A5012618046- COVID-19 Clinical Research Studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Peripheral Neuropathies and Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- HER2/EGFR in Cancer Research
- Long-Term Effects of COVID-19
- Rheumatoid Arthritis Research and Therapies
- Drug-Induced Ocular Toxicity
- Biosimilars and Bioanalytical Methods
- Chronic Lymphocytic Leukemia Research
- Carbon Nanotubes in Composites
- Pleural and Pulmonary Diseases
- Analytical Methods in Pharmaceuticals
- Chemotherapy-induced organ toxicity mitigation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmacogenetics and Drug Metabolism
- Polymer Nanocomposite Synthesis and Irradiation
- Lung Cancer Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Antimicrobial Resistance in Staphylococcus
- COVID-19 epidemiological studies
Uppsala University
2024-2025
Shanghai Chest Hospital
2020-2022
Shanghai Jiao Tong University
2020-2022
Shanghai Public Health Clinical Center
2022
Shuguang Hospital
2019-2020
Shanghai University of Traditional Chinese Medicine
2019-2020
Hydroxychloroquine, a drug commonly used in the treatment of rheumatoid arthritis, has received much negative publicity for adverse events associated with its authorisation emergency use to treat patients COVID-19 pneumonia. We studied safety hydroxychloroquine, alone and combination azithromycin, determine risk routine care arthritis.
ABSTRACT Background Hydroxychloroquine has recently received Emergency Use Authorization by the FDA and is currently prescribed in combination with azithromycin for COVID-19 pneumonia. We studied safety of hydroxychloroquine, alone azithromycin. Methods New user cohort studies were conducted including 16 severe adverse events (SAEs). Rheumatoid arthritis patients aged 18+ initiating hydroxychloroquine compared to those sulfasalazine followed up over 30 days. Self-controlled case series...
Abstract Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use patients. Here, we describe characteristics adults COVID-19 compare them influenza We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) patients, summarising between 4811 11,643 unique aggregate characteristics. patients have been majority male in US Spain, predominantly female...
Abstract Background In this study we phenotyped individuals hospitalised with coronavirus disease 2019 (COVID-19) in depth, summarising entire medical histories, including medications, as captured routinely collected data drawn from databases across three continents. We then compared COVID-19 to those previously influenza. Methods report demographics, recorded conditions and medication use of patients the US (Columbia University Irving Medical Center [CUIMC], Premier Healthcare Database...
Concern has been raised in the rheumatology community regarding recent regulatory warnings that HCQ used coronavirus disease 2019 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation or psychosis associated with as for RA.
ABSTRACT Predicting human lung exposure with reasonable certainty of orally inhaled drugs based on preclinical studies remains a challenge for drug development. We have developed comprehensive physiologically pharmacokinetic (PBPK) framework tailored the pulmonary (PK) behavior in both humans and rats, aiming to bridge translational gap. In this study, we present mechanistic PBPK model rats that integrates disposition processes, including deposition, dissolution, mucociliary clearance, mass...
Background: Numerous vancomycin population pharmacokinetic models in neonates have been published; however, their predictive performances remain unknown. This study aims to evaluate external predictability and explore the factors that might affect model performance. Methods: Published were identified from literature evaluated using datasets two clinical centers, including 171 with a total of 319 measurements levels. Predictive performance was assessed by prediction- simulation-based...
The pharmacokinetics of vancomycin exhibit significant inter-individual variability, particularly among elderly patients. This study aims to develop a predictive model that integrates machine learning with population (popPK) facilitate personalized medication management for this demographic. A retrospective analysis incorporating 33 features, including popPK parameters such as clearance and volume distribution. combination multiple algorithms Shapley Additive Explanations was utilized...
Preclinical studies have shown that anti-cytokine therapies could alter drug dispositions through affecting cytochrome P450 synthesis; however, evidence and case reports evaluating clinical relevance of this interaction are scarce. This is the first reported between cyclosporine etanercept in a 42-year-old male patient with ankylosing spondylitis immunoglobulin A nephropathy whom cytokine levels were monitored both before after initiation. The initiation led to at least 2.5-folds increase...
