A5028955861- Psoriasis: Treatment and Pathogenesis
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Hippo pathway signaling and YAP/TAZ
- melanin and skin pigmentation
- Retinoids in leukemia and cellular processes
- Biochemical Analysis and Sensing Techniques
- Autoimmune Bullous Skin Diseases
- Cancer survivorship and care
- Cancer Genomics and Diagnostics
- Heat shock proteins research
- Autoimmune and Inflammatory Disorders
- Cancer-related cognitive impairment studies
- Olfactory and Sensory Function Studies
- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Acne and Rosacea Treatments and Effects
- Melanoma and MAPK Pathways
- Skin Protection and Aging
- RNA Research and Splicing
- Childhood Cancer Survivors' Quality of Life
- Monoclonal and Polyclonal Antibodies Research
Soochow University
2015-2025
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2023
Jiangnan University
2019-2020
Wuxi Fourth People's Hospital
2019-2020
Tongji University
2015-2018
Shanghai Tenth People's Hospital
2015-2018
First Affiliated Hospital of Soochow University
2015
Exercise is associated with favorable outcomes in cancer survivors. The purpose of this meta-analysis to comprehensively summarize the effects exercise intervention breast survivors.A systematic search PubMed, Elsevier, and Google scholar was conducted up March 2015. References from relevant meta-analyses reviews were also checked.Thirty-three randomized controlled trials included meta-analysis, including 2,659 Compared control group, quality life significantly improved especially mental...
Objectives To Investigate the association between systemic inflammatory indicators and psoriasis in adult population of United States. Methods We analyzed data from 16,575 participants National Health Nutrition Examination Survey (NHANES) conducted years 2003-2004 2009-2014. employed multivariable logistic regression nonlinear curve fitting methods, which allowed us to evaluate associations inflammation such as NPAR, NLR, NHR, LHR, PHR, MHR. Furthermore, subgroup analyses were performed...
Psoriasis is an immune-mediated chronic inflammatory skin disease. As our understanding of the pathogenesis psoriasis has improved, biologic agents have become increasingly important in treatment psoriasis. However, use associated with cutaneous side effects. A new type effect called paradoxical reactions emerging threat arising from increasing agents.Here, we present a case - pyoderma gangrenosum (PG) and eczema induced by therapy. The was successfully eventually treated baricitinib.PG rare...
Abstract YAP is a critical protein in cancer development and can induce transformative phenotypes mammary epithelial cells. Previous studies have provided evidence that contribute to the metastatic behavior of melanoma, since specific knockdown leads reduced invasive capacity vitro . However, mechanism by which regulates function melanoma unknown. Here, we identified has positive impact on expression LRP1, also plays roles cancer. Mechanically, resulted significant down-regulation LRP1 at...
Phototherapy is an important method to treat vitiligo. However, it unclear how phototherapy affects melanocyte precursors and skin neural crest stem cells.To investigate the underlying mechanisms of narrow-band ultraviolet B (NB-UVB) induced lineage differentiated from human scalp-derived cells (HS-NCSCs).HS-NCSCs were expanded scalp hair follicles. The c-Kit-/CD57- HS-NCSCs isolated by cell sorting. Different doses NB-UVB used irradiate these HS-NCSCs. Cell ultrastructure was examined...
Paired box 2 gene promoted the progression of subsequent epithelial-mesenchymal transition (EMT) in malignant melanoma, which is most dangerous type skin cancer. We aimed to investigate functional role miR-204-3p metastatic melanoma.To study effects overexpressed on melanoma cells, mimic vector were transfected into A-375 cells for detecting cell viability using CCK-8 kit. Wound healing and Transwell assays performed assess migration invasion capacities cells. TargetScan miRTarBase used...
Background: Paired box 2 gene promoted the progression of subsequent epithelial-mesenchymal transition (EMT) in malignant melanoma, which is most dangerous type skin cancer. We aimed to investigate functional role miR-204-3p metastatic melanoma. Methods: To study effects overexpressed on melanoma cells, mimic vector were transfected into A-375 cells for detecting cell viability using CCK-8 kit. Wound healing and Transwell assays performed assess migration invasion capacities cells....
Objective To investigate changes in expressions of activation antigens CD69 and HLA-DR CD3+ T lymphocytes peripheral blood skin lesions patients with psoriasis vulgaris. Methods Peripheral samples were obtained from 20 vulgaris healthy controls, specimens the 15 out 10 controls. Flow cytometry was performed to quantify cells, an immunohistochemical study measure expression specimens. Statistical analysis carried by a two-sample t-test Pearson correlation SPSS 19.0...
The pathogenesis of melanoma is related to genetic and environmental factors such as longterm exposure ultraviolet rays. Recent studies have shown that the occurrence development are mainly associated with changes in extracellular signalregulated protein kinase (ERK)pathway phosphatidylinositol 3-kinase (PI3K)/serine/threonine (AKT)/mammalian target rapamycin (mTOR) pathway, well genes BRAF, NRAS, GNAQ, GNA11, C-kit, AKT, etc. Melanoma an invasive cutaneous tumor, usually resistant...