A5048348520- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Flavonoids in Medical Research
- Neurological Disease Mechanisms and Treatments
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Phytochemistry and Biological Activities
- Phytochemistry and Bioactivity Studies
- Atherosclerosis and Cardiovascular Diseases
- Clusterin in disease pathology
- Inflammatory mediators and NSAID effects
- Traditional Chinese Medicine Analysis
- Biological and pharmacological studies of plants
- Neuroscience of respiration and sleep
- Phytochemical compounds biological activities
- Thermal Regulation in Medicine
- Synthesis and bioactivity of alkaloids
- TGF-β signaling in diseases
Shanghai University of Traditional Chinese Medicine
2016-2023
State Administration of Traditional Chinese Medicine of the People's Republic of China
2016-2023
Central China Normal University
2019
Blood‐retinal barrier (BRB) breakdown is a typical event in the early stage of diabetic retinopathy (DR). This study aims to elucidate protection erianin, natural compound isolated from Dendrobium chrysotoxum Lindl, against DR development. Erianin alleviated BRB and rescued reduced claudin1 occludin expression retinas streptozotocin‐induced mice. microglial activation, ERK1/2 phosphorylation, NF‐κB transcriptional elevated TNF‐α both vitro vivo. inhibitor U0126 abrogated activation...
Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication with high incidence in both advanced and developing countries. Children surviving from HIE often have severe long-term sequela including cerebral palsy, epilepsy, cognitive disabilities. The severity of infants tightly associated increased IL-1β expression astrocyte activation which was regulated by transient receptor potential vanilloid 1 (TRPV1), non-selective cation channel the TRP family.Neonatal hypoxic ischemia (HI)...
As the most aggressive breast cancer, triple-negative cancer (TNBC) is still incurable and very prone to metastasis. The transform growth factor β (TGF-β)-induced epithelial–mesenchymal transition (EMT) crucially involved in metastasis of TNBC. This study reported that a natural compound isotoosendanin (ITSN) reduced TNBC by inhibiting TGF-β-induced EMT formation invadopodia. ITSN can directly interact with TGF-β receptor type-1 (TGFβR1) abrogated kinase activity TGFβR1, thereby blocking...
To observe the attenuation of ethanol extract Herba Scutellaria barbata (SE) against diabetic retinopathy (DR) and its engaged mechanism.C57BL/6J mice were intraperitoneally injected with streptozotocin (STZ, 55 mg/kg) for 5 consecutive days to induce diabetes. The orally given SE (100, 200 1mo at after STZ injection. Blood-retinal barrier (BRB) breakdown was detected by using Evans blue permeation assay. Real-time polymerase chain reaction (RT-PCR), Western blot immunofluorescence staining...
To investigate the alleviation of scutellarein (SN) against inner blood-retinal-barrier (iBRB) dysfunction in microglia cells stimulated by hyperglycemia and to elucidate engaged mechanism.