A5103192673- Infant Nutrition and Health
- Phytochemistry and biological activity of medicinal plants
- Gut microbiota and health
- Nutritional Studies and Diet
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Skin Protection and Aging
- Advanced Electron Microscopy Techniques and Applications
- Electron and X-Ray Spectroscopy Techniques
- Oral microbiology and periodontitis research
- Neonatal Respiratory Health Research
- Viral gastroenteritis research and epidemiology
- Lipid metabolism and disorders
- Protein Hydrolysis and Bioactive Peptides
- Vestibular and auditory disorders
- Infant Development and Preterm Care
- Neuropeptides and Animal Physiology
- melanin and skin pigmentation
- Hypothalamic control of reproductive hormones
- Dental Radiography and Imaging
- Bone Tissue Engineering Materials
- dental development and anomalies
- Child Nutrition and Feeding Issues
- Clinical Nutrition and Gastroenterology
- Regulation of Appetite and Obesity
Tohoku University
2012-2025
Megmilk Snow Brand (Japan)
2016-2025
Innovative Research (United States)
2025
Morinaga (Japan)
2008-2024
Food Research and Development Institute
2012-2023
Toyo Institute of Food Technology
2015-2020
Aichi Gakuin University
2012-2020
Fraunhofer USA
2020
Musashino Red Cross Hospital
2019-2020
Shinshu University
2020
<b><i>Background/Aims:</i></b> Our previous study confirmed that <i>Aloe</i> sterol stimulates collagen and hyaluronic acid production in human dermal fibroblasts. This aims to investigate whether intake affects skin conditions. <b><i>Methods:</i></b> We performed a 12-week, randomized, double-blind, placebo-controlled evaluate the effects of oral supplementation on elasticity, hydration, score 64 healthy women (age range 30-59...
We investigated the effects of oral administration lophenol (Lo) and cycloartanol (Cy), two kinds antidiabetic phytosterol isolated from Aloe vera , on glucose lipid metabolism in Zucker diabetic fatty (ZDF) rats. demonstrated that administrations Lo Cy suppressed random fasting levels reduced visceral fat weights significantly. It was also observed treatments with decreased serum hepatic concentrations (triglyceride, nonesterified acid, total cholesterol). Additionally, resulted a tendency...
Accumulating evidence suggests a relationship between the gut microbiota and development of obesity, indicating potential probiotics as therapeutic approach. Bifidobacterium breve B-3 has been shown to exert anti-obesity effects in high-fat diet-induced obese mice. In present study, consumption B. by healthy pre-obese (25 ≤ BMI < 30) adults were investigated randomized, double-blind, placebo-controlled trial (trial registration: UMIN-CTR No. 000023919; preregistered on September 2, 2016)....
Indole in the gut is formed from dietary tryptophan by a bacterial tryptophan-indole lyase. not only triggers biofilm formation and antibiotic resistance microbes but also contributes to progression of kidney dysfunction after absorption intestine sulfation liver. As an essential amino acid for humans, these events seem inevitable. Despite this, we show proof-of-concept study that exogenous indole can be converted immunomodulatory metabolite, indole-3-lactic (ILA), previously unknown...
Background: Aloe is known for its topical use treating wounds and burns. Many previous studies reported the healing effects of vera . However, there are few clinical on effect orally administered A. gel skin. sterols a type plant that have capability to regulate metabolism glucose lipids. In recent study, we confirmed ingested reached peripheral tissues through bloodstream. their influence dermal fibroblasts has not been investigated. Methods: First, investigated (cycloartenol lophenol)...
Human noroviruses cause significant morbidity and mortality worldwide, but lack approved antivirals or vaccines to treat prevent infections. The recent development of two cell culture systems in human transformed B cells (BJABs) non-transformed intestinal enteroid cultures overcomes a main limitation identifying molecules with anti-norovirus activities. Lactoferrin is an iron-binding glycoprotein found the milk most mammals, broad spectrum antimicrobial activities, including against related...
Visceral fat accumulation is considered to be associated with a higher risk of chronic diseases. We investigated the effects Bifidobacterium longum subsp. (B. longum) BB536 and breve breve) MCC1274 on body composition, including visceral fat, in randomized, parallel-group, placebo-controlled study. Participants were between 29 64 years age had mass index (BMI) greater than 23 less 30. One hundred participants randomly assigned probiotics group or placebo group. administered probiotic...
Summary Background Aloe vera is a traditional medical plant whose gel has been widely used in skin care. Previously, we have identified sterols from as active ingredients. This study investigated the protective effects of without polysaccharides, against ultraviolet B ( UVB )‐induced photoaging mice using extract AVGE ) obtained by supercritical fluid extraction. Methods was supplemented diet (12 or 120 ppm), and HR ‐1 hairless were exposed to irradiation for 7 weeks. Skin measurements...
