A5100400613- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Immunodeficiency and Autoimmune Disorders
- RNA modifications and cancer
- Supercapacitor Materials and Fabrication
- Genomics, phytochemicals, and oxidative stress
- Metabolism, Diabetes, and Cancer
- Natural Compounds in Disease Treatment
- Immune Response and Inflammation
- Mycobacterium research and diagnosis
- Gastrointestinal disorders and treatments
- IgG4-Related and Inflammatory Diseases
- Advanced Battery Materials and Technologies
- Renal cell carcinoma treatment
- RNA Research and Splicing
- Erythrocyte Function and Pathophysiology
- FOXO transcription factor regulation
- Viral-associated cancers and disorders
- Advancements in Battery Materials
- Renal and related cancers
- Inflammatory Myopathies and Dermatomyositis
- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
Tianjin Medical University General Hospital
2019-2024
Sichuan University
2022
West China Hospital of Sichuan University
2022
82th Hospital of Pla
2021
Guangzhou Medical University
2008
The aim of this study is to profile the transcriptional landscapes affected tissues and peripheral blood mononuclear cells (PBMCs) at single-cell level in IgG4-related disease (IgG4-RD). Identifying cell populations crosstalk between immune non-immune will assist us understanding aetiology IgG4-RD.We performed RNA sequencing analysis on submandibular glands (SMGs) PBMCs from patients with IgG4-RD matched controls. Additionally, bulk was used construct repertoire. Furthermore, multiplex...
Abstract Background Rheumatoid arthritis (RA) is a systemic and chronic inflammatory disease. The cellular glucose metabolism of fibroblast‐like synoviocytes (FLSs) RA has been revealed to be essential the pathogenesis development RA. To date, precise roles molecular mechanisms long noncoding RNA TUG1 in have not elucidated. Methods miR‐34a‐5p were detected by qRT‐PCR. Interactions between lncRNA‐miRNA miRNA‐mRNA validated pull‐down assay luciferase assay. was evaluated uptake extracellular...
Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease; cellular glutamine metabolism in fibroblast-like synoviocytes (FLSs) of RA was known to be essential for pathogenesis and progression. NEAT1, long non-coding RNA, functions as an oncogene diverse cancers. The exact roles molecular mechanisms NEAT1 patients are unknown.Expression miR-338-3p measured by qRT-PCR. lncRNA-miRNA miRNA-mRNA interactions were predicted from starBase validated RNA pull-down luciferase assay. FLSs...
The extract of Celastrus orbiculatus (COE) have been studied for anti-Helicobacter pylori (H. pylori) activity and anti-cancer effects in vitro vivo. However, the molecular mechanism by which COE inhibits H. pylori-induced inflammatory response has not fully elucidated so far.
The role of GAS6 antisense RNA 1 (GAS6‑AS1) in clear cell renal carcinoma (ccRCC) remains unclear. aim the present study was to investigate and molecular mechanisms GAS6‑AS1 progression ccRCC. found be upregulated ccRCC tissues lines, patients with high expression levels exhibited a poor prognosis. Small interfering (si)RNA inhibited activity, colony formation, invasiveness glycolysis OSRC‑2 SW839 cells, while overexpression promoted these functions. Moreover, si‑GAS6‑AS1 increased...
1. Cytoprotection by H(2)O(2) preconditioning against oxidative stress-induced apoptosis of PC12 cells has been demonstrated previously. In the present study, we investigated effects on nuclear factor (NF)-kappaB activation and role NF-kappaB in adaptive cytoprotection cells. 2. The were preconditioned with 100 micromol/L for 90 min, followed 24 h recovery subsequent exposure to 300 a further 12 h. 3. results showed that upregulated expression enhanced its translocation DNA binding activity....
The objective of this study was to profile the transcriptional profiles peripheral blood mononuclear cells (PBMCs) and their immune repertoires affected by anti-synthetase syndrome (ASS) at single-cell level.