Background Lamivudine is a first-line medication used for human immunodeficiency virus (HIV) treatment. To date, the population pharmacokinetics of lamivudine in Chinese HIV-infected adults have not been assessed. This study aimed to develop pharmacokinetic model oral and determine optimal dosage regimens.Research design methods A total 1113 samples, from 828 patients treated with 300 mg every 24 hours, were pooled two open-label, prospective clinical trials. analysis was performed using...
Background: Predictive models are necessary to target high-risk populations and provide precision interventions for patients with lung neoplasm who suffer from surgical site infections (SSI). Patients Methods: This case control study included underwent minimally invasive surgeries (MIS). Logistic regression was used generate the prediction model of SSI, a nomogram created. A receiver operator characteristic (ROC) curve examine predictive value model. Results: total 151 SSI were included, 604...
Objective: By assessing the normal dimensions and relationship between aortic root leaflets in Chinese population, objective of this three-dimensional computed tomography (3DCT)-based study was to establish a matching reference for valve (AV) repair. Method: Electrocardiogram-gated multi-detector CT performed on 168 participants with valve. Measurements annuli were obtained. The correlations ratios specific leaflet measurements analyzed. references suggested based geometric height (gH) using...
<title>Abstract</title> Background The pharmacokinetics of vancomycin exhibit significant interindividual variability, particularly among elderly patients. This study aims to develop a predictive model that integrates machine learning with population (popPK) facilitate personalized medication management for this demographic. Methods A retrospective analysis incorporating 33 variables, including popPK parameters such as clearance and volume distribution. combination multiple algorithms...
Aims To establish a simple method to identify chemotherapy-induced liver injury among oncological patients. evaluate current clinical approach elevated laboratory test results. Methods A total of 289 patients admitted oncology department who had systemic chemotherapy episodes for cancer treatment from 1 January 2017 31 December were identified. With aid healthcare information system, Hy's law was applied results potential hepatocellular drug-induced cases. Medical record review carried out...
ABSTRACT Objectives Concern has been raised in the rheumatological community regarding recent regulatory warnings that hydroxychloroquine used COVID-19 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation, or psychosis associated with as for rheumatoid arthritis (RA). Methods New user cohort using claims and electronic medical records from 10 sources 3 countries (Germany, UK US). RA patients aged 18+ initiating were...
Abstract Objective Pyrotinib, a novel oral irreversible dual pan-ErbB tyrosine kinase inhibitor (TKI), has been approved in China for the treatment of HER2-positive advanced or metastatic breast cancer. This study aimed to conduct population pharmacokinetics (PK) analysis pyrotinib and evaluate impact certain cancer patient characteristics on pyrotinib’s PK. Method A total 1152 samples, provided by 59 adult female patients from two phase I clinical trials, were analyzed nonlinear...
Abstract Background Concurrent use of dronedarone and oral anti-coagulants are common since both classes medications essential to atrial fibrillation management. Dronedarone is a moderate inhibitor CYP3A4 P-glycoprotein (P-gp). To date, no drug-drug interaction (DDI) studies between apixaban or rivaroxaban were reported. The current study aims the impact co-administration on exposure with physiologically based pharmacokinetic (PBPK) modeling. Method Modeling simulation conducted Simcyp...
Abstract Background Concurrent use of dronedarone and oral anti-coagulants are common since both classes medications essential to atrial fibrillation (AF) management. Dronedarone is a moderate inhibitor cytochrome P450 3A4 (CYP3A4) P-glycoprotein (P-gp). All direct anticoagulants (DOACs) P-gp substrates, apixaban rivaroxaban in addition metabolized by CYP3A4. The current study aims investigate the impact co-administration on exposure as well bleeding risk or with physiologically based...
Background: The concurrent administration of dronedarone and oral anti-coagulants is common because both are used in managing atrial fibrillation (AF). Dronedarone a moderate inhibitor the cytochrome P4503A4 (CYP3A4) enzyme P-glycoprotein (P-gp). All direct P-gp substrates, including apixaban rivaroxaban, which also metabolized by CYP3A4. This study aimed to investigate impact exposure bleeding risk or rivaroxaban when co-administered with using physiologically-based pharmacokinetic/...