A5100435590- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Natural product bioactivities and synthesis
- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
- RNA regulation and disease
- Cancer, Hypoxia, and Metabolism
- Fatty Acid Research and Health
- Natural Compounds in Disease Treatment
- Growth Hormone and Insulin-like Growth Factors
- Angiogenesis and VEGF in Cancer
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Cardiovascular Function and Risk Factors
- Cholesterol and Lipid Metabolism
- Cardiac Imaging and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Protease and Inhibitor Mechanisms
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cardiovascular Effects of Exercise
Guangxi Medical University
2023
The University of Texas MD Anderson Cancer Center
2022
Southern Medical University Shenzhen Hospital
2019-2022
Nanchang University
2017-2021
Third Hospital of Nanchang
2021
Third Affiliated Hospital of Nanchang University
2021
The First Affiliated Hospital, Sun Yat-sen University
2021
Sun Yat-sen University
2021
Huaian First People’s Hospital
2020
Heidelberg University
2020
ZFAS1 is one of cardiac-specific or cardiac-related lncRNAs. This study was to explore the functional involvement and its regulatory role in AMI. In this study, models AMI rat myocardial cell cultured under hypoxia were made. The expression miR-150 infarction tissue cardiac myocytes determined by quantitative real time PCR. on examined RNA pull down assay. effect viability analyzed MTT relative myocardium infracted zone border significantly upregulated at 1-48 h rats, but it downregulated 1...
Long intergenic non-protein coding RNA 665 (LINC00665) plays a vital role in the development of cancer. Its function hepatocellular carcinoma (HCC), however, remains largely unknown.The expressions LINC00665, miR-186-5p, and MAP4K3 were determined by qRT-PCR. Cell viability apoptosis evaluated MTT flow cytometry, respectively. Autophagic puncta formation was observed fluorescence microscopy. Bioinformatics analysis, luciferase reporter assay, immunoprecipitation, pulldown performed to...
Background: The therapy and prognosis of lung cancer are difficult because multiple genetic epigenetic alterations. Long non-coding RNAs (lncRNAs) have been verified as new mediators development progression by virtue their various functions. Here, we focused on the lncRNA XLOC_008466 based previous microarray data. However, whether aberrant expression in human non-small cell (NSCLC) is correlated with malignancy, metastasis or has not elucidated. Methods: We performed real-time PCR, CCK-8,...
Various polyunsaturated fatty acids, especially gamma-linolenic acid (GLA), inhibit the growth of a variety tumor cells. Some evidence indicates that can kill cells by apoptosis. In current study, we tested apoptotic effect GLA on human chronic myelogenous leukemia K562 induced cell death in dose-dependent manner. Typical nuclei were shown staining with DNA-binding fluorochrome Hoechst 33342, characterized chromatin condensation and nuclear fragmentation. Flow cytometric analysis also...
Abstract Gastric cancer, is the fourth most common tumour type yet, ranks second in terms of prevalence cancer‐related deaths worldwide. CXXC finger protein 4 (CXXC4) has been considered as a novel cancer suppressive factor, including gastric cancer. This study attempted to investigate possible function CXXC4 and underlying mechanism. The binding ETS domain‐containing protein‐1 (ELK1) long non‐coding RNA MIR100HG promoter region was identified. Then, their expression patterns tissues cells...
Abstract Pseudogene pituitary tumor-transforming 3 (PTTG3P) is emerging as a key player in the development and progression of cancer. However, biological role clinical significance PTTG3P pancreatic ductal adenocarcinoma (PDAC) remain unclear. Here, we found that was significantly upregulated PDAC tissues. Elevated expression correlated with larger tumor size worse differentiation, reduced overall survival. Bioinformatics experimental evidence revealed promoted malignant phenotypes FoxM1...
The extract of Celastrus orbiculatus (COE) have been studied for anti-Helicobacter pylori (H. pylori) activity and anti-cancer effects in vitro vivo. However, the molecular mechanism by which COE inhibits H. pylori-induced inflammatory response has not fully elucidated so far.
Radiotherapy is the main treatment for localized prostate cancer. The therapeutic effects of radiotherapy are highly dependent on radiosensitivity target tumors. Here, we investigated impact insulin-like growth factor-binding protein 5 (IGFBP5) irradiation therapy in cancer.IGFBP5 gene was overexpressed human cancer cell lines, PC3 and DU145, with transfection lentivirus expression vector. Radiosensitivity lines assessed colony formation, cycle proliferation assays. proteins associated...
Long non-coding (lnc)RNA MIR17HG has been identified as a oncogene whose roles in acute myeloid leukemia (AML) remain unclear. The present study aimed to investigate the role of lncRNA AML. Differential expression AML was determined by reverse transcription-quantitative PCR. Overexpression assays and dual luciferase reporter were performed determine relationship between microRNA (miR)-21, apoptosis analyzed using an assay. results showed that decreased AML, which further following...
The aim of the present study was to determine competitive endogenous RNA (ceRNA) network associated with long‑coding (lncRNA) LA16c‑313D11.11 in endometrial cancer (EC). Initially, expression levels 60 EC tissues, 20 atypical hyperplasia endometrium (EAH) tissues and normal determined. MicroRNA (miRNA/miR)‑205‑5p mimics were transfected into HEC‑1A Ishikawa cells. miR‑205‑5p, their target proteins assessed using reverse transcription‑quantitative PCR or western blot analysis. Flow cytometry,...
HOX transcript antisense intergenic RNA (HOTAIR) is a lncRNA with length of 2,158 nucleotides and its two terminal domains could combine different complexes to function at the level transcription translation.It overexpresses in many cancers including gastric cancer.HOTAIR play an oncogenic role initiation progression cancer through interaction microRNAs, such as miR-330/618/126 PI3K/Akt signaling pathways.HOTAIR single nucleotide polymorphisms (SNPs) may have genotype-function...
Echocardiographic global myocardial work (GMW) indices recently emerged to non-invasively evaluate left ventricular (LV) performance with less load-dependence than LV ejection fraction (LVEF) or longitudinal strain (GLS). Yet, few data exist on the descriptions of GMW in young people. We therefore aimed provide normal reference values a healthy cohort, and simultaneously investigate factors associated non-invasive indices.A total 155 people (age 10-24 years, 59% male) underwent transthoracic...
Abstract Bone metastasis is a frequent complication of breast cancer, occurring in about 50-70% cancer patients with late-stage disease. The lack effective therapy suggests that the precise molecular mechanisms underlying bone are still unclear. Enhancer zeste homolog 2 (EZH2) considered oncogene and its expression correlated but function has not been well explored. Herein we report EZH2 promotes osteolytic through regulating transforming growth factor beta (TGFβ) signaling, key pathway...