A5025682247- Respiratory viral infections research
- Pharmacy and Medical Practices
- Pharmaceutical Practices and Patient Outcomes
- Safe Handling of Antineoplastic Drugs
- Adipokines, Inflammation, and Metabolic Diseases
- Neonatal Respiratory Health Research
- Bee Products Chemical Analysis
- Infant Nutrition and Health
- Essential Oils and Antimicrobial Activity
- Immune Response and Inflammation
- Pediatric health and respiratory diseases
- Probiotics and Fermented Foods
- Air Quality and Health Impacts
- Mangiferin and Mango Extracts
- Pesticide Exposure and Toxicity
- Insect and Pesticide Research
- Phytochemicals and Antioxidant Activities
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Bioactive natural compounds
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Per- and polyfluoroalkyl substances research
- Pneumonia and Respiratory Infections
- NF-κB Signaling Pathways
Clover Seed (China)
2024
Kyushu University of Health and Welfare
2013-2023
Saga Medical School Hospital
2013
Nihon University
2009-2010
University of Miyazaki Hospital
2008
University of Rochester Medical Center
2007
University of Southern California
2005
Toll-like receptor 2 (TLR2) plays an important role in host defense against bacterial pathogens. Activation of TLR2 signaling not only induces the activation innate immunity and instructs development acquired but also leads to detrimental inflammatory responses infectious diseases. To avoid responses, must be tightly regulated. In contrast relative known positive regulation signaling, its negative regulation, however, is largely unknown. addition distal components that link downstream...
Ethanol extracts (AF-06, 07, and 08, 10 mg/kg) of Brazilian propolis were administered orally to cutaneously herpes simplex virus type 1 (HSV-1)-infected mice three times daily on days 0 6 after infection evaluate their efficacies against HSV-1 significantly limited development herpetic skin lesions. AF-07 08 reduced titers in brain and/or day 4 without toxicity, but AF-08 had no anti-HSV-1 activity vitro. AF-06 enhanced delayed-type hypersensitivity (DTH) inactivated antigen infected mice....
Moringa oleifera Lam. is used as a nutritive vegetable and spice. Its ethanol extract has been previously shown to be significantly effective in alleviating herpetic skin lesions mice. In this study, we evaluated the alleviation by aqueous (AqMOL) assessed mode of its anti-herpetic action murine cutaneous herpes simplex virus type 1 (HSV-1) infection model. AqMOL (300 mg/kg) was administered orally HSV-1-infected mice three times daily on days 0 5 after infection. limited development reduced...
To investigate the effects of lactoferrin (LF) on infectious diseases in Japanese summer.An intake placebo, 200 mg, or 600 mg LF were administered to healthy adults Kyushu University Health and Welfare for 12 weeks a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The primary endpoints prevalence duration changes immune parameters.Three hundred ten subjects randomized (placebo, n = 104; 103; 103). Twenty lost follow-up, leaving 290 full analysis set (n 99;...
We investigated 10 lactic acid bacteria strains with probiotic potential prepared from Mongolian dairy products for their ability to induce T helper type-1 (Th1) cytokine production in mouse immune cells vitro and vivo. Among these strains, the Lactobacillus plantarum 06CC2 strain was effective elevating level of interleukin (IL)-12p40 co-culture J774.1 levels IL-12 interferon (IFN)-γ spleen vitro. Oral administration this augmented gene expression IFN-γ IL-12p40 enlarged population CD4(+),...
Tetrabromobisphenol A (TBBPA), a brominated flame retardant, has been found to exacerbate pneumonia in respiratory syncytial virus- (RSV-) infected mice. We examined the effect of Brazilian propolis (AF-08) on exacerbation RSV infection by TBBPA exposure Mice were fed powdered diet mixed with 1% alone, 0.02% AF-08 or and for four weeks then intranasally RSV. increased pulmonary virus titer level IFN- γ , representative marker due infection, lungs mice without toxicity. was significantly...
Clinical pharmacy training III (bedside training) in the School of Pharmaceutical Sciences, Kyushu University Health and Welfare is intended to train pharmacists who can also cope with medical emergencies. Therefore we produced original scenarios that provide experience various emergencies using emergency care simulators. As a result, these simulators enabled students dealing such as cardiopulmonary resuscitation, automated external defibrillation (AED), adrenalin administration, oxygen...
Methamidophos, a representative organophosphate insecticide, is regulated because of its severe neurotoxicity, but it suspected contaminating agricultural foods in many countries due to illicit use. To reveal unknown effects methamidophos on human health, we evaluated the developmental immunotoxicity using respiratory syncytial virus (RSV) infection mouse model. Pregnant mice were exposed (10 or 20 ppm) their drinking water from gestation day 10 weaning postnatal 21. Offsprings born these...
To investigate the effects of perinatal exposure to tetrabromobisphenol A (TBBPA), a brominated flame retardant, on immune system, respiratory syncytial virus (RSV) infection mouse model was utilized. Female mice were exposed TBBPA mixed with diet from 10 days after conception weaning postnatal day 21. Offspring infected intranasally A2 strain RSV. Although no general toxicological sign observed, pulmonary viral titers offspring 0.1% significantly increased compared control 5 post-infection....
Glucosyl hesperidin (GH) is a water-soluble derivative of hesperidin, citrus flavonoid. GH has various pharmacological effects, such as hypolipidemic and hypouricemic may therefore be useful supplement or drug. In the present study, we evaluated effects long- short-term intake on hyperglycemia macrophage infiltration into adipose tissue high-fat diet (HFD)-fed mice. Long-term (11-week) consumption tended to reduce body weight fasting blood glucose concentration HFD-fed mice, ameliorated...