A5018030955- Probiotics and Fermented Foods
- Gut microbiota and health
- Protein Hydrolysis and Bioactive Peptides
- Helicobacter pylori-related gastroenterology studies
- Food Allergy and Anaphylaxis Research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Microbial Metabolites in Food Biotechnology
- Gout, Hyperuricemia, Uric Acid
- Traditional and Medicinal Uses of Annonaceae
- Proteins in Food Systems
- Glutathione Transferases and Polymorphisms
- Phytochemical and Pharmacological Studies
- Herpesvirus Infections and Treatments
- Allergic Rhinitis and Sensitization
- Synthesis and biological activity
- Genomics, phytochemicals, and oxidative stress
- Herbal Medicine Research Studies
- Free Radicals and Antioxidants
- Veterinary medicine and infectious diseases
- Liver physiology and pathology
- Viral gastroenteritis research and epidemiology
- Barrier Structure and Function Studies
- Galectins and Cancer Biology
- Inflammatory Bowel Disease
National Institute of Technology, Miyakonojo College
2020
Shinshu University
1992-1995
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease such as hepatitis, cirrhosis, and hepatocellular carcinoma. While searching for new natural anti-HCV agents in agricultural products, we found potent inhibitor HCV RNA expression extracts blueberry leaves when examined an subgenomic replicon cell culture system. This activity was observed methanol extract fraction purified by repeated fractionations reversed-phase high-performance liquid chromatography. The final...
The aims of this study were to investigate the diversity lactic acid bacteria (LAB) isolated from traditional Mongolian dairy products, and estimate probiotic potential strains. We collected 66 samples products tarag (n = 45), airag 7), aaruul 8), byasulag 1) eezgii 5), which 543 LAB strains identified based on 16S ribosomal DNA sequence. predominant species those Lactobacillus (L.) delbrueckii ssp. bulgaricus, L. helveticus, fermentum, lactis Lactococcus lactis. However, we could not detect...
We investigated 10 lactic acid bacteria strains with probiotic potential prepared from Mongolian dairy products for their ability to induce T helper type-1 (Th1) cytokine production in mouse immune cells vitro and vivo. Among these strains, the Lactobacillus plantarum 06CC2 strain was effective elevating level of interleukin (IL)-12p40 co-culture J774.1 levels IL-12 interferon (IFN)-γ spleen vitro. Oral administration this augmented gene expression IFN-γ IL-12p40 enlarged population CD4(+),...
Dysbiosis of the enteric microbiota causes gastrointestinal diseases, including colitis. The present study investigated beneficial effect Lactobacillus plantarum 06CC2 in experimental colitis mice. An model C57BL6 mice was induced using dextran sulfate sodium. Mice were orally administered (06CC2 group) or PBS only (control by gavage. disease activity index (DAI), histological grading, and colon tissue colonic lamina propria mononuclear cells (LPMCs) examined macroscopically...
ATP-binding cassette transporter subfamily G member 2 (ABCG2) is responsible for the excretion of foreign substances, such as uric acid (UA) and indoxyl sulfate (IS), from body. Given importance increased ABCG2 expression in UA excretion, we investigated enhancement intestinal using
Previous study suggested that dietary intake of Lactobacillus plantarum 06CC2 (LP06CC2) isolated from Mongolian dairy products showed various health beneficial effects. Here, the effect LP06CC2 on cholesterol metabolism in mice fed a cholesterol-loaded diet was evaluated. Cholesterol and were incorporated into AIN93G-based to evaluate Balb/c mice. Serum liver levels significantly increased whereas ingestion suppressed increase cholesterol. hepatic damage indices. The cecal content fecal...
Aim: Hepatic stellate cell (HSC) proliferation plays a pivotal role in liver fibrogenesis, and agents that suppress HSC activation, including platelet‐derived growth factor (PDGF)‐induced proliferation, are good candidates for antifibrogenic therapies. In this report, we use the LI90 line to elucidate effects of proanthocyanidin derived from leaves Vaccinium virgatum . Methods: Proanthocyanidin (PAC) was extracted blueberry V. (BB‐PAC), grape seeds (GS‐PAC) Croton lechleri (CL‐PAC). These...
We screened suitable lactic acid bacteria (LAB) strains for use in fermented dairy products by analyzing milk with 10 probiotic LAB from Mongolian products. Lactobacillus paracasei strain 06TCa19 was selected because of its favorable effects on pH, production, and viable bacterial numbers after fermentation skim milk. Then, we prepared control milks conducted a randomized, double-blind crossover study 46 healthy women to determine the human defecation. The ingestion improved subjects’ fecal...
Fewer studies on the effects of heat treatment casein under acidic conditions have been reported compared with those neutral conditions. This study aims to clarify effect properties and functions milk proteins. The turbidity reconstituted skimmed increased increasing temperature (70 – 90°C) pH (3.40 3.55). Suspensions heated samples were stable did not sediment at low-speed centrifugation. Mean particle diameters heat-induced particles 200 680 nm. Sodium dodecyl sulfate–polyacrylamide gel...
Helicobacter (H.) pylori is known to be a bacterial risk factor for gastric cancer. In this study, 16 strains of lactic acid bacteria (LAB) isolated from Mongolian dairy products were screened potential probiotic activity against H. strain no. 130 in vitro. Lactobacillus (L.) paracasei 06TCa19 and L. plantarum 07MR044 identified as LAB with anti-H. activities. Compared 07MR044, was more potent reducing counts co-culture. The ability inhibit the growth attributable its rapid excessive...
The effects of
In order to find new antiasthmatic agents with dual antagonistic activity against thromboxane A2 (TXA2) and leukotriene D4 (LTD4) receptors, synthesis pharmacological evaluation of various [4-[1-(benzenesulfonamido)-alkyl]phenyl]alkanoic acid derivatives were undertaken. TXA2 LTD4 activities in vitro evaluated by measuring the inhibitory effects on L-46619-induced contraction guinea-pig trachea LTD4-induced ileum trachea. Several compounds showed satisfactory activities, their effect (after...
2-(2-Hydroxyalkylidene)cyclopentanones (1) and 5-(2-hydroxyoctylidene)-2-cyclopentenone (2) were synthesized by the aldol reaction of cyclopentanone-enolate (3)/cyclopentenone-enolate (19) with 2-bromoalkanals (4)/2-bromooctanal (4c) subsequent treatment products sodium acetate. The stereochemistry condensation, substitution elimination was elucidated. bio-antimutagenic activity 1 increased as 2-hydroxyalkylidene group in length up to = CHCH(OH)C8H17.