomyosis. Importantly, identified exhausted...
Abstract Ferroptosis is an iron-dependent programmed cell death process characterized by the accumulation of lethal oxidative damage. Localized iron overload a unique clinical phenomenon in ovarian endometriosis (EM). However, role and mechanism ferroptosis course EM remain unclear. Traditionally, autophagy promotes survival. growing body research suggests that under certain conditions. This study aimed to clarify status explore mechanism(s) which causes ectopic endometrial resistance human....
Abstract The development of endometriosis is closely linked to macrophages, and the type M1 macrophage has been hypothesized play an inhibitory role in its progression. Escherichia coli induces polarization toward numerous diseases differs reproductive tract patients with without endometriosis; however, specific remains unknown. Therefore, this study, E. was selected as a stimulator induce effects on growth lesions vitro vivo were investigated using C57BL/6N female mice endometrial cells. It...
Abstract Background To determine whether there is a correlation between stiffness measured by strain elastography and the severity of dysmenorrhea to value in evaluating severe patients with adenomyosis. Methods The tissue was analyzed performing on premenopausal women diagnosed Expression levels transforming growth factor-β (TGF-β), α-smooth muscle actin (α-SMA), protein gene product 9.5 (PGP9.5) were detected immunohistochemistry; TGF-β α-SMA degree fibrosis further analyzed. Also,...
Abstract Background Adenomyosis is a commonly observed benign gynecological disease that affects the quality of life and social psychology women childbearing age. However, because unknown etiology incidence adenomyosis, its pathophysiological mechanism remains unclear; further, no noninvasive, accurate, individualized diagnostic methods are available, treatment efficacy evaluations limited. Notably, interaction between changes in microecological environment female reproductive tract human...
Breast cancer, a most common malignancy among women with high lethality. Polypeptide-N-acetyl-galactosaminlytransferase 7 (GALNT7) contributes to carcino-genesis and development of breast cancer. Activation signal transducer activator transcription 3 (STAT3) is vital in the initiation cancers. In this work, GALNT7 was upregulated cancer cells, promoted cell proliferation. knockdown suppressed proliferation cells. overexpression B-cell lymphoma protein 2 (BCL2) expression levels...
Pulmonary hypertension (PH) is a progressive and life-threatening condition. Recent research has demonstrated that exosomes derived from mesenchymal stem cells (MSC) exhibit significant therapeutic potential in the treatment of PH. The composition these often substantially influenced by characteristics their parental cells. This study aimed to identify an intervention strategy enhance efficacy cell treating Exosomes were isolated control MSC tadalafil-pretreated MSCs. In vitro vivo studies...
Objective: To explore the role and related mechanisms of angiotensin-(1-7)(Ang-(1-7)) on Toll-like receptor 4 (TLR4) mediated oxidized low-density lipoprotein(ox-LDL)-induced oxidative stress in human umbilical vein endothelial cells (HUVECs). Methods: HUVECs were cultured vitro divided into six groups: control group (normal medium), ox-LDL group(treated with 75 mg/L ox-LDL), ox-LDL+ Ang-(1-7) (1 μmol/L pretreated for 30 minutes, then intervened Ang-(1-7)+ A-779 group(1 (Mas receptor) 1...
Objective This prospective cohort study aimed to compare the clinical efficacy and safety of goserelin 10.8 mg administered trimonthly with 3.6 monthly in premenopausal females symptomatic adenomyosis.Methods We recruited 139 adenomyosis who complained dysmenorrhea and/or menorrhagia. The first group (n = 70) received a single subcutaneous injection mg, second 69) for 3 months. Follow-up was performed at outpatient department after 12 weeks.Results Ultimately, 130 patients completed study,...
The management of endometriosis has been complicated by the COVID-19 pandemic. We aimed to introduce establishment and application a new follow-up method during pandemic—the electronic (e-follow-up) platform for endometriosis—and test applicability platform-based model patient satisfaction. used information entry post-operative 152 patients with from January 2021 August 2022, compared patients’ Zung’s Self-Rating Depression Scale (SDS), Anxiety (SAS), Visual Analogue Score (VAS) (range: 0 −...
Abstract Study question Is there dysregulation of immune cells in the local uterine microenvironment patients with adenomyosis? If any, what’s underlying mediators and mechanisms? Summary answer Increased CD8+ T-cell exhaustion due to enhanced HLA-E/NKG2A engagement IL-15 induction ectopic adenomyotic lesions existed human mice models adenomyosis. What is known already The immunological dysfunction has long been considered pathogenesis However, high heterogeneity cell alterations...
<title>Abstract</title> Background Adenomyosis is a commonly observed benign gynecological disease that affects the quality of life and social psychology women childbearing age. However, because unknown etiology incidence adenomyosis, its pathophysiological mechanism remains unclear; further, no noninvasive, accurate, individualized diagnostic methods are available, treatment efficacy evaluations limited. Notably, interaction between changes in microecological environment female reproductive...