A5100644251- Retinal Diseases and Treatments
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Biological and pharmacological studies of plants
- Dermatology and Skin Diseases
- Extracellular vesicles in disease
- Retinal Imaging and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Immune cells in cancer
- Glaucoma and retinal disorders
- Cytokine Signaling Pathways and Interactions
- Hippo pathway signaling and YAP/TAZ
- Circular RNAs in diseases
- Autoimmune and Inflammatory Disorders Research
- IL-33, ST2, and ILC Pathways
- Immunodeficiency and Autoimmune Disorders
- Wnt/β-catenin signaling in development and cancer
- Ginseng Biological Effects and Applications
- Asthma and respiratory diseases
- Kawasaki Disease and Coronary Complications
- PARP inhibition in cancer therapy
- Biochemical Acid Research Studies
- Vascular Malformations and Hemangiomas
Shanghai Tenth People's Hospital
2019-2024
Tongji University
2019-2024
Second Military Medical University
2022
Changhai Hospital
2022
Shanghai Skin Disease Hospital
2021
State Administration of Traditional Chinese Medicine of the People's Republic of China
2016-2019
Shanghai University of Traditional Chinese Medicine
2015-2019
Institute of Chinese Materia Medica
2016
Shanghai Institute of Materia Medica
2016
Shanghai University
2014-2015
Blood‐retinal barrier (BRB) breakdown is a typical event in the early stage of diabetic retinopathy (DR). This study aims to elucidate protection erianin, natural compound isolated from Dendrobium chrysotoxum Lindl, against DR development. Erianin alleviated BRB and rescued reduced claudin1 occludin expression retinas streptozotocin‐induced mice. microglial activation, ERK1/2 phosphorylation, NF‐κB transcriptional elevated TNF‐α both vitro vivo. inhibitor U0126 abrogated activation...
Erianin is a natural compound found in Dendrobium chrysotoxum Lindl. Diabetic retinopathy (DR) serious and common microvascular complication of diabetes. This study aims to investigate the inhibitory mechanism erianin on retinal neoangiogenesis its contribution amelioration DR. blocked high glucose (HG)-induced tube formation migration choroid-retinal endothelial RF/6A cells. inhibited HG-induced vascular growth factor (VEGF) expression, hypoxia-inducible 1-alpha (HIF-1α) translocation into...
Diabetic retinopathy (DR) is a serious complication of diabetes mellitus. This study aimed to observe the alleviation ethanol extract Dendrobium chrysotoxum Lindl. (DC), traditional Chinese herbal medicine, on DR and its engaged mechanism. After DC (30 or 300 mg/kg) was orally administrated, breakdown blood retinal barrier (BRB) in streptozotocin- (STZ-) induced diabetic rats attenuated by DC. Decreased mRNA expression tight junction proteins (including occludin claudin-1) also reversed...
Psoriasis is a chronic, inflammatory skin disease, frequently associated with dyslipidemia. Lipid disturbance in psoriasis affects both circulatory system and cutaneous tissue. Epidermal Langerhans cells (LCs) are tissue-resident DCs that maintain immune surveillance mediate various disorders, including psoriasis. However, the role of LCs development their lipid metabolic alternation remains unclear. Here, we demonstrate epidermal patients enlarge longer dendrites possess elevated IL-23p19...
Objectives To Investigate the association between systemic inflammatory indicators and psoriasis in adult population of United States. Methods We analyzed data from 16,575 participants National Health Nutrition Examination Survey (NHANES) conducted years 2003-2004 2009-2014. employed multivariable logistic regression nonlinear curve fitting methods, which allowed us to evaluate associations inflammation such as NPAR, NLR, NHR, LHR, PHR, MHR. Furthermore, subgroup analyses were performed...
Angiogenesis is a process of development and growth new capillary blood vessels from pre-existing vessels. Angiogenic factors play important roles in the maintenance some malignancies, which vascular endothelial factor (VEGF)/VEGFR2 interactions are involved proliferation, migration, survival many cancer cells. The aim this study was to investigate function VEGFR2 human hemangiomas (HAs). Using immunohistochemistry assay, we examined expression levels VEGF, VEGFR2, Ki-67, glucose...
The Goto-Kakizaki (GK) rat is a genetic model of type 2 diabetes. Diabetic retinopathy (DR) common complication In this study, we observed the development DR in GK rats and expression some angiogenesis-related signals. were housed for 5, 6 7 months. Results retinal vessels stained by cluster differentiation 31 (CD31) showed that number was increased at both Retinal histological observation also evidenced such increase. mRNA hypoxia inducible factor-1α (HIF-1α), vascular endothelial growth...
Background: Psoriasis is a common immune-mediated skin disease that involves T-cell-mediated immunity. Invariant natural killer T (iNKT) cells are unique lymphocyte subpopulation share properties and express surface markers of both NK cells. Previous reports indicate iNKT regulate the development various inflammatory diseases. IL-17 key cytokine in pathogenesis psoriasis therapeutic target. Secukinumab fully human IgG1κ antibody targets IL-17A, thereby antagonizing biological effects IL-17....
Psoriasis is an immune-mediated chronic inflammatory skin disease primarily mediated by the activation of interleukin (IL)-17-producing T cells. Traditional Chinese Medicine (TCM) represents one most effective complementary and alternative medicine (CAM) agents for psoriasis, which provides treasured sources development anti-psoriasis medications. Xiao-Yin-Fang (XYF) empirically developed TCM formula that has been used to treat psoriasis patients in Shanghai Changhai Hospital over three...
Introduction Herein, we developed an engineered extracellular vehicle (EV)-based method for ameliorating inflammatory responses in psoriasis.Methods EVs, derived from annexin A1 (ANXA1) overexpressing T cells, were co-extruded with M2 macrophage membrane to obtain EVs. In vitro, the effect of EVs on polarization was evaluated by real-time PCR. imiquimod (IMQ)-induced psoriasis-like mouse model, efficacy psoriatic inflammation Psoriasis Area and Severity Index (PASI) score...
Abstract Background Psoriasis is a chronic inflammatory skin disease with metabolic abnormalities serving as important contributors for pathogenesis and progression. Polyunsaturated fatty acids (PUFAs) have been found to be associated human diseases, including psoriasis. However, differences controversies exist regarding their content roles. Methods Plasma PUFAs concentrations were measured in 296 patients moderate-to-severe plaque psoriasis from the Shanghai Effectiveness Evaluation CoHort....
Disrupted N 6 -methyladenosine (m A) modification modulates various inflammatory disorders. However, the role of m A in regulating cutaneous inflammation remains elusive. Here, we reveal that and its methyltransferase METTL3 are down-regulated keratinocytes skin diseases. Inducible deletion Mettl3 murine results spontaneous increases susceptibility to with activation neutrophil recruitment. Therapeutically, restoration alleviates disease phenotypes mice suppresses human biopsy specimens. We...