A5035164138- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- COVID-19 and Mental Health
- Cardiac Arrest and Resuscitation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Sulfur-Based Synthesis Techniques
- COVID-19 epidemiological studies
- Vitamin C and Antioxidants Research
- Kawasaki Disease and Coronary Complications
- Immune Response and Inflammation
- MicroRNA in disease regulation
- COVID-19 and healthcare impacts
- Congenital Diaphragmatic Hernia Studies
- Synthesis of heterocyclic compounds
- Platelet Disorders and Treatments
- Pediatric health and respiratory diseases
- Birth, Development, and Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
Xinjiang Medical University
2025
Chinese PLA General Hospital
2020-2024
Shanghai Changzheng Hospital
2023-2024
First People's Hospital of Yunnan Province
2024
Dalian Medical University
2020-2022
Chongqing Medical University
2020-2022
Second Affiliated Hospital of Chongqing Medical University
2020-2022
National Medical Products Administration
2020-2021
People's Liberation Army 401 Hospital
2020
Wuhan University
2017-2020
The global death toll from coronavirus disease (COVID-19) virus as of May 12, 2020, exceeds 286,000. risk factors for were attributed to advanced age and comorbidities but have not been accurately defined.
The coronavirus disease 2019 (COVID-19) triggered by severe acute respiratory syndrome 2 (SARS-CoV-2) erupted in Hubei Province of China December and has become a pandemic. Severe COVID-19 patients who suffer from distress (ARDS) multi-organ dysfunction have high mortality. Several studies shown that this is closely related to the cytokine release (CRS), often loosely referred as storm. IL-6 one key factors its level positively correlated with severity disease. molecular mechanisms for CRS...
Abstract Background In January 19, 2020, first case of 2019 novel coronavirus (2019-nCoV) pneumonia (COVID-19) was confirmed in Chongqing municipality, China. Methods this retrospective, descriptive, multiple-center study, total 267 patients with COVID-19 by real-time RT-PCR from Jan 19 to Feb 16, 2020 were recruited. Epidemiological, demographic, clinical, radiological characteristics, laboratory examinations, and treatment regimens collected on admission. Clinical outcomes followed up...
At present, there is insufficient evidence to evaluate the prognosis of patients with sepsis. This study anazed clinical data 822 sepsis in ICU a tertiary Grade A hospital construct and validate nomogram model for predicting 28-day mortality risk patients. The was constructed using multivariate logistic regression analysis screen independent factors affecting prognosis, prediction built based on these factors. performance evaluated Hosmer–Lemeshow test, receiver operating characteristic...
Abstract Background The outbreak of COVID-19 has aroused global concerns. We aimed to describe the clinical characteristics nonsurvivors and analyze possible causes for rapid disease progress death. Methods Patients with confirmed died in Renmin Hospital Wuhan University before February 15, 2020, were identified. obtained epidemiological, demographic, data from electronic medical records. Results Among 101 nonsurvivors, median age was 71.0 years (IQR, 59.0-80.0), 59.4% male, 79.2% had one or...
Abstract Sepsis is a severe clinical disease, which resulted from the excessive host inflammation response to infection. Growing evidence indicates that Staphylococcus aureus pneumonia significant cause of sepsis, can lead intestinal injury, inflammation, and apoptosis. Studies have shown miR‐182‐5p serve as tumor oncogene or suppressive microRNA in various cancers, however, its biological role sepsis still uninvestigated. Here, we reported was obviously increased S. mice models. Loss...
Abstract Background Asthma is widely recognized as an inflammatory disorder. In the context of this microenvironment, involvement hypoxia and its impact on related pathways have drawn considerable attention. However, exact role hypoxia, a prevalent environmental factor, in development progression asthma remains poorly understood. Methods Mice were treated with house dust mite (HDM) extracts for 23 days to induce asthma. divided into room air (RA) group intermittent hypoxic (IH) by exposing...
Sepsis and intestinal injury triggered by sepsis are common in intensive care units, which can contribute to a high mortality. lncRNAs modulate gene expression, they closely involved multiple diseases, including sepsis. In our present study, we investigated the biological function of MEG3 sepsis, especially during injury. Currently, observed that LPS-induced mouse models, was triggered. Meanwhile, reported greatly decreased vivo, with an increase miR-129-5p inhibition SP-D. Then,...
Patients with severe or critical COVID-19 are at higher risk for developing acute kidney injury (AKI). However, whether AKI is diagnosed in all the patients and correlation between outcomes of not well understood.
Coronavirus disease-2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread globally since its first report and become a worldwide pandemic. In response to outbreak of COVID-19, Center for Medical Device Evaluation, NMPA (CMDE) initiated emergency review approval procedures accelerate process reviewing emergent medical products issued Key Points Technical Review Registration SARS-CoV-2 Antigen/Antibody Tests (Key Points) provide...
This study aims to investigate the role of Sirt5 in regulating eosinophil maturation and activation, specifically focusing on primary eosinophils mice at genetic level. Additionally, elucidate underlying mechanism eosinophilic inflammation metabolism identify potential drug targets for treatment chronic sinusitis. The findings this will provide new insights a solid theoretical basis development novel therapeutic strategies rhinosinusitis (eCRS). Our investigated gene expression both non-eCRS...
Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 antibody testing an important supplement to nucleic acid testing. In the process of emergency approval, Center for Medical Device Evaluation China National Products Administration released Key Points Technical Review Registration Antigen/Antibody Detection Reagents. Clinical Study Requirement section Point has put forward requirements in terms reference methods...