A5081645019- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Ear and Head Tumors
- Retinopathy of Prematurity Studies
- Cancer-related molecular mechanisms research
- Tumors and Oncological Cases
- Neuroendocrine Tumor Research Advances
- Head and Neck Anomalies
- Oral and Maxillofacial Pathology
- Cancer therapeutics and mechanisms
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Sarcoma Diagnosis and Treatment
- Meningioma and schwannoma management
- Nonmelanoma Skin Cancer Studies
- Management of metastatic bone disease
- Inflammatory mediators and NSAID effects
- Glaucoma and retinal disorders
- Soft tissue tumor case studies
- Oral health in cancer treatment
- Nerve Injury and Rehabilitation
Tokyo National Hospital
1994-2025
National Cancer Center
2020-2025
National Cancer Center Hospital East
2020-2025
Gunma Prefectural Cardiovascular Center
2023
Tokyo Medical and Dental University
2015-2021
Tokyo Metropolitan Komagome Hospital
2007-2020
Hyogo Prefectural Cancer Center
2016
Shikoku Cancer Center
2000-2007
Kitasato University
2007
Yokohama Municipal Citizen's Hospital
2007
1. An enzyme-linked immunosorbent assay (ELISA) using specific antisera has been developed to quantify individual cytochrome P450 (P450) enzymes (1A1/2, 2B11, 2C21 and 3A12) in dog liver microsomes.2. The contents of CYP1A1/2, 3A12 untreated male microsomes determined by the ELISA were 17, 48, 160 69 pmol/mg protein respectively, corresponding 4, 10, 34 15% total optically respectively. These female showed almost similar amounts relative proportions those observed microsomes.3. oral...
Introduction There is no established methodology for the perioperative management of head and neck cancer surgery free tissue transfer reconstruction (HNS-FTR). A single dose corticosteroid administered immediately before has been shown to reduce postoperative pain nausea/vomiting after some types surgery. However, efficacy this strategy not demonstrated in HNS-FTR, increased risk infectious complications associated with its use cannot be ruled out. This phase III, placebo-controlled,...
Key Clinical Message We present a case of parenchymatous glossitis with unilateral severe inflammation the hyoglossus muscle, resulting in laryngeal edema. The route was unique. Contrast‐enhanced CT useful for diagnosis. Administration sensitive antibiotics led to improvement. Creatine phosphokinase may be an indicator diagnosis and treatment response.
Abstract Background Magnifying endoscopy with narrowband imaging (ME‐NBI) is useful in predicting the invasion depth by examining microvascular status of tumor surfaces. This retrospective study aimed to determine its efficacy pharyngeal cancer. Methods Between April 2016 and March 2018, 59 lesions from 46 patients who underwent transoral resection were retrospectively analyzed. Using ME‐NBI, was classified into B1, B2, or B3, based on classification Japan Esophageal Society. Results A...
舌の外側に存在する舌リンパ節は，古典的分類では外側舌リンパ節と分類されてきた。しかしながら，近年古典的外側舌リンパ節に含まれない舌骨傍領域リンパ節が報告され，古典的分類は現在の臨床に対応できていない。臨床的対応と解剖を考慮した新しい舌リンパ節分類として，舌リンパ節を舌内(両側オトガイ舌筋間)の正中舌リンパ節，舌下間隙の前外側舌リンパ節，顎下間隙の後外側舌リンパ節，副咽頭間隙の舌骨傍舌リンパ節に区分する分類を提案した。当院で初回治療を行った舌癌100例中，舌リンパ節転移は舌の外側に存在する前外側舌リンパ節転移3例，後外側舌リンパ節転移1例，舌骨傍舌リンパ節転移4例の計8例(8%)に認めた。
7044 Background: Cisplatin (P) plus etoposide (E) with concurrent TRT is a standard treatment for limited stage (LD) SCLC. Irinotecan (I) an active agent SCLC and IP superior to PE in extensive We initially conducted randomized phase II study evaluate of followed by either or IPE LD-SCLC. However, the protocol was amended single-arm because unacceptable toxicity regimen. Purpose: To efficacy safety profile Methods: Eligibility criteria included untreated LD-SCLC, age ≤70, ECOG performance...
The upper esophageal sphincter plays a significant role by forming physical barrier at the junction of hypopharynx and cervical esophagus. As few studies have focused on ventral aspect this junction, contribution anterior wall esophagus to function remains unknown. purpose study was examine muscle fibers' arrangement especially those its wall. Thirteen specimens from 13 Japanese cadavers were analyzed. Six dissected macroscopically, while remaining seven examined histologically. outer...
7067 Background: ZD6474 is a once-daily oral therapy that selectively inhibits key signaling pathways in cancer by targeting vascular endothelial growth factor receptor (VEGFR)-dependent tumor angiogenesis, and epidermal (EGFR)- RET-dependent cell proliferation survival. was evaluated as monotherapy an ongoing randomized, double-blind, parallel-group, Phase IIa, dose-finding, multicenter study Japan. Methods: Patients with locally advanced or metastatic (stage IIIB/IV) recurrent...
Abstract Inconsistency in the definition of LLNs may be a hurdle ensuring accuracy evidence. Refinements classification LLNs, based on fascial anatomy and lymphatic vessels, are warranted.
The incidence of second primary neoplasms arising in the skin reconstructive flap (SNAF) is increasing because increase head and neck reconstruction cancer survival. Prognosis, optimal treatment, their clinicopathological-genetic features are under debate difficult to diagnose. We retrospectively reviewed SNAFs based on a single center's experience over 20 years. Medical records specimens 21 patients with SNAF who underwent biopsies between April 2000 2020 at our institute were analyzed....
We investigated whether laryngopharyngeal reflux (LPR) is a risk factor for radiation-induced mucositis.This was retrospective cohort study using our departmental database. The included patients with stage I or II laryngeal and hypopharyngeal cancers treated radiation therapy alone between April 2009 March 2014. Based on endoscopic findings, baseline signs were evaluated the finding score (RFS), severity of mucositis assessed during after therapy.Fifty-eight enrolled. Thirty-one categorized...
Objectives: The indication of transoral robotic surgery for hypopharyngeal cancer is limited because poor accessibility. aim this study was to explore the efficacy a curved laryngopharyngoscope used in combination with next-generation flexible surgical system accessing and resecting hypopharynx. Methods: A comparative evaluation versus standard straight-blade retractors using conducted on 2 cadavers. End points measured included visualization, accessibility, ease dissection Results:...
Abstract Background The purpose of this study was to determine whether a uniform infection screening protocol could be used safely perform head and neck cancer surgery during the coronavirus disease 2019 pandemic clarify how surgical treatment changed compared with pre-pandemic period. Materials methods During unprecedented in Tokyo, we continued providing care, guided by our own protocol. In study, medical records 208 patients malignancy, who underwent at hospital first second wave for each...