Abstract Understanding the viability of ingested probiotics within gastrointestinal tract is essential for evaluating their efficacy and deciphering mechanisms action. Detecting Bifidobacterium longum subspecies BB536 particularly challenging owing to its indistinguishability from naturally abundant B. species in human gut. We aimed address this challenge by developing a selective culture medium employing propidium monoazide-quantitative polymerase chain reaction (PMA-qPCR) method verify...
The aim of the present study was to investigate anti-obesity effects Aloe vera gel administration in male Sprague-Dawley (SD) rats with diet-induced obesity (DIO). SD at 7 wk age were fed either a standard diet (10 kcal% fat) (StdD) or high-fat (60 (HFD) during experimental period. Four weeks after HFD-feeding, DIO (11 age) orally administered two doses powder (20 and 200 mg/kg/d) for 90 d. Body weights (g) body fat (%) HFD significantly higher than those StdD-fed rats. Although modest...
Objective: We investigated the effects of lactoferrin (LF)-fortified formula on acute gastrointestinal and respiratory symptoms in children. Design: Randomized, double-blind, placebo-controlled trial. Setting subjects: Children aged 12-32 months Japan. Intervention: Intake placebo or LF (48 mg/day)-fortified for 13 weeks. Primary endpoint: Prevalence symptom. Results: One hundred nine participants were randomized. Eight lost to follow-up, withdrew consent, deemed inappropriate trial, with...
Previous clinical studies have shown that heat-killed Lacticaseibacillus paracasei MCC1849 suppresses subjective symptoms among healthy adults. However, the mechanism underlying this beneficial effect remains unclear. This study aimed to investigate effects of on immune functions in humans. In randomized, double-blind, placebo-controlled, parallel-group study, 100 adults were randomly divided into or placebo groups. Participants ingested test powder with 5 × 1010 cells for 4 weeks. Immune...
We evaluated the effect of Bifidobacterium lomgum BB536 (B. longum BB536) on subjective symptoms physical condition healthy adults in a double-blind, randomized, placebo-controlled trial. Two hundred participants were recruited and randomized into two groups (BB536 group: n = 100; placebo 100) based frequency with which they experienced cold during three years prior to study. The consumed either powder containing 1 × 1010 colony forming units (CFU) B. or once daily for 12 weeks, their health...
This study reports the effects of oral Aloe vera gel powder (AVGP) containing sterols on skin elasticity and extracellular matrix in ultraviolet B (UVB)-irradiated hairless mice. Ten-week-old mice were fed diets 0.3% AVGP for 8 weeks irradiated UVB 6 weeks. Mice treated with showed significant prevention UVB-induced decrease elasticity. To investigate mechanism underlying this suppression loss, we measured expression metalloproteinase (MMP)-2, -9, -13. prevented both increases MMPs...
To investigate the effects of lactoferrin (LF) on infectious diseases in Japanese summer.An intake placebo, 200 mg, or 600 mg LF were administered to healthy adults Kyushu University Health and Welfare for 12 weeks a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The primary endpoints prevalence duration changes immune parameters.Three hundred ten subjects randomized (placebo, n = 104; 103; 103). Twenty lost follow-up, leaving 290 full analysis set (n 99;...
Titanium (Ti) is an osteoconductive material that routinely used as a bulk implant to fix and restore bones teeth. This study explored the effective use of Ti bone engineering scaffold. Challenges overcome were: (1) difficult liquid/cell infiltration into microfiber scaffolds due hydrophobic nature Ti; (2) cell attachment on thin curved microfibers. A recent discovery UV-photofunctionalization prompted us examine its effect scaffolds. Scaffolds in disk form were made by weaving grade 4 pure...
We previously reported that the intake of heat-killed Lacticaseibacillus paracasei MCC1849 suppressed onset cold-like symptoms in healthy young women who were susceptible to colds. This study aimed investigate effects on subjective physical condition adults a wide age range. In this randomized, double-blind, placebo-controlled, parallel-group study, 200 randomly divided into group or placebo group. The participants received test powder with 50 billion cells without for 24 weeks. Subjective...
Poly(methyl methacrylate) (PMMA)-based bone cement, which is widely used to affix orthopedic metallic implants, considered bio-tolerant but lacks osteoconductivity and cytotoxic. Implant loosening toxic complications are significant recognized problems. Here we devised two strategies improve PMMA-based cement: (1) adding 4-methacryloyloxylethyl trimellitate anhydride (4-META) MMA monomer render it hydrophilic; (2) using tri-n-butyl borane (TBB) as a polymerization initiator instead